期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 31, 期 5, 页码 892-899出版社
ELSEVIER
DOI: 10.1016/j.msec.2011.02.006
关键词
Micropatterning; Nanotopography; Cell culture; Neural network; Titanium oxide
资金
- European School of Molecular Medicine
Rapid prototyping of titania substrates with micro and nanofeatures is obtained by combining nanosphere lithography with supersonic cluster beam deposition on protein-functionalized glass supports. The proliferation and differentiation of PC12 cells were studied on these substrates. The facile control and modification of the substrate structure at the micro- and nanoscale allowed us to characterize the role of functional and structural features on neuritogenesis and to control this phenomenon by identifying the optimal topography. (C) 2011 Elsevier B.V. All rights reserved.
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