Review
Veterinary Sciences
Felix Bajon, Vincent Gauthier
Summary: Refractory hypoxemia is a challenging condition in patients with acute respiratory distress syndrome treated with mechanical ventilation. Various therapies, including the open lung approach and alternative modalities, have been suggested but their benefits and controversies need further investigation. Personalized approaches and new assessment tools, such as electrical impedance tomography and lung ultrasound, may improve management for patients with severe respiratory failure.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Critical Care Medicine
Susumu Nakahashi, Hiroshi Imai, Nobutake Shimojo, Yasuhiro Magata, Takahiro Einama, Mineji Hayakawa, Takeshi Wada, Yuji Morimoto, Satoshi Gando
Summary: This study assessed the role of prone position in the development of VILI-associated lung inflammation. Using an experimental rabbit lung injury model, it was found that the prone position reduced lung inflammation and slowed down the progression of VILI through the homogenization of lung tissue and mechanical forces.
Article
Physiology
Harry Ramcharran, Jason H. T. Bates, Joshua Satalin, Sarah Blair, Penny L. Andrews, Donald P. Gaver, Louis A. Gatto, Guirong Wang, Auyon J. Ghosh, Benjamin Robedee, James Vossler, Nader M. Habashi, Nirav Daphtary, Michaela Kollisch-Singule, Gary F. Nieman
Summary: Ventilator-induced lung injury is a significant risk for patients with ARDS. Avoiding cyclic recruitment and derecruitment may be more important than overdistension in managing ARDS patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Gary Nieman, Michaela Kollisch-Singule, Harry Ramcharran, Joshua Satalin, Sarah Blair, Louis A. Gatto, Penny Andrews, Auyon Ghosh, David W. Kaczka, Donald Gaver, Jason Bates, Nader M. Habashi
Summary: Time-controlled adaptive ventilation (TCAV) is a novel ventilator approach that considers the temporal aspects of dynamic lung mechanics. It aims to reduce the risk of ventilator-induced lung injury (VILI) by adjusting the duration of expiration and inspiration, leading to improved survival rate of patients.
Article
Physiology
Gabriel C. Motta-Ribeiro, Tilo Winkler, Eduardo L. V. Costa, Nicolas de Prost, Mauro R. Tucci, Marcos F. Vidal Melo
Summary: Lung perfusion redistribution is associated with increased inflammation, nondependent capillary obliteration, and lung derecruitment susceptibility depending on endotoxemia level and ventilation strategy during pre-ARDS protective ventilation in animals.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vazquez, Laia Fernandez-Barat, Montserrat Rigol, Ricard Mellado-Artigas, Gerard Frigola, Marta Camprubi-Rimblas, Pau Ferrer, Daniel Martinez, Antonio Artigas, Carlos Ferrando, Miquel Ferrer, Antoni Torres
Summary: This study successfully established an accurate animal model of ARDS induced by pulmonary sepsis. The model was created in pigs by inducing ARDS through pneumonia, the most common risk factor in humans, and analyzed the additional effect of ventilator-induced lung injury.
Article
Medicine, General & Internal
Mascha O. Fiedler, Emilis Simeliunas, B. Luise Deutsch, Dovile Diktanaite, Alexander Harms, Maik Brune, Maximilian Dietrich, Florian Uhle, Markus A. Weigand, Armin Kalenka
Summary: This study examined the effects of elevated intra-abdominal pressure on lung mechanics in acute respiratory distress syndrome (ARDS) and the impact of different positive end-expiratory pressure (PEEP) levels. The results showed that lung injury worsened in the group with a PEEP of 5 cmH(2)O, but not in the groups with a PEEP of 10 and 15 cmH(2)O. Although Delta P and Delta P-L were significantly lower in group C, there were no significant differences in histological lung injury score between groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Veronica Guillo-Moreno, Alberto Gutierrez-Martinez, Clara Serrano-Zueras, Martin Santos-Gonzalez, Antonio Romero-Berrocal, Javier Garcia-Fernandez
Summary: This study aimed to evaluate the safety and efficacy of two protocols for automatic lung recruitment maneuvers (LRMs) using stepwise increases in PEEP in a neonatal ARDS model. The study found that both protocols were effective in improving oxygenation and respiratory mechanics, and that the duration of the maximum opening pressure step was a determining factor for hemodynamic alterations.
Article
Critical Care Medicine
Tommaso Fossali, Bertrand Pavlovsky, Davide Ottolina, Riccardo Colombo, Maria Cristina Basile, Antonio Castelli, Roberto Rech, Beatrice Borghi, Andrea Ianniello, Nicola Flor, Elena Spinelli, Emanuele Catena, Tommaso Mauri
Summary: This study assessed the physiological effects of prone positioning in COVID-19 patients. The results showed that prone positioning can increase lung recruitment, reduce atelectrauma, and improve ventilation-perfusion matching, which may be associated with more protective ventilation.
CRITICAL CARE MEDICINE
(2022)
Article
Physiology
Gary F. Nieman, Jacob Herrmann, Joshua Satalin, Michaela Kollisch-Singule, Penny L. Andrews, Nader M. Habashi, David G. Tingay, Donald P. Gaver III, Jason H. T. Bates, David W. Kaczka
Summary: Patients with acute respiratory distress syndrome (ARDS) have limited treatment options, and mechanical ventilation itself can cause lung injury. Therefore, improving ventilation management in ARDS patients is crucial. The immediate goal of mechanical ventilation in ARDS is to prevent lung collapse and reopening, while the long-term goal is to reopen collapsed and edematous lung regions and reduce high mechanical stress regions. The ventilation pattern of newborns with short expirations can be used as a reference to reduce end-expiratory derecruitment.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Yukie Ito, Matias G. Herrera, Justin C. Hotz, Miyako Kyogoku, Christopher J. L. Newth, Anoopindar K. Bhalla, Muneyuki Takeuchi, Robinder G. Khemani
Summary: The study found that airway pressure measured during occlusion maneuvers can be used to estimate respiratory effort in children, and expiratory occlusion pressure has the strongest correlation with esophageal pressure change.
Article
Critical Care Medicine
Christoph Boesing, Peter T. Graf, Fabian Schmitt, Manfred Thiel, Paolo Pelosi, Patricia R. M. Rocco, Thomas Luecke, Joerg Krebs
Summary: The study demonstrates that prone positioning combined with appropriate PEEP levels can increase transpulmonary pressures, improve oxygenation, and stabilize hemodynamics in patients with moderate to severe ARDS. Using a lower PEEP strategy (PEEPARDSNetwork) in conjunction with prone positioning may be an effective lung protective ventilation strategy for these patients.
Article
Physiology
Mattia Busana, Carmelo Zinnato, Federica Romitti, Michela Palumbo, Simone Gattarello, Aurelio Sonzogni, Ann-Kathrin Gersmann, Annika Richter, Peter Herrmann, Guenter Hahn, Serena Brusatori, Roberta Maj, Mara Velati, Onnen Moerer, Konrad Meissner, Tom Barnes, Michael Quintel, John J. Marini, Luciano Gattinoni
Summary: Energy dissipation within the respiratory system is recognized as a factor promoting ventilator-induced lung injury (VILI). In this study, we reduced energy dissipation by modulating expiratory flow, but most of the reduction occurred across the endotracheal tube rather than in the respiratory system. Therefore, in healthy lungs, the advantages of reducing energy dissipation do not decrease the risk of VILI, but these advantages may be more significant in diseased lungs under injurious ventilation.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Respiratory System
Vlasios Karageorgos, Athanasia Proklou, Katerina Vaporidi
Summary: In order to adhere to the Hippocratic Oath, efforts must be made to minimize the adverse effects of mechanical ventilation. Recent research has increased our understanding of ventilator-induced lung injury (VILI) and ventilator-induced diaphragm dysfunction (VIDD). Focus is now on monitoring lung stress and inhomogeneity and setting appropriate ventilator targets. Early assisted ventilation also presents new challenges, such as adjusting inspiratory effort and synchronizing patient-ventilator interaction.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Veterinary Sciences
Caterina Di Bella, Caterina Vicenti, Joaquin Araos, Luca Lacitignola, Laura Fracassi, Marzia Stabile, Salvatore Grasso, Alberto Crovace, Francesco Staffieri
Summary: This study compared the effects of a sustained inflation alveolar recruiting maneuver (ARM) and a stepwise ARM in dogs undergoing laparoscopic surgery. The results showed that the group with sustained inflation ARM had higher static compliance and PaO2/FiO(2) values.
FRONTIERS IN VETERINARY SCIENCE
(2022)