期刊
RESEARCH IN VETERINARY SCIENCE
卷 99, 期 -, 页码 87-95出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2015.02.008
关键词
Interferon; Feline; FIV; Immunomodulator; Cytokine
This study assesses viremia, provirus and blood cytokine profile in naturally FIV-infected cats treated with two distinct protocols of interferon omega (rFeIFN-omega). Samples from FIV-cats previously submitted to two single-arm studies were used: 7/18 received the licensed/subcutaneous protocol (SC) while 11/18 were treated orally (PO). Viremia, provirus and blood mRNA expression of interleukin (IL)-1, IL-4, IL-6, IL-10, IL-12p40, Interferon-gamma and Tumor Necrosis Factor-alpha were monitored by Real-Time qPCR. Concurrent plasma levels of IL-6, IL-12p40 and IL-4 were assessed by ELISA. IL-6 plasma levels decreased in the SC group (p = 0.031). IL-6 mRNA expression (p = 0.037) decreased in the PO group, albeit not sufficiently to change concurrent plasma levels. Neither viremia nor other measured cytokines changed with therapy. Proviral load increased in the SC group (p = 0.031), which can be justified by a clinically irrelevant increase of lymphocyte count. Independently of the protocol, rFeIFN-omega seems to act on innate immunity by reducing proinflammatory stimulus. (C) 2015 Elsevier Ltd. All rights reserved.
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