期刊
RESEARCH IN VETERINARY SCIENCE
卷 102, 期 -, 页码 242-246出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2015.07.018
关键词
Antibacterial agent; Anti-inflammatory; Bovine mastitis; Rhodomyrtus tomentosa; Staphylococcus aureus
资金
- Thailand Research Fund [PHD 56I0006]
- Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission, Ministry of Education
- TRF Senior Research Scholar [RTA5880005]
Antibiotic residues in dairy products as well as emergence of antimicrobial resistance in foodbome pathogens have been recognized as global public health concerns. The present work was aimed to study a potent antibacterial extract from natural product as an alternative treatment for staphylococcal bovine mastitis. Staphylococcal isolates (n = 44) were isolated from milk samples freshly squeezed from individual cows. All staphylococcal isolates were resistant to ampicillin, ciprofloxacin, erythromycin, gentamicin, penicillin, except vancomycin. Rhodomyrtus tomentosa leaf ethanolic extract was accessed for its antibacterial activity and anti-inflammatory potential. The extract exhibited profound antibacterial activity against all of staphylococcal isolates with MIC and MBC values ranged from 16-64 mu g/ml and 64->128 mu g/ml, respectively. Moreover, the extract also exerted anti-protein denaturation and human red blood cell membrane stabilizing activity. The results support the use of R. tomentosa extract that could be applied to cure bovine mastitis and to reduce inflammatory injury caused by the bacterial infections. (C) 2015 Elsevier Ltd. All rights reserved.
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