Article
Biochemistry & Molecular Biology
Fanny Jumeau, Nathalie Rives, Pauline Lechevallier, Coline Boniou, Maria Letailleur, Audrey Real-Lhommet, Aurelie Feraille
Summary: Sperm chromatin condensation is found to have an impact on the kinetics of early embryo development. However, it does not affect live birth rates or the occurrence of miscarriages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shikai Wang, Weihong Tan, Yueyue Huang, Xianbao Mao, Zhengda Li, Xiaohui Zhang, Pingpin Wei, Lintao Xue
Summary: This study demonstrates that SDF >= 15% reduces the fertilization rate of ICSI cycles and affects certain morphokinetic parameters. A higher SDF level can also induce a higher rate of chaotic cleavage, with subsequent decreases in the blastocyst formation rate and blastocyst quality.
Article
Endocrinology & Metabolism
Hongyi Yang, Yan Liu, Wenbin Niu, Zilan Yang, Yang Wang, Haixia Jin, Gang Li
Summary: This study aimed to evaluate the influence of abnormal semen parameters on embryo aneuploidy using a single nucleotide polymorphism microarray (SNP array). The results showed that abnormal semen parameters may affect embryo quality and increase the rate of aneuploidy in blastocyst chromosomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Yolanda Cabello, Pedro Belchin, Mercedes Gonzalez-Martinez, Carmen Lopez-Fernandez, Stephen Johnston, Jaime Gosalvez
Summary: The study investigated the effect of a novel non-centrifugation method (Io-Lix) on sperm parameters and ICSI reproductive outcomes. The results showed that Io-Lix sperm selection improved sperm parameters and reduced DNA fragmentation, leading to an increase in pregnancy rate and reduction in miscarriage in autologous ICSI. However, no significant difference was observed in the donor oocyte ICSI program.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Developmental Biology
H. Newman, S. Catt, B. Vining, B. Vollenhoven, F. Horta
Summary: This systematic review explores the maternal mechanisms involved in responding and repairing sperm DNA damage during early embryonic development. The evidence suggests that the early embryo has the ability to repair DNA damage within sperm through maternally driven mechanisms, though this capacity may decline with age. Understanding these mechanisms could have important clinical implications for improving fertility outcomes and developing targeted therapies.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Manar Hozyen, Eman Hasanen, Khaled Elqusi, Salma ElTanbouly, Samar Gamal, Abdul Ghafar Hussin, Hanaa AlKhader, Hosam Zaki
Summary: In patients with abnormal SDF undergoing ICSI treatment, the PICSI group showed the highest pregnancy rate while the DGC group had the lowest. The PICSI group also had a significantly higher implantation rate than the other groups, with the MACS and DGC groups performing better in terms of high-quality blastocyst rates.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Dana B. McQueen, Jenna Mazur, Dana Kimelman, Rafael Confino, Jared C. Robins, Lia A. Bernardi, Chen Yeh, John Zhang, Mary Ellen Pavone
Summary: The study found no significant differences in morphokinetic parameters between embryos resulting in euploid pregnancy loss and those resulting in live birth, indicating that euploid pregnancy loss may be multifactorial.
FERTILITY AND STERILITY
(2021)
Article
Andrology
Daniela Paes Almeida Ferreira Braga, Amanda Setti, Christina Morishima, Rodrigo R. Provenza, Assumpto Iaconelli Jr, Edson Borges Jr
Summary: This study aimed to investigate the relationship between sperm DNA fragmentation and intracytoplasmic sperm injection (ICSI) outcomes, and whether this relationship is influenced by the presence of oocyte dimorphisms. The results showed that ICSI cycles with lower sperm DNA fragmentation had higher rates of fertilization, high-quality embryos, implantation, and pregnancy. The presence of oocyte dimorphisms significantly affected the outcomes. The lowest rates of fertilization and high-quality embryos were observed when high sperm DNA fragmentation was associated with certain oocyte defects, such as dark cytoplasm, vacuoles, resistant membrane, and non-resistant membrane.
Article
Endocrinology & Metabolism
Chunhui Zhu, Fang Chen, Shengmin Zhang, Hong She, Yun Ju, Xidong Wen, Chunxia Yang, Yan Sun, Naijun Dong, Tongmin Xue, Kaifeng Liu, Feng Li, Hengmi Cui
Summary: The study results indicate that an increase in sperm DFI significantly reduces the success rate of fresh embryo transfer cycles, as well as the biochemical pregnancy rate and clinical pregnancy rate of frozen embryo transfer cycles.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biology
Jordi Ribas-Maynou, Marc Yeste, Nerea Becerra-Tomas, Kenneth Aston, Emma R. James, Albert Salas-Huetos
Summary: A systematic review and meta-analysis of studies on IVF and ICSI treatments revealed a significant negative impact of sperm DNA damage on implantation and pregnancy rates. Routine sperm DNA testing is justified to improve IVF outcomes and assist in treatment selection for couples. Further studies are needed to draw more precise conclusions, especially in the context of ICSI treatments.
BIOLOGICAL REVIEWS
(2021)
Article
Medicine, General & Internal
Rossella Cannarella, Rosita A. Condorelli, Aldo E. Calogero, Vincenzo Bagnara, Antonio Aversa, Emanuela A. Greco, Antonio Brunetti, Sandro La Vignera
Summary: The study evaluated the effects of oral Se supplementation on conventional sperm parameters and DNA fragmentation in patients with AT of reproductive age with normal thyroid function. Results showed that after Se supplementation, patients had improved sperm parameters and reduced DNA fragmentation, suggesting that Se supplementation may be a potential therapeutic option for male infertility. Further studies are needed to confirm these findings and clarify the potential thyroid hormone dependency.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yuqing Jiang, Zhaoyang Shen, Jianmin Xu, Jing Zhu, Huan Wang, Wenhui Chen, Yingpu Sun, Qingling Yang
Summary: High sperm DNA fragmentation index (DFI) in overweight/obese women during ICSI cycles leads to decreased fertilization, cleavage, and high-quality embryo rates. The diminished capacity of oocytes to repair sperm DNA damage may be the cause of the decreased early developmental potential in embryos from overweight/obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elena Berg, Petr Houska, Nils Nesheim, Hans-Christian Schuppe, Adrian Pilatz, Monika Fijak, Marc Manthey, Klaus Steger, Florian Wagenlehner, Undraga Schagdarsurengin
Summary: This study compares CP/CPPS patients and healthy volunteers, finding increased sperm DNA fragmentation and abnormal protamine levels in CP/CPPS patients, which have a negative impact on fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Shiao Chuan Chua, Steven John Yovich, Peter Michael Hinchliffe, John Lui Yovich
Summary: Sperm DNA fragmentation (SDF) levels were measured in IVF workup using Halosperm test. 2567 semen samples were analyzed and correlated with semen analysis profiles and clinical parameters. The results showed significant correlation with male age, abstinence period, semen volume, sperm morphology, motility, and pH. Elevated DFI is associated with poor sperm quality and should be investigated in IVF clinical trials.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Christophe Depuydt, Eugene Bosmans, Jef Jonckheere, Francesca Donders, Willem Ombelet, Astrid Coppens, Gilbert Donders
Summary: This longitudinal observational cohort study found that SARS-CoV-2 infection has differential effects on sperm quality and fertility, including parameters such as motility, morphology, DNA damage, and anti-sperm antibodies. These effects may vary among individuals. However, most sperm parameters return to normal after infection.
Article
Medicine, General & Internal
Artur Wdowiak, Marta Makara-Studzinska, Dorota Raczkiewicz, Paula Janczyk, Aneta Slabuszewska-Jozwiak, Anita Wdowiak-Filip, Noemi Studzinska
Summary: The study found that women who were overweight before pregnancy were more likely to experience depressive symptoms during pregnancy, increasing the risk of preterm delivery and negatively impacting the well-being of the newborn. Depressive symptoms among pregnant, overweight, and obese women intensified during the COVID-19 pandemic.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Mariusz Gujski, Dorota Raczkiewicz, Ewa Humeniuk, Beata Sarecka-Hujar, Artur Wdowiak, Iwona Bojar
Summary: The study found a significant link between the severity of depressive symptoms and healthy behaviors in postmenopausal women, with this link being more evident in rural women compared to urban women. Postmenopausal women living in rural areas experienced menopause earlier, were more often widowed, more often obese, and had lower levels of education compared to those in urban areas.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Artur Wdowiak, Agnieszka Anusiewicz, Grzegorz Bakalczuk, Dorota Raczkiewicz, Paula Janczyk, Marta Makara-Studzinska
Summary: This study evaluated the quality of life of women undergoing infertility treatment and found that reproductive issues, treatment methods, age, place of residence, and education level can impact quality of life. Prolonged treatment duration is associated with a decrease in quality of life.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Artur Wdowiak, Mariusz Gujski, Iwona Bojar, Dorota Raczkiewicz, Joanna Bartosinska, Anita Wdowiak-Filip, Rafal Filip
Summary: Recent evidence suggests that inflammation may negatively impact male fertility. This study found that male patients with ulcerative colitis (UC) had significantly lower sperm quality parameters compared to healthy individuals, possibly due to intensified oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Grazyna Iwanowicz-Palus, Marta Zarajczyk, Agnieszka Bien, Magdalena Korzynska-Pietas, Justyna Krysa, Mansur Rahnama-Hezavah, Artur Wdowiak
Summary: The aim of this study was to assess the impact of socio-demographic variables on social support and self-efficacy levels, and investigate the relationship between social support and self-efficacy in pregnant women with gestational diabetes. The results showed a relationship between perceived support and self-efficacy, with an increase in support leading to higher self-efficacy levels.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Krzysztof Lukaszuk, Grzegorz Jakiel, Izabela Woclawek Potocka, Jolanta Kiewisz, Jolanta Olszewska, Wlodzimierz Sieg, Amira Podolak, Ewa Pastuszek, Artur Wdowiak
Summary: ICSI is a commonly used treatment for oocyte fertilization, and the quality of sperm selection depends on accurate visualization of morphology. We emphasize the importance of optical system's resolution in observing sperm and provide specific microscope system setup recommendations. Furthermore, a lack of standardization in microscopy techniques for both ICSI and IMSI may contribute to mixed research results.
Review
Biochemistry & Molecular Biology
Aneta Slabuszewska-Jozwiak, Aron Lukaszuk, Marta Janicka-Kosnik, Artur Wdowiak, Grzegorz Jakiel
Summary: Obesity is strongly associated with the development of endometrial cancer, and adipokines such as adiponectin and leptin may play a role in this process. Understanding the signaling pathway of these cytokines in endometrial cancerogenesis could potentially lead to targeted therapies and fertility-sparing treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Marta Makara-Studzinska, Agnieszka Limanin, Agnieszka Anusiewicz, Paula Janczyk, Dorota Raczkiewicz, Anita Wdowiak-Filip, Michal Filip, Iwona Bojar, Krzysztof Lukaszuk, Artur Wdowiak
Summary: This study aimed to assess the quality of life of men treated for infertility in Poland, revealing that factors such as treatment methods, type of reproductive problems, and living environment can influence the quality of life of affected men.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Grzegorz Niemczyk, Piotr Zapala, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wrobel
Summary: This paper aimed to investigate whether the selective cannabinoid CB1 receptor agonist ACEA could reverse the effects of corticosterone (CORT) on depressive and overactive bladder potential. Through experiments on 48 female rats, it was found that ACEA could restore CORT-induced bladder dysfunction and depressive behavior, as well as regulate urine and other biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Agnieszka Baranska, Wieslaw Kanadys, Artur Wdowiak, Maria Malm, Agata Blaszczuk, Urszula Religioni, Anita Wdowiak-Filip, Malgorzata Polz-Dacewicz
Summary: This report evaluated the association between in utero exposure to paracetamol and the risk of developing respiratory disorders such as asthma and wheeze after birth. The study included 330,550 women, and the results showed a significant increased risk of asthma and wheezing in children whose mothers were exposed to paracetamol during pregnancy. Therefore, caution should be exercised when using paracetamol during pregnancy, with the lowest effective dose and shortest duration of use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Paulina Iwaniak, Piotr Dobrowolski, Jan Wrobel, Tomasz Kluz, Artur Wdowiak, Iwona Bojar, Klaudia Stangel-Wojcikiewicz, Ewa Poleszak, Artur Jakimiuk, Marcin Misiek, Lukasz Zapala, Andrzej Wrobel
Summary: The study suggests that imperatorin has the potential to alleviate the symptoms of overactive bladder syndrome and improve bladder function and biochemical changes. Its mechanisms of action are diverse and complex, making it a promising candidate for the treatment of OAB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Pawel Dybciak, Dorota Raczkiewicz, Ewa Humeniuk, Tomasz Powrozek, Mariusz Gujski, Teresa Malecka-Massalska, Artur Wdowiak, Iwona Bojar
Summary: This meta-analysis utilized research utilizing the Hospital Anxiety and Depression Scale (HADS) to determine the prevalence, mean level, standardized mean difference, and probability of depression in patients with PCOS. The results indicate an increased risk of depressive symptoms in women with PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Iwona Bojar, Dorota Raczkiewicz, Mariusz Gujski, Ewa Humeniuk, Artur Wdowiak, Alfred Owoc, Jaroslaw Pinkas
Summary: This study found a close relationship between the severity of insomnia and cognitive function during menopausal transition, especially in relation to estrogen receptor a gene polymorphism.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Pawel Dybciak, Ewa Humeniuk, Dorota Raczkiewicz, Jan Krakowiak, Artur Wdowiak, Iwona Bojar
Summary: This study aimed to examine the prevalence and severity of anxiety and depression symptoms, ego-resiliency levels, and stress-coping methods among women with polycystic ovary syndrome (PCOS) compared to healthy women. The results showed that women with PCOS had higher levels of anxiety and depression, as well as poorer ego-resiliency, compared to healthy women. Furthermore, the study identified specific socio-demographic characteristics that were associated with increased anxiety and depression levels in women with PCOS.
MEDICINA-LITHUANIA
(2022)
Article
Reproductive Biology
Patrycja Kurowska, Ewa Mlyczynska, Julia Wajda, Konrad Krol, Karolina Pich, Patrycja Guzman, Aleksandra Greggio, Oliwia Szkraba, Malgorzata Opydo, Joelle Dupont, Agnieszka Rak
Summary: This study investigated the expression of PNX-14 and GPR173 in ovarian tissue and the effects of PNX-14 on granulosa cell function. The results showed that PNX-14 can influence ovarian follicle growth by promoting granulosa cell proliferation, hormone secretion, and cell cycle progression.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Sonia Srivastava, Swarnima Mishra, Gyan Babu, Banalata Mohanty
Summary: This study aimed to investigate the efficacy of PD149163 in preventing/ameliorating LPS-induced inflammation in the female reproductive system of mice. The results showed that PD149163 reduced/prevented the inflammation in the ovary and uterine horn, restored the balance of inflammatory cytokines and oxidative stress, and recovered the levels of reproductive hormones and corticosterone.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Chen Zhang, Hongyan Cheng, Xue Ye, Heng Cui, Yi Li, Honglan Zhu, Xiaohong Chang
Summary: Extracellular matrix protein 1 (ECM1) is significantly upregulated in endometriosis tissues. Blocking ECM1 attenuates cell migration and invasion. ECM1 regulates cell migration, invasion, and cytoskeleton reorganization via the RhoC/ROCK1 signaling pathway.
REPRODUCTIVE BIOLOGY
(2024)
