Article
Agriculture, Dairy & Animal Science
Dongmei Jiang, Chunyang Niu, Qian Sun, Xiaoguang An, Chengweng Ji, Weikang Ling, Liang Li, Hua Zhao, Chunchun Han, Hehe Liu, Jiwei Hu, Bo Kang
Summary: Oxidative stress is the main cause of ovarian dysfunction due to damage to granulosa cells (GCs). Ferritin heavy chain (FHC) may regulate ovarian function by mediating GCs apoptosis. However, the specific regulatory function of FHC in follicular GCs is still unclear.
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Chang Shan, Jiang Yue, Wei Liu
Summary: Bones are now seen as an important endocrine organ, with osteocalcin playing a crucial role in influencing insulin secretion, glucose and lipid metabolism, testosterone biosynthesis, and male fertility. However, the detailed functional mechanisms of osteocalcin on the hypothalamic-pituitary-gonadal axis or the pancreas-bone-gonadal axis are not fully understood.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ozlem Atli Eklioglu, Sinem Ilgin
Summary: The HPG axis plays a crucial role in male reproductive function, with neurotransmitters regulating the release of GnRH by affecting GnRH-releasing neurons. Patients with epilepsy often experience decreased fertility potential and lower sperm quality, which may be related to the impact of antiepileptic drugs on the HPG axis. Antiepileptic drugs can act as endocrine-disrupting chemicals, affecting fertility and exacerbating adverse effects on sperm quality in individuals with epilepsy. Investigating the reproductive effects of antiepileptic drugs and understanding the role of the HPG axis in potential reproductive pathologies is essential.
Article
Fisheries
Jiamin Pi, Huan Zhong, Yi Zhou, Tao Dai, Weiling Qin, Hui Liu, Yi Zhang, Yuling Zhou
Summary: This study aimed to investigate the regulatory role of ghrelin on ovarian development in grass carp and its mechanism on key hormonal receptors. The results showed high expression of ghrelin and ghrelin O-acyltransferase in the ovary, and stimulation of folliclestimulating hormone receptor expression by ghrelin treatment. Furthermore, acyl-ghrelin inhibited estrogen receptor-alpha expression, while octanoic acid treatment inhibited ER beta 1 and ER beta 2 expression in the ovary.
AQUACULTURE REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Hwan-Deuk Kim, Young-Jong Kim, Min Jang, Seul-Gi Bae, Sung-Ho Yun, Mi-Ree Lee, Yong-Ryul Seo, Jae-Keun Cho, Seung-Joon Kim, Won-Jae Lee
Summary: This study investigated the effect of heat stress on reproductive performance in domestic sows and found that heat stress in summer reduced the expression of hypothalamic kisspeptin, resulting in decreased levels of reproductive hormones and fewer large ovarian follicles, leading to summer infertility in sows.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Liu, Wenzhi Lv, Weiyin Vivian Liu, Tian Tian, Yuanyuan Qin, Yakun Li, Qin Liu, Jianjian Cai, Sikang Gao, Guojun Ding, Yunyun Zhao, Yiran Zhou, Yan Xie, Wenzhen Zhu
Summary: A noninvasive method using MRI radiomics model was explored to evaluate HPG axis activation in children, providing valuable information in assessing the onset of physiological or pathological puberty. The radiomics model based on CUBE T1WI showed good performance in assessing HPG axis activation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Agriculture, Dairy & Animal Science
Chong Li, Yanfang Cao, Yangguang Ren, Yudian Zhao, Xing Wu, Sujin Si, Jing Li, Qi Li, Na Zhang, Donghua Li, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Ruirui Jiang, Yadong Tian
Summary: This study investigated the correlation between adiponectin levels and reproductive hormones in laying hens. The results showed a significant correlation between adiponectin and reproductive hormones in the hypothalamic-pituitary-ovarian (HPO) axis. AdipoRon, an activator of adiponectin receptors, was found to promote the secretion of reproductive hormones and enhance the expression of genes related to follicle and testicular development.
Article
Endocrinology & Metabolism
Angela Cristina Nicola, Larissa Brazoloto Ferreira, Milene Mantovani Mata, Tatiane Vilhena-Franco, Cristiane Mota Leite, Andressa Busetti Martins, Jose Antunes-Rodrigues, Maristela Oliveira Poletini, Rita Cassia Menegati Dornelles
Summary: During early embryonic development, there are complex interactions and changes in gene expression to adapt to the needs of different stages of embryonic development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agronomy
Qiang Bao, Di Liu, Yujiao Guo, Wang Gu, Zhengfeng Cao, Yu Zhang, Yang Zhang, Qi Xu, Guohong Chen
Summary: This study investigates the regulation of circadian egg-laying in Yangzhou geese, finding that egg production exhibits rhythmic patterns related to light-driven melatonin secretion. The laying rates show diurnal fluctuations, with a peak during the early morning hours. Clock genes and melatonin secretion also display circadian rhythmicity, with melatonin receptor expression being higher during the night period.
Article
Medicine, Research & Experimental
Yin Zhang, Peifang Cong, Changci Tong, Hongxu Jin, Yunen Liu, Mingxiao Hou
Summary: The study demonstrated that melatonin pretreatment alleviated blast-induced behavioral abnormalities in mice and maintained HPG axis hormone homeostasis in rats. Melatonin upregulated Nrf2/HO-1 expression, inhibited NF-kappa B expression, and reversed blast-induced oxidative stress, inflammation, and apoptosis. This suggests that melatonin could be a potential treatment for blast-induced HPG axis hormonal and behavioral abnormalities.
Article
Physiology
Yi Zhang, Tianyu Guan, Long Wang, Xintong Ma, Chuankun Zhu, Hui Wang, Jiale Li
Summary: In this study, the effects of MET on the endocrine system of rice field eels were investigated. It was found that MET has estrogen-like effects and strongly interferes with the expression of HPG axis genes, suppressing the expression of female pathway genes and promoting the expression of male pathway genes.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Toxicology
Kayke L. Barbosa, Raquel S. Dettogni, Charles S. da Costa, Eduardo L. Gastal, Lori T. Raetzman, Jodi A. Flaws, Jones B. Graceli
Summary: The HPG axis is crucial for reproductive function control, and exposure to TBT can lead to toxicity in the female reproductive axis components, affecting hypothalamic GnRH expression, folliculogenesis, steroidogenesis, and ovulation. Further research is needed to understand the mechanisms underlying the impairment caused by TBT in the HPG axis.
TOXICOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Yehan Bian, Heidi Hahn, Anja Uhmann
Summary: Hedgehog signaling plays essential roles in embryonic development, adult homeostasis, and tumorigenesis. Despite its close connection with pituitary embryonic development, the engagement of Hedgehog signaling in the pituitary gland has been underestimated. Dysfunction of this signaling pathway during pituitary development leads to gland malformation. Recent research also suggests a regulatory role of Hedgehog signaling in the adult pituitary, affecting homeostasis, hormone production, and possibly formation of neoplasms. Targeting this pathway with therapeutic strategies shows promise in treating pituitary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Patrycja Kurowska, Ewa Mlyczynska, Julia Wajda, Konrad Krol, Karolina Pich, Patrycja Guzman, Aleksandra Greggio, Oliwia Szkraba, Malgorzata Opydo, Joelle Dupont, Agnieszka Rak
Summary: This study investigated the expression of PNX-14 and GPR173 in ovarian tissue and the effects of PNX-14 on granulosa cell function. The results showed that PNX-14 can influence ovarian follicle growth by promoting granulosa cell proliferation, hormone secretion, and cell cycle progression.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Sonia Srivastava, Swarnima Mishra, Gyan Babu, Banalata Mohanty
Summary: This study aimed to investigate the efficacy of PD149163 in preventing/ameliorating LPS-induced inflammation in the female reproductive system of mice. The results showed that PD149163 reduced/prevented the inflammation in the ovary and uterine horn, restored the balance of inflammatory cytokines and oxidative stress, and recovered the levels of reproductive hormones and corticosterone.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Chen Zhang, Hongyan Cheng, Xue Ye, Heng Cui, Yi Li, Honglan Zhu, Xiaohong Chang
Summary: Extracellular matrix protein 1 (ECM1) is significantly upregulated in endometriosis tissues. Blocking ECM1 attenuates cell migration and invasion. ECM1 regulates cell migration, invasion, and cytoskeleton reorganization via the RhoC/ROCK1 signaling pathway.
REPRODUCTIVE BIOLOGY
(2024)
