期刊
REPRODUCTIVE BIOLOGY
卷 15, 期 4, 页码 257-260出版社
INST ANIMAL REPRODUCTION FOOD RESEARCH
DOI: 10.1016/j.repbio.2015.07.004
关键词
Neuropeptide Y; Ovary; Proliferation; Apoptosis; Transcription factor p53
资金
- Operational Programme Research and Development from the European Regional Development Fund, project ZDRAVIE [26220220176]
- Dean of Scientific Research at King Saud University [164]
The effects of neuropeptide Y (NPY; 0, 10, 100 and 1000 ng/mL) on the expression of PCNA, bax and p53 were examined by immunocytochemistry in porcine luteinized granulos a cells. NPY inhibited proliferation as well as promoted apoptosis and accumulation of p53 in the cells. This is the first report to demonstrate the direct action of NPY on ovarian cell proliferation and apoptosis. The results of the study suggest that the effect is mediated by transcription factor p53. (C) 2015 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Sp. z o.o. All rights reserved.
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