Article
Marine & Freshwater Biology
Mariana de Almeida Torres, Martin R. Jones, Colette vom Berg, Ernani Pinto, Elisabeth M. -L. Janssen
Summary: Cyanobacterial blooms have a global impact on aquatic ecosystems, and their toxins, such as microcystins (MC), are a major concern. However, the ecotoxicological risks, especially non-lethal effects, associated with other co-produced secondary metabolites, remain largely unknown. In this study, we assessed the effects of cyanobacterial extracts from two Brazilian Microcystis strains on the survival, morphological alterations, swimming behavior, and cardiovascular functions of zebrafish. We found that only one strain produced MCs, and we identified other co-produced cyanopeptides using LC-HRMS/MS analysis even in the non-producer strain. Both cyanobacterial extracts caused acute toxicity in zebrafish, with varying severity. Additional decreased locomotor activity and specific adverse effects in zebrafish were observed in response to cyanobacterial metabolites other than MCs. These results highlight the need to further investigate the lethal and sublethal effects of cyanobacterial metabolites, other than MCs, and understand their underlying mechanisms of toxicity. Considering the mixture toxicity of co-produced metabolites is crucial for the ecotoxicological risk assessment of cyanobacterial bloom events, as it allows better prediction of adverse outcomes in fish and other organisms.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
Liwen Qiang, Nan Zhao, Kaizhen Liao, Xichao Sun, Qiang Wang, Hangbiao Jin
Summary: ENPs can resist heavy metal toxicity in plants, but their coexposure still exhibits toxicity to plants. This study aimed to investigate the toxic mechanism of nano TiO2 or TiO2-Cd on rice using transcriptomics and metabolomics. The findings showed that nano TiO2-Cd coexposure significantly decreased the plant height and root dry weight of rice. Nano TiO2 exposure induced regulation of DEGs and metabolites, while nano TiO2-Cd coexposure identified a greater number of DEGs and differential metabolites. The study highlights the importance of being cautious when using ENPs to combat heavy metal phytotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Chi Wu, Lan Zhang, Liangang Mao, Lizhen Zhu, Yanning Zhang, Hongyun Jiang, Yongquan Zheng, Xingang Liu
Summary: This study conducted a comprehensive evaluation on the behavior of prothioconazole and its metabolites in different environmental conditions, finding that the half-life of metabolites in soils was higher than that of prothioconazole itself.
Article
Environmental Sciences
Qing Zhong, Hongxia Li, Min Wang, Fengjian Luo, Xinru Wang, Haifeng Yan, Tao Cang, Li Zhou, Zongmao Chen, Xinzhong Zhang
Summary: This study systematically investigated the potential harm and toxicity of chiral pesticides during the growth, processing, and brewing of tea. It found that the degradation products of indoxacarb and their toxicity varied depending on the tea production process. The results highlight the importance of considering metabolites and enantiomeric differences when assessing the risk of chiral pesticides in tea.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Ana Paula Da Silva, Elizete Rodrigues Morais, Elton Celton Oliveira, Nedia de Castilhos Ghisi
Summary: This meta-analysis study evaluates the toxic effects of 2,4-dichlorophenoxyacetic acid (2,4-D) on various animal species. The results indicate a significant increase in mortality rate for animals exposed to environmental concentrations of 2,4-D, with fish and birds being more susceptible. Larval and adult animals are more sensitive to 2,4-D, and immersion exposure has the greatest impact. Furthermore, commercial formulations have a higher mortality rate compared to analytical standards.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Urmi Das, Md Atikur Rahman, Esrat Jahan Ela, Ki-Won Lee, Ahmad Humayan Kabir
Summary: This study demonstrates that supplementation of sulfur can alleviate cadmium toxicity in alfalfa plants by restoring biomass, chlorophyll synthesis, and protein concentration, as well as enhancing photosynthetic kinetics and membrane stability. The mechanisms involve upregulation of sulfate transporters, glutathione and phytochelatin synthesis, and subcellular sequestration of excess cadmium in roots under sulfur surplus conditions. These findings provide valuable insights for developing cadmium-free forage crops through sulfur application and breeding/transgenic experiments.
Article
Biotechnology & Applied Microbiology
Jiali Wang, Zefei Jia, Wen Pan, Jing Hu
Summary: This research investigated the harmful impacts and underlying mechanisms of Crotonis Fructus (CF), a traditional poisonous laxative. The study found that CF induced hepatic and gastrointestinal damage, disrupted gut microbiota composition, and disturbed metabolites. The results provide a new understanding of toxic traditional medicine.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Yongtian Xing, Han Xing, Yongcheng Ma, Qingwang Liu, Suyan Xu
Summary: Marrubiin, a furanoid compound isolated from Marrubium vulgare, is known for its pharmacological effects and potential hepatotoxicity. In rats and humans, marrubiin undergoes metabolic activation to form a cis-butene-1,4-dial intermediate, which can react with glutathione and N-acetyl-lysine. Enzyme phenotyping studies revealed that CYP2C9, CYP2C19, and CYP3A4 are the primary enzymes responsible for the bioactivation of marrubiin, shedding light on the potential side effects associated with this compound.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Environmental Sciences
Yingjuan Ou, Zhiyong Yan, Guofeng Shi, Ziling Yu, Yixiang Cai, Ruixue Ma
Summary: The present study aimed to investigate the aquatic toxicity and environmental behavior of fipronil at enantiomeric level using two freshwater algae. The results revealed that the R-enantiomer of fipronil had a more significant effect on algal growth inhibition and was more favorable for degradation than the S-enantiomer.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Xinlei Li, Shiyue Chen, Lili Zhao, Xiangpeng Zeng, Yanyan Liu, Chaochuang Li, Qingxiang Yang
Summary: This study explored the effects of copper (Cu) concentrations on the functions of intestinal microbes using a strain of lactic acid bacteria as an indicator. It was found that low Cu concentrations affected the metabolic pathways and activity of lactic acid bacteria, while high Cu concentrations inhibited their growth and primary metabolite production. To protect the health of intestinal microbes, it is recommended to limit the Cu concentration in food to less than 4 mg/L.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Food Science & Technology
Karolina Ropejko, Magdalena Twaruzek
Summary: Mycotoxins are common food contaminants produced by filamentous fungi, with Zearalenone being one of over 400 detected toxins. Zearalenone, mainly produced by Fusarium fungi, has estrogenic effects and can lead to economic losses and pose risks to animals and humans. Further research and monitoring are needed to address the impact of mycotoxins on the food chain.
Article
Environmental Sciences
Marc-Christopher Hildebrand, Alexander Rebl, Julien Alban Nguinkal, Harry Wilhelm Palm, Bjoern Bassmann
Summary: Fingerlings and juveniles of African catfish were reared under experimental conditions and exposed to different concentrations of Fe-DTPA. Various factors such as growth, behavior, immune response, histopathological changes, and genetic biomarkers were evaluated. The results indicate that Fe-DTPA supplementation at the tested concentrations is relatively harmless for the health and welfare of African catfish.
Review
Food Science & Technology
Ranjitha T. K. Gracy, P. S. Sharanyakanth, Mahendran Radhakrishnan
Summary: The issue of pesticide residues above the maximum permissible limit in food is a serious concern, requiring appropriate non-thermal technologies for elimination. These novel technologies show promise in reducing pesticides, but their impact on the nutritional and sensory quality of food products needs further study.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Peng Wang, Qin-Qin Li, Jin Hui, Qian-Qian Xiang, Hui Yan, Li-Qiang Chen
Summary: The study showed that exposure to MPs-20 and MPs-30 resulted in significant accumulation of microplastics in the gut of D. magna, decreased survival and heart rate. Metabolomics analysis revealed that both MPs-20 and MPs-30 induced significant changes in numerous metabolites in D. magna.
Article
Chemistry, Medicinal
Shishir Chourey, Rui Wang, Qiuji Ye, Chintam Nagendra Reddy, Shiyu Sun, Norito Takenaka, William S. Powell, Joshua Rokach
Summary: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant mediated by the OXE receptor. A highly potent indole-based OXE antagonist, S-C025, was converted to four major metabolites by oxidation at the benzylic and N-methyl carbon atoms. Here, we report concise syntheses of these metabolites.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Evelyn Assadian, Hamid Dezhampanah, Enayatollah Seydi, Jalal Pourahmad
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Article
Environmental Sciences
Ahmad Salimi, Mahnia Nikoosiar Jahromi, Jalal Pourahmad
ENVIRONMENTAL TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Maral Ramazani, Razieh Pourahmad Jaktaji, Farshad H. Shirazi, Maria Tavakoli-Ardakani, Ahmad Salimi, Jalal Pourahmad
BMC PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Ahmad Salimi, Farnaz Bahreini, Zhaleh Jamali, Jalal Pourahmad
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2020)
Article
Oncology
Ahmad Salimi, Marjan Aghvami, Mahsa Azami Movahed, Mohammad Hadi Zarei, Peyman Eshghi, Afshin Zarghi, Jalal Pourahmad
CANCER INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Jahanfar Jahanbani, Maryam Ghotbi, Fatemeh Shahsavari, Enayatollah Seydi, Shabnam Rahimi, Jalal Pourahmad
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Ahmad Salimi, Nasrin Alyan, Nasim Akbari, Zhaleh Jamali, Jalal Pourahmad
Summary: This study demonstrates the protective effects of sodium selenite and L-carnitine against valproic acid-induced oxidative stress and mitochondrial dysfunction.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Vahideh Atabaki, Enayatollah Seydi, Tahereh Hosseinabadi, Jalal Pourahmad, Maral Ramezani, Fatemeh Samiei
Summary: In this study, three guaianolide-type sesquiterpene lactones were extracted from Jurinea gabrieliae Bornm and found to have potential inhibitory effects on glioblastoma, without negative effects on normal neurons.
NATURAL PRODUCT RESEARCH
(2022)
Article
Toxicology
Ahmad Salimi, Mina Kazemnezhad, Baharak Mohammadzadeh Asl, Farzaneh Jokar, Zhaleh Jamali, Jalal Pourahmad
Summary: The study found that mephedrone has adverse effects on embryo-fetal development in mice, leading to abortion and impacting the development and mitochondrial function of the placenta and fetus. These results are important in increasing awareness of the potential embryo-fetal toxicity of mephedrone.
Article
Public, Environmental & Occupational Health
Ahmad Salimi, Ali Alavehzadeh, Maral Ramezani, Jalal Pourahmad
Summary: This study aimed to evaluate the cytotoxicity of PVC microplastics on human and fish blood lymphocytes. The results showed that human lymphocytes were more sensitive to PVC microplastic toxicity compared to fish lymphocytes, and this toxicity was associated with factors such as intracellular ROS formation and lysosomal membrane injury.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Mahban Rahimifard, Nafiseh Jalalimanesh, Mahsa A. Movahed, Mahmoudreza Hadjighassem, Razieh Pourahmad Jaktaji, Zeinab Bagheri, Jalal Pourahmad, Afshin Zarghi
Summary: This study evaluated the metal chelation and antiproliferative properties of new derivatives of pyrazino[1,2-a]benzimidazole. The results showed that the 3,4,5-trimethoxy substituted pyrazino[1,2-a]benzimidazole had better electron donor ability, reduced proliferation, and increased apoptosis in human glioblastoma cancer cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Enayatollah Seydi, Marjan Rahemi, Hadi Esmaily, Abdollah Arjmand, Jalal Pourahmad
Summary: Transplanting healthy mitochondria can reduce the cytotoxicity, ROS production, MMP collapse, lysosomal damage, GSSG levels, and caspase-3 activity caused by FAV in RPTCs, while increasing ATP level, GSH content, Bcl-2 content, and GSH/GSSG ratio.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Evelyn Assadian, Zhaleh Jamali, Ahmad Salimi, Jalal Pourahmad
Summary: This study investigated the protective role of antioxidant and mitochondrial/lysosomal protective agents against titanium dioxide nanoparticles-induced toxicity in human lymphocytes. The results showed that these agents significantly inhibited cytotoxicity and organelle toxicities induced by titanium dioxide nanoparticles.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2023)
Article
Pharmacology & Pharmacy
Abdollah Arjmand, Elaheh Azizi Javan, Jafar Shahraki, Rozhin Shaboustani, Enayatollah Seydi, Jalal Pourahmad
Summary: CLZ and RIS can cause cytotoxicity on human blood lymphocytes by generating ROS and affecting mitochondrial function. Transplanting lymphocyte mitochondria can protect lymphocytes against the toxicity effects caused by these drugs. Pre-incubation with cytochalasin D can affect the protective effects of mitotherapy in human lymphocytes.
PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ladan Behzadfar, Shokoufeh Hassani, Hossein Feizpour, Nakisa Abbasian, Armin Salek Maghsoudi, Ghorban Taghizadeh, Jalal Pourahmad, Mohammad Sharifzadeh
Article
Environmental Sciences
Emily Curren, Sandric Chee Yew Leong
Summary: Microplastics in marine ecosystems serve as microhabitats for diverse toxic plankton species, including viable resting cysts of dinoflagellates. The diversity of plankton communities on the plastisphere is influenced by anthropogenic factors. This study highlights the importance of plastics as vectors for the transport of harmful opportunistic species in the marine environment.
MARINE ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Vladimir G. Dvoretsky, Alexander G. Dvoretsky
Summary: The Barents Sea, as the largest Arctic shelf region, plays a vital role in supporting commercial fisheries. The ecosystem of this region is significantly influenced by both warm Atlantic Water (AW) and cold Arctic Water (ARW), resulting in distinct frontal zones. This study found that copepod populations, particularly herbivorous copepods, were most abundant and productive in the Polar Front, as well as in the eastern frontal zones. The geographic positions of sampling stations, depth, and chlorophyll a concentration were identified as the main factors influencing copepod biomass and production.
MARINE ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Alberto Rovellini, Charlotte L. Mortimer, Matthew R. Dunn, Elizabeth A. Fulton, Jamaluddin Jompa, Abdul Haris, James J. Bell
Summary: This study compared the structural complexity of coral- and sponge-dominated areas of an Indonesian coral reef using 3D photogrammetry. The results showed that smaller-scale refugia were reduced in sponge-dominated reefs, potentially impacting smaller reef fauna.
MARINE ENVIRONMENTAL RESEARCH
(2024)
