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Chemistry, Medicinal
Min-Ji Ryu, Prima F. Hillman, Jihye Lee, Sunghoon Hwang, Eun-Young Lee, Sun-Shin Cha, Inho Yang, Dong-Chan Oh, Sang-Jip Nam, William Fenical
Summary: New chlorinated meroterpenoids were obtained from a bacterium strain isolated from marine sediment, with compound 3 showing strong antibacterial activities against specific strains.
Article
Chemistry, Multidisciplinary
Anton P. Tyurin, Vera A. Alferova, Alexander S. Paramonov, Maxim V. Shuvalov, Gulnara K. Kudryakova, Eugene A. Rogozhin, Alexander Y. Zherebker, Vladimir A. Brylev, Alexey A. Chistov, Anna A. Baranova, Mikhail V. Biryukov, Igor A. Ivanov, Igor A. Prokhorenko, Natalia E. Grammatikova, Tatyana V. Kravchenko, Elena B. Isakova, Elena P. Mirchink, Elena G. Gladkikh, Elena V. Svirshchevskaya, Andrey V. Mardanov, Aleksey V. Beletsky, Milita V. Kocharovskaya, Valeriya V. Kulyaeva, Alexander S. Shashkov, Dmitry E. Tsvetkov, Nikolay E. Nifantiev, Alexander S. Apt, Konstantin B. Majorov, Svetlana S. Efimova, Nikolai V. Ravin, Evgeny N. Nikolaev, Olga S. Ostroumova, Genrikh S. Katrukha, Olda A. Lapchinskaya, Olga A. Dontsova, Stanislav S. Terekhov, Ilya A. Osterman, Zakhar O. Shenkarev, Vladimir A. Korshun
Summary: A novel family of natural lipoglycopeptides produced by Streptomyces sp. INA-Ac-5812, including gausemycins A and B, have been reported. These compounds exhibit pronounced activity against Gram-positive bacteria and show significant differences in mechanism compared to known glyco- and lipopeptides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Medicinal
Fuhang Song, Jiansen Hu, Xinwan Zhang, Wei Xu, Jinpeng Yang, Shaoyong Li, Xiuli Xu
Summary: Two new cyclized thiolopyrrolone derivatives and one known compound were identified from a marine-derived Streptomyces sp. They exhibited antibacterial activities against different bacteria with varying minimum inhibitory concentrations.
Article
Microbiology
Yi-huang Chen, Yi Zheng Wu, Qin Liu, Zhanfeng Xia, Jianming Wang, Xiao-Xia Luo
Summary: This study focused on the antagonistic strain of Streptomyces against pear black spot disease in Xinjiang. The researchers identified the antibacterial active components of the strain and confirmed its antagonistic activity against Alternaria. The findings are significant for the development of the pear industry and the prevention and control of pear black spot disease in Xinjiang.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Tongxu Cui, Simin Lin, Zizhen Wang, Peng Fu, Cong Wang, Weiming Zhu
Summary: Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F-H (1-3) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380. These compounds showed a selective antiproliferation effect on the acute myeloid leukemia cell line MV4-11.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Dewu Zhang, Xiaoyu Tao, Guowei Gu, Yujia Wang, Wenxia Zhao, Wuli Zhao, Yan Ren, Shengjun Dai, Liyan Yu
Summary: In this study, Biotransformation of the neo-clerodane diterpene scutebarbatine F by Streptomyces sp. CPCC 205437 was investigated for the first time, leading to the isolation of nine new metabolites. These metabolites were characterized using extensive high-resolution mass spectrometry and NMR data analyses. Some of the compounds showed cytotoxic, antiviral, and antibacterial activities.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin-Yi Tang, Chu-Ru Mao, Jie-Bin Fang, Zhong-Jun Ma, Yun Huang, Dan Wang
Summary: Three previously unreported linear polyketide derivatives, Alpiniamides E-G, along with two known compounds, were isolated from Streptomyces sp. QHA48, which was obtained from the saline lakes of Qinghai-Tibet Plateau. The structures of these compounds were elucidated through spectroscopic data analysis, NMR chemical shift calculation using density functional theory, DP4+ algorithm, and electronic circular dichroism (ECD) calculations. In a cell-based lipid-lowering assay, all five alpiniamides demonstrated significant inhibition of lipid accumulation in HepG2 cells at a concentration of 27 μM without inducing cytotoxic effects.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Multidisciplinary Sciences
Monthon Lertcanawanichakul, Tuanhawanti Sahabuddeen
Summary: We characterized Streptomyces sp. KB1 and optimized its cultural conditions. Streptomyces sp. KB1 is a gram-positive and long filamentous bacteria that forms straight to flexuous chains of globose-shaped spores. It can only grow under aerobic conditions within a specific temperature and pH range, and in the presence of sodium chloride.
Article
Chemistry, Medicinal
Se-eun Lee, Min-ju Kim, Prima F. Hillman, Dong-Chan Oh, William Fenical, Sang-Jip Nam, Kyung-Min Lim
Summary: This study found that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect by inhibiting the mRNA expression of melanogenic enzymes, reducing melanin content.
Article
Biotechnology & Applied Microbiology
Byeongsan Lee, Ga-Eun Lee, Gwi Ja Hwang, Kyung Taek Heo, Jae Kyoung Lee, Jun-Pil Jang, Bang Yeon Hwang, Jae-Hyuk Jang, Yong-Yeon Cho, Young-Soo Hong
Summary: The pluramycin family of antibiotics includes angucycline compounds derived from actinomycetes with anticancer and antibacterial properties. Pluramycins have a structural characteristic of two linked aminoglycosides on the γ-pyrone angucycline backbone. Kidamycins and rubiflavins were screened and characterized, and their cytotoxicity against breast cancer cell lines was evaluated. Photokidamycin showed significant inhibition of cell growth in both MCF7 and MDA-MB-231 cells.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Plant Sciences
Abujunaid Khan, Madhukar S. Said, Balasaheb R. Borade, Rajesh Gonnade, Vitthal Barvkar, Ravindar Kontham, Syed G. Dastager
Summary: Three novel compounds and a new acid were identified from the strain Amycolatopsis sp. MCC 0218, and their chemical structures and activities against methicillin-susceptible and -resistant Staphylococcus aureus were determined.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Medicinal
Hyung-Ju Lim, Joon Soo An, Eun Seo Bae, Eunji Cho, Sunghoon Hwang, Sang-Jip Nam, Ki-Bong Oh, Sang Kook Lee, Dong-Chan Oh
Summary: Two strains, Streptomyces sp. GET02.ST and Achromobacter sp. GET02.AC, isolated from the gut of the wharf roach, resulted in the production of new metabolites, ligiamycins A and B, with distinct antibacterial and cytotoxic effects. The structures of ligiamycins were elucidated through spectroscopic analysis, and their relative and absolute configurations were determined using NMR data and optical rotation comparisons.
Article
Biochemistry & Molecular Biology
Maysoon Abdulrahman Al-Zubairy, Khaled Hussein, Salwa H. Alkhyat, Abdullah Yahya Al-Mahdi, Saeed Munassar Alghalibi, Adel Ali Al-Gheethi, Muhanna Mohammed Al-Shaibani, Hesham Ali El Enshasy, Nik Marzuki Sidik
Summary: This study successfully characterized and predicted the antibacterial activity of a novel oligosaccharide from Streptomyces californics against Erwinia carotovora subsp. carotovora using an adaptive neuro-fuzzy inference system and an artificial neural network, providing new insights for potential antimicrobial agent research.
Article
Microbiology
Hisayuki Komaki, Tomohiko Tamura
Summary: This study reclassified several subspecies of Streptomyces into new species based on genetic and phenotypic differences, with the possibility of reclassifying two more subspecies into independent species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Microbiology
Yinan Wang, Di Yang, Yuhui Bi, Zhiguo Yu
Summary: Four new 20-membered macrolides named venturicidins G-J were isolated from a Streptomyces sp. SN5452 culture, along with two known compounds venturicidins A and B. These compounds showed significant inhibition against the growth and germination of Pyricularia oryzae, suggesting their potential as novel fungicides for controlling rice blast.
