Article
Biochemistry & Molecular Biology
Bruno Francesco Rodrigues de Oliveira, Isabelle Rodrigues Lopes, Anna Luiza Bauer Canellas, Guilherme Muricy, Stephen Anthony Jackson, Alan D. W. Dobson, Marinella Silva Laport
Summary: The genome of sponge-associated microorganism Pseudoalteromonas sp. PA2MD11 contains a variety of carbohydrate-active enzymes with potential for degrading marine polysaccharides, including GHs and PLs families. The complete metabolism of agar and alginate by PA2MD11 was predicted, and structural protein analyses showed conservation of catalytic machinery and suitable industrially-relevant features in the enzymes. This bacterium is a potential source of biocatalysts for marine polysaccharide degradation and production of pharmacologically active oligosaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Shuaijun Zan, Jing Wang, Fengbo Wang, Zelong Li, Miaomiao Du, Yingxue Cai
Summary: This study investigated the degradation mechanism of Naphthenic acids (NAs) in marine environments using an indigenous marine Pseudoalteromonas sp. It was found that CHAA could be completely degraded under aerobic conditions but not under anaerobic conditions. The results showed a new anaerobic degradation pathway of NAs, providing new insights into the fate of NAs and other organic contaminants in the marine environment.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Medicinal
Congling Liu, Gong Chen, Hailian Rao, Xun Xiao, Yidan Chen, Cuiling Wu, Fei Bian, Hailun He
Summary: Marine bacterium Pseudoalteromonas sp. JS4-1 was used to produce crude enzymes for hydrolyzing phycobiliprotein. The enzymatic productions showed good performance in scavenging DPPH radical and hydroxyl radical, especially small peptides with MWCO <3 kDa. The second fraction (F2) obtained from size-exclusion chromatography had the highest hydroxyl radical scavenging ability (62.61 +/- 5.80%). Both F1 and F2 exhibited good antioxidant activities in oxidative stress models in HUVECs and HaCaT cells.
Article
Chemistry, Medicinal
Kuei-Hung Lai, Zheng-Hao Huang, Mohamed El-Shazly, Bo-Rong Peng, Wen-Chi Wei, Jui-Hsin Su
Summary: Marine sponges of the genera Geodia, Jaspis, Rhabdastrella, and Stelletta are chemically characterized by a variety of isomalabaricane triterpenes. Two new isomalabaricane-type triterpenes rhabdastin H and rhabdastin I were identified, showing anti-proliferative activities against leukemic cells. These compounds exhibit unique structural features with the only reported tetrahydrofuran functionality among marine-derived isomalabaricanes.
Article
Chemistry, Organic
Kenji Sugawara, Daichi Kanki, Ryuichi Watanabe, Ryoji Matsushima, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Akihiro Ninomiya, Shigeru Okada, Shigeki Matsunaga
Summary: A new cyclic lipopeptide, aciculitin D (1), was isolated from a deep-sea marine sponge, Poecillastra sp. The structure of aciculitin D (1) was determined using spectroscopic analyses and chemical degradation. Compared to aciulitin B, aciculitin D has a substitution of L-Gln for L-Thr in the amino acid sequence. Additionally, the absolute configurations of some residues differ between the two compounds. Aciculitin D (1) exhibits cytotoxicity against HeLa and HCT-116 cells with IC50 values of 4.5 μM and 1.4 μM, respectively.
Article
Oceanography
Fu Wandong, Liao Miaofei, Zhang Dongxu, Zhou Yufang, Yang Huicheng
Summary: The isolated bacterial strain showed the highest bioflocculant production activity at 72 hours, with sucrose and sodium nitrate as the optimal carbon and nitrogen sources, an initial pH of 5.0, and an inoculum size of 3% (v/v). The bioflocculant was mainly composed of 34.3% protein and 63.4% total carbohydrate, and had a higher flocculating activity when Ca2+ was used as the cation.
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2021)
Article
Plant Sciences
Xiao Lin, Zhenzhou Tang, Yuman Gan, Zhengyuan Li, Xiaowei Luo, Chenghai Gao, Longyan Zhao, Ling Chai, Yonghong Liu
Summary: Seven new 18-residue peptaibols, named trichorzins A-G (1-7), were isolated from the sponge-derived fungus Trichoderma sp. GXIMD 01001. Their structures and configurations were characterized using various analytical techniques. The compounds showed significant cytotoxicity against human carcinoma cell lines, but did not exhibit potent antibacterial activity.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features a rare lactone bridge in its unprecedented secomeroterpenoid scaffold. The structure of 1 was determined through extensive spectroscopic analysis, Mosher's method, and electronic circular dichroism calculation. Dysambiol exhibited potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MAKP signaling pathway.
Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MPAK signaling pathway.
Article
Plant Sciences
Qihao Wu, Kurt Throckmorton, Mitasree Maity, Marc G. Chevrette, Doug R. Braun, Scott R. Rajski, Cameron R. Currie, Michael G. Thomas, Tim S. Bugni
Summary: Chemical investigation of a marine sponge-associated Bacillus sp. led to the discovery of bacillibactins E and F, the first bacterial siderophores containing nicotinic and benzoic acid moieties. The structures and absolute configurations of these new compounds were determined through extensive spectroscopic analyses and Marfey's method, with a proposed biosynthetic pathway that differentiates itself by a promiscuous DhbE enzyme.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Multidisciplinary Sciences
Hiromi Watari, Hiromu Kageyama, Nami Masubuchi, Hiroya Nakajima, Kako Onodera, Pamela J. Focia, Takumi Oshiro, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, Takeshi Yokoyama, Makoto Hirayama, Kanji Hori, Douglas M. Freymann, Misa Imai, Norio Komatsu, Marito Araki, Yoshikazu Tanaka, Ryuichi Sakai
Summary: In this study, researchers found that a marine sponge-derived protein can activate the human cytokine receptor MPL, similar to the activation by a molecular chaperone in hematologic malignancies. The sugar-mediated activation of MPL, which is different from the original ligand, suggests that the mode of receptor activation is unpredictably diverse in living organisms.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Marine
Ying Zhou, Huixian Liang, Zhaocong Wang, Xiaojian Liao, Shihai Xu, Bingxin Zhao
Summary: A new cadinene sesquiterpene, Clionaterpene (1), along with six known compounds 2-7, were isolated from the marine sponge Cliona sp. The structure and absolute configuration of compound 1 were determined using spectroscopic data and quantum chemical calculation. The cytotoxic and antibacterial activities of these compounds were evaluated, but none of them showed significant inhibition effects.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Organic
Philipp Moosmann, Tohru Taniguchi, Kazuo Furihata, Hiroaki Utsumi, Yuji Ise, Yasuhiro Morii, Nobuhiro Yamawaki, Tomohiro Takatani, Osamu Arakawa, Shigeru Okada, Shigeki Matsunaga
Summary: Myrindole A, a bis-indole alkaloid isolated from a deep-sea sponge, had a complex structure that was ultimately determined through a combination of experiments and spectral comparison. It showed antimicrobial activity against both Gram-positive and Gram-negative bacteria.
Article
Biochemistry & Molecular Biology
Sophia A. Kolesnikova, Ekaterina G. Lyakhova, Anastasia B. Kozhushnaya, Anatoly I. Kalinovsky, Dmitrii V. Berdyshev, Roman S. Popov, Valentin A. Stonik
Summary: Two new isomalabaricane triterpenoids and four new isomalabaricane-derived nor-terpenoids were isolated in the study, along with the correction in stereochemistry of two known isomalabaricanes.
Article
Microbiology
Mimi Zhang, Qianqian Song, Jin Sang, Zhiyong Li
Summary: A novel bacterial strain, WHS-Z9T, was isolated from a marine sponge collected in Weihai. The strain is motile, short-rod-shaped, and light yellow-pigmented. It has optimal growth conditions at temperatures of 20°C, pH 8.5, and 4% NaCl concentration. Phylogenetic analysis based on the 16S rRNA gene sequence showed that WHS-Z9T is closely related to Brevibacterium limosum o2T. This study proposes classifying WHS-Z9T as a new species of the genus Brevibacterium, named Brevibacterium spongiae sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Rajiv Dahiya, Sunita Dahiya, Jyoti Shrivastava, Neeraj K. Fuloria, Hemendra Gautam, Rita Mourya, Shivkanya Fuloria
Summary: Cyclopolypeptides derived from plant seeds exhibit a wide range of bioactivities, such as estrogenic activity, immunosuppressive activity, cytotoxicity, and vasorelaxant activity. These properties make them attractive leads for drug discovery and provide important insights for the development of novel therapeutics based on a peptide skeleton.
ARCHIV DER PHARMAZIE
(2021)
Review
Biology
Shivkanya Fuloria, Vetriselvan Subramaniyan, Rajiv Dahiya, Sunita Dahiya, Kalvatala Sudhakar, Usha Kumari, Kathiresan Sathasivam, Dhanalekshmi Unnikrishnan Meenakshi, Yuan Seng Wu, Mahendran Sekar, Rishabha Malviya, Amit Singh, Neeraj Kumar Fuloria
Summary: Mesenchymal stem cell extracellular vesicles (MSCEVs) have therapeutic potential for tissue regeneration, but translating preclinical success to clinical applications presents challenges. Modifying stem cell culturing methods and bioengineering EVs can enhance the therapeutic effects of MSCEVs.
Review
Chemistry, Medicinal
Rajiv Dahiya, Sunita Dahiya, Priyank Kumar, Radhika V. Kumar, Saurabh Dahiya, Suresh Kumar, Renu Saharan, Paramita Basu, Arindam Mitra, Ajay Sharma, Sushil K. Kashaw, Jayvadan K. Patel
Summary: Bicyclic peptides, as important molecules in peptide-based drugs, have unique therapeutic potential. Derived from marine resources, they exhibit diverse pharmacological activities, higher conformational rigidity, metabolic stability, as well as antibody-like affinity and specificity.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Organic
Rajiv Dahiya, Sunita Dahiya, Suresh Chennupati, Vernon Davis, Vijaya Sahadeo, Jayvadan K. Patel
Summary: The present investigation focused on synthesizing a novel analogue of a natural marine peptide and evaluating its bioactivity. The synthesized heterocyclic analogue exhibited significant antibacterial, antifungal, and antihelmintic properties. The study demonstrated that solution-phase technique employing carbodiimide chemistry holds potential for synthesizing cycloheptapeptide derivatives.
CURRENT ORGANIC SYNTHESIS
(2022)
Review
Chemistry, Medicinal
Sunita Dahiya, Rajiv Dahiya, Neeraj Kumar Fuloria, Rita Mourya, Saurabh Dahiya, Shivkanya Fuloria, Suresh Kumar, Jyoti Shrivastava, Renu Saharan, Suresh Chennupati, Jayvadan K. Patel
Summary: Bridged peptide macrobicycles (BPMs) from natural resources have not been fully investigated in terms of their formation, pharmacological potential, and stereo-chemical properties. BPMs have advantages over other peptide molecules and show promise as a basis for drug development. However, poor metabolic stability and cell permeability hinder the therapeutic success of macrocyclic peptides. This review comprehensively explores major bicyclic peptides sourced from plants and mushrooms, discussing their unique structural features, synthetic routes, bioproperties, and therapeutic potential.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Ahmed Al-Harrasi, Saurabh Bhtaia, Mohammed Said Al-Azri, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Syam Mohan, Ajay Sharma, Tapan Behl
Summary: Research on composite edible films using chitosan and porphyran loaded with ginger essential oil has shown significant improvements in physical and chemical properties, with enhanced antioxidant potential. This suggests their potential use as packaging materials in the food industry.
Correction
Polymer Science
Ahmed Al-Harrasi, Saurabh Bhtaia, Mohammed Said Al-Azri, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Syam Mohan, Ajay Sharma, Tapan Behl
Article
Pharmacology & Pharmacy
Madhu Gupta, Vikas Sharma, Kalicharan Sharma, Anoop Kumar, Ajay Sharma, Imran Kazmi, Fahad A. Al-Abbasi, Sami Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Gaurav Gupta, Keshav Raj Paudel, Philip M. Hansbro, Kamal Dua
Summary: The present study developed a new type of nanoparticles for targeted delivery of anticancer drugs to tumor cells. The nanoparticles showed high cytotoxicity and significantly inhibited tumor growth, highlighting the importance of rational nanoparticle design.
Article
Pharmacology & Pharmacy
Abhishek Tiwari, Varsha Tiwari, Ajay Sharma, Deependra Singh, Manju Singh Rawat, Tarun Virmani, Reshu Virmani, Girish Kumar, Manish Kumar, Abdulsalam Alhalmi, Omar M. Noman, Ramzi A. Mothana, Mohammad Alali
Summary: Uterine fibroids, a common gynecological disorder, affect 25-35% of women and may require surgery for treatment. In this study, 28 plant-based molecules were docked onto progesterone receptors, and Tanshinone-I showed the best docking score. Molecular modeling and DFT analysis confirmed the stable interaction between Tanshinone-I and the progesterone receptor. Free energy analysis revealed a favorable binding energy for Tanshinone-I. These findings suggest the potential of Tanshinone-I as a therapeutic option for uterine fibroids.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Varsha Tiwari, Abhishek Tiwari, Ajay Sharma, Manish Kumar, Deepak Kaushik, Suresh Sagadevan
Summary: Alzheimer's disease causes neurodegenerative effects on mental ability, dementia, and behavioral changes, which can be observed years before symptoms appear. The lack of validated biomarkers presents a challenge for early diagnosis and management. However, advancements in nanotechnology offer potential solutions through inexpensive screening and targeted drug delivery using nanoparticles. These nanoparticles can efficiently cross the blood-brain barrier, and their improved characteristics make them useful for early diagnosis. This review provides comprehensive information on AD and its management, with a focus on nanotechnology advancements and various nanomedicine strategies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nikita Kaushal, Manish Kumar, Abhishek Tiwari, Varsha Tiwari, Kamini Sharma, Ajay Sharma, Arya Lakshmi Marisetti, Madan Mohan Gupta, Imran Kazmi, Sami Alzarea, Waleed Hassan Almalki, Gaurav Gupta
Summary: This study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. The optimized in situ gel showed superior ex vivo transcorneal permeation with zero-order kinetics, making it a promising candidate for treating anterior uveitis.
Review
Pathology
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Neeraj Kumar Fuloria, Mahendran Sekar, Dhanalekshmi Unnikrishnan Meenakshi, Lakshmi Thangavelu, Ajay Sharma
Summary: Lung cancer is a significant medical burden globally, and long non-coding RNAs (lncRNAs) play a crucial role in its development. This article reviews the key components of the MAPK pathway and the aberrant signaling processes associated with lung cancer, providing insights into the regulatory role of lncRNAs in MAPK signaling.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Polymer Science
Amit Budhori, Abhishek Tiwari, Varsha Tiwari, Ajay Sharma, Manish Kumar, Girendra Gautam, Tarun Virmani, Girish Kumar, Abdulsalam Alhalmi, Omar Mohammed Noman, Sidgi Hasson, Ramzi A. Mothana
Summary: Traditional otic drug delivery methods lack controlled release capabilities, making reverse gelatination gels a promising alternative. This study successfully developed thermosensitive norfloxacin reverse gelatination gels using a Quality by Design (QbD)-based optimization approach. The selected formulation, F10, exhibited desirable properties in terms of gelling temperature, drug content, and release profile.
Review
Integrative & Complementary Medicine
Khalid Saad Alharbi, Yogendra Singh, Gopal Prasad Agrawal, Waleed Mohammad Altowayan, Waleed Hassan Almalki, Ajay Sharma, Sachin Kumar Singh, Niraj Kumar Jha, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: Lymphopenia is frequently observed in COVID-19 patients, particularly those with severe disease, and is associated with a decrease in CD28 expression on naive T cells. Combining COVID-19 vaccination with SARS CoV2-reactive naive T cells that express the CD28 immune molecule may be a viable method for establishing T-cell-based, adaptive cellular immunotherapy against COVID-19 infection.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Varsha Tiwari, Abhishek Tiwari, Anita Singh, Navneet Verma, Manish Kumar, Ajay Sharma
Summary: This study demonstrates the significant antidiabetic activity of Bryophyllum cpinnatum stems and identifies its key phytoconstituents through fingerprinting analysis. Both alcohol and aqueous extracts show antidiabetic potential in animal models, with zinc sulfate enhancing the efficacy of the alcohol extract.
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)