期刊
MARINE DRUGS
卷 12, 期 6, 页码 3283-3291出版社
MDPI AG
DOI: 10.3390/md12063283
关键词
Streptomyces sp.; violapyrones; anti-cancer activity; alpha-pyrones; starfish
资金
- Korea Institute of Ocean Science and Technology [PE99273]
- Ministry of Oceans and Fisheries, Korea [PM57561]
Two new alpha-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI(50) values of 1.10-26.12 mu g/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据