期刊
MARINE DRUGS
卷 12, 期 7, 页码 3929-3952出版社
MDPI
DOI: 10.3390/md12073929
关键词
marine natural products; aquaculture; microbial symbionts; marine invertebrates; pharmaceuticals
资金
- PhD scholarship - Fundacao para a Ciencia e Tecnologia [SFRH/BD/63783/2009]
- National Fund for Scientific Research (FNRS) [F3/5/5-A2/5-MCF/DM-A115]
- EU [KBBE-2010-266033]
- European Funds through COMPETE
- National Funds through the Portuguese Science Foundation (FCT) [PEst-C/MAR/LA0017/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63783/2009] Funding Source: FCT
The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the. blue gold. in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据