期刊
MARINE DRUGS
卷 13, 期 1, 页码 128-140出版社
MDPI
DOI: 10.3390/md13010128
关键词
Streptomyces zhaozhouensis; ikarugamycin; polycyclic tetramate macrolactams; antifungal; antibacterial
资金
- European Union [312184]
- Ministerio de Ciencia e Innovacion [PCT-010000-2010-4, INP-2011-0016-PCT-010000-ACT6]
A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
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