Article
Biochemistry & Molecular Biology
Yang Liu, Zhenzhen Deng, Jingjing Zhang, Yumeng Wu, Ning Wu, Lihua Geng, Yang Yue, Quanbin Zhang, Jing Wang
Summary: A novel dual-functional hydrogel dressing (DPH20) is developed for the treatment of diabetic foot ulcers. DPH20 exhibits good swelling property and exudate absorption ability, and accelerates wound healing through mechanisms such as accelerated macrophage recruitment, promotion of angiogenesis, and growth factor release.
Article
Biochemistry & Molecular Biology
Hui Zhan, Gang Yu, Mingjing Zheng, Yanbing Zhu, Hui Ni, Tatsuya Oda, Zedong Jiang
Summary: The low-molecular-weight saccharide fragment LMWAs-H from the sulfated polysaccharide ascophyllan of Ascophyllum nodosum exhibited potent inhibition activity against alpha-glucosidase, but mild inhibition on alpha-amylase, which is likely due to its structural properties.
Article
Chemistry, Applied
Meijia He, Jiejie Hao, Changning Feng, Yajing Yang, Zhuling Shao, Lei Wang, Wenjun Mao
Summary: OHSS2, a polysaccharide derived from green alga Cladophora oligoclada, possesses strong anti-diabetic activity by protecting mitochondria from hIAPP aggregation-induced damage and regulating mitochondrial function.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Anton B. Rasin, Natalia M. Shevchenko, Artem S. Silchenko, Mikhail Kusaykin, Galina N. Likhatskaya, Tatyana N. Zvyagintseva, Svetlana P. Ermakova
Summary: This study investigated the structure of two fucoidans from Fucus evanescens algae using NMR spectroscopy and examined the effects of fucoidan/chitosan mass ratio on the properties of nanoparticles. Molecular docking and thermodynamic analysis revealed significant conformational changes of the molecules during binding, potentially enhancing binding effectiveness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yuanping Hao, Weiping Zheng, Zhanyi Sun, Demeng Zhang, Kunyan Sui, Peili Shen, Peifeng Li, Qihui Zhou
Summary: Marine polysaccharide-based hydrogels have attracted attention for biomedical applications due to their excellent properties. These hydrogels, composed of chitosan, alginate, or fucoidan, can be easily prepared with tunable microporous architecture, swelling, and biodegradable properties. They exhibit high mechanical strength and excellent cytocompatibility, blood compatibility, and histocompatibility, making them promising bioscaffolds in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Mingfei Guo, Jiarong Gao, Lei Jiang, Yaji Dai
Summary: Diabetic nephropathy is a chronic inflammatory complication of diabetes characterized by hyperglycemia, albuminuria, and edema. Astragalus polysaccharide, extracted from Astragalus membranaceus, has been used for the treatment of diabetes mellitus. This study aimed to investigate the molecular mechanism of Astragalus polysaccharide on diabetic nephropathy. The results demonstrated that Astragalus polysaccharide effectively reduced fasting blood glucose levels, improved kidney function, and alleviated renal pathological damage in diabetic nephropathy models.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yanli Zhu, Lubin Liu, Zhanyi Sun, Yanjing Ji, Danyang Wang, Li Mei, Peili Shen, Zhixin Li, Shang Tang, Hui Zhang, Qihui Zhou, Jing Deng
Summary: Fucoidan, a marine-origin prebiotic, has been shown to affect the responses of Lactobacillus rhamnosus, with high-temperature autoclave treatment causing depolymerization of fucoidan. The proliferation, morphology, and metabolism of probiotics are dependent on fucoidan concentrations, with an increased concentration leading to reduced formation of probiotic biofilm and variable antibacterial ability. These findings provide new insights into probiotic modulation and the potential application of fucoidan in inhibiting bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Soojeong Cho, Le Thi Thuy, Sangwon Ko, Yeonwoo Jeong, Sung Min Kang, Joon Sig Choi, Woo Kyung Cho
Summary: The researchers developed a direct method to fabricate antifouling polysaccharide coatings that can hinder bacterial adhesion and growth. Fucoidan catechol (FD-C), a conjugate of fucoidan and catechol groups, was co-sprayed with ferric (Fe-III) ions to form coordination-driven antifouling coatings on surfaces. The FD-C/Fe-III coatings achieved significant reduction in E. coli and S. aureus adhesion. The spray-based coatings also exhibited long-term durability and flexibility for various substrates.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Immunology
Hailin Huang, Fangze Guo, Xuyang Deng, Mingzhe Yan, Danyang Wang, Zhanyi Sun, Changqing Yuan, Qihui Zhou
Summary: Fucoidan has immunomodulatory effects on macrophages, neutrophils, and natural killer cells. It also promotes T cell proliferation and affects osteogenesis. This research provides new insights into the interplay between fucoidan, T cells, and osteoblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Akanksha Dubey, Jayanthi Sivaraman
Summary: Inflammation is a preliminary immune response to harmful stimuli, and lipoxygenases are involved in inflammatory reactions. Fucoidan, a sulphated polysaccharide, is being studied for its potential in treating inflammatory diseases. This study investigated the inhibitory effects of fucoidan on lipoxygenase and found that it has anti-inflammatory potentials.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
D. L. Bellan, I. H. Bini, F. C. Santi, G. R. Rossi, S. M. P. Biscaia, A. I. Maximo, M. B. Reis, F. F. Simas, C. C. Oliveira, S. M. B. Winnischofer, D. M. Leme, R. Chammas, H. A. O. Rocha, E. S. Trindade
Summary: Despite advances in targeted and immunotherapy, effective treatment for metastatic melanoma remains challenging with limited success and severe adverse effects. This study explored the potential of a sulfated fucoidan called Fucan A, obtained from brown seaweed, as an antimelanoma drug. Fucan A showed selective antiproliferative effects on melanoma cells, reduced colony formation and invasive capacity, and modulated invasion-related genes. It also reduced in vivo tumor volume and pulmonary metastasis colonization with minimal adverse effects. These findings suggest that Fucan A has potential as a promising antimelanoma drug candidate.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Chemistry, Medicinal
Ling Qin, Hui Xu, Yingying He, Chen Liang, Kai Wang, Junhan Cao, Changfeng Qu, Jinlai Miao
Summary: An immunomodulatory polysaccharide (DAP4) was extracted from Durvillaea antarctica, which was identified as a fucoidan. DAP4 showed excellent immunomodulatory activity, promoting the proliferation of spleen lymphocytes, increasing NO production, enhancing phagocytic activity of macrophages, and improving the vitality of NK cells.
Article
Biochemistry & Molecular Biology
Ling Qin, Junhan Cao, Hui Xu, Nianxu Li, Kai Wang, Liping Zhang, Changfeng Qu, Jinlai Miao
Summary: A sulfated polysaccharide (IOY) from the brown alga Ishige okamurae Yendo, identified as a fucoidan, was isolated and characterized. IOY showed potent immunomodulatory effects in vitro and in vivo, including increasing spleen and thymus indexes, alleviating chemotherapeutic-induced damage, promoting hematopoietic function recovery, and enhancing immune response. IOY could be a promising candidate for drug development or application in functional foods to counteract chemotherapy-induced immunosuppression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Md. Akibul Hasan Bakky, Ngoc Tuan Tran, Ming Zhang, Yongsheng Zhang, Huifen Liang, Yilei Wang, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Summary: This study characterized the polysaccharide from Gracilaria lemaneiformis and investigated its fermentation by rabbitfish intestinal microbes. The study found that the polysaccharide was mainly composed of galactose and anhydrogalactose, and it enhanced the production of short-chain fatty acids and altered the gut microbiota. The findings suggest that the polysaccharide has prebiotic potential and could be used as a functional feed additive in aquaculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Bilal Muhammad Khan, Li-Xin Zheng, Wajid Khan, Aftab Ali Shah, Yang Liu, Kit-Leong Cheong
Summary: This study filled the gap in the physical and chemical characterization of Gracilaria blodgettii polysaccharides, revealing its antioxidant potential and potential applications in the functional food industry.
Article
Biochemistry & Molecular Biology
Fei-Fei Geng, Zhe Jiang, Yong-Hu Chen, Ning Li, Xue-Zheng Li
Summary: A chemical investigation of Angelica acutiloba identified 26 compounds, including 11 coumarins, 11 phthalides, one sterol, two polyacetylenes, and one bisbenzopyran. Several of these compounds were isolated for the first time from specific sources.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Agricultural Engineering
Ning Yang, Xueru Sheng, Liting Ti, Haiyuan Jia, Qingwei Ping, Ning Li
Summary: This paper investigates the ball-milling process for biodiesel production using Kraft lignin activated carbon stabilized K2CO3. The biodiesel yield increased to 66% within 5 minutes and reached 100% within 25 minutes under optimal ball-milling conditions. Additionally, the power demand of the ball-milling method was found to be lower than the traditional thermocatalytic method. Therefore, the ball-milling method is an effective and economical process for biodiesel production.
BIORESOURCE TECHNOLOGY
(2023)
Article
Environmental Sciences
Xiaojuan Chen, Yu Zhou, Jiesen Li, Suresh C. Pillai, Nanthi Bolan, Juhua He, Ning Li, Song Xu, Xin Chen, Qinghua Lin, Hailong Wang
Summary: Biochar obtained from pyrolysis of biomass waste has the potential to be used in wastewater treatment due to its large surface area and active sites. In this study, biochar was prepared from sorghum straw and its adsorption kinetics towards tartrazine was investigated. The optimized biochar was also used as a catalyst for peroxydisulfate activation to degrade tartrazine. The degradation pathways and reactive substances were analyzed, showing the potential ecological benefits of this catalytic system.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Multidisciplinary
Ning Li, Tiantian Zhang, Zuliang Wu, Jing Li, Wei Wang, Jiali Zhu, Shuiliang Yao, Erhao Gao
Summary: The synergistic effects of Sn and Ag in the 1Sn5Ag/gamma-Al2O3 catalyst greatly enhance its C3H6-SCR performance. The presence of AgCl crystallites helps maintain an appropriate redox ability and suppresses over-oxidation of C3H6. The coexistence of Ag and Sn increases the reactivity of surface adsorbed oxygen and hydroxyl groups, and the electron transfer effects increase the ratio of Ag-0/Ag+.
Article
Engineering, Aerospace
Xibin Cao, Ning Li, Shi Qiu, Chaoyong Li
Summary: This paper proposes a scheduling method based on grids coding for searching and tracking time-sensitive targets in a region. It assesses the observation problem and constructs a grids coding model for observation resources and tasks. A dynamic updating process of probability is established, taking into account the movement of the time-sensitive target, and a dynamic prediction model of target position is founded, considering the unpredictability of the time-sensitive target model. Ultimately, a mega-constellation searching technique is developed with the enhancement of information entropy of covering grids as the objective function.
AEROSPACE SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Zhihao Zhang, Meng Li, Tong Yang, Zixi Zang, Ning Li, Ronger Zheng, Jinjia Guo
Summary: Research on the transient variation processes of oceanic dissolved CO2 is significant due to the complexity and dynamics of the marine environment. However, the response performance limitation of in situ sensors poses challenges. This study presents a novel system solution that overcomes this limitation, enabling high-performance detection with a seconds-scale response, sub-ppmv level precision, and 3000 m rated depth. By improving the response performance of the sensor, the water mixing process and concentration variation profile can be accurately portrayed, offering insights into carbon cycle research in deep-sea unstable regions.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xingfan Gong, Jiacheng Xu, Tiantian Zhang, Yan Sun, Shiyu Fang, Ning Li, Jiali Zhu, Zuliang Wu, Jing Li, Erhao Gao, Wei Wang, Shuiliang Yao
Summary: Cu-doped manganese oxide (Cu-Mn2O4) prepared using aerosol decomposition showed excellent CO oxidation performance. The 0.5Cu-Mn2O4 catalyst with a hollow sphere morphology and high Mn3+, Cu+, and Oads ratios exhibited the best CO oxidation activity, with low T-50 and T-90 values. DRIFTS-MS analysis revealed that terminal-type oxygen (M=O) and bridge-type oxygen (M-O-M) on 0.5Cu-Mn2O4 were reactive at low temperatures and water had limited inhibitory effects on CO oxidation.
Article
Construction & Building Technology
Ning Li, Zuquan Jin, Kai Shen, Guangcheng Long, Yong Yu, Qiang Fu, Chuansheng Xiong, Bo Pang, Xiaoying Zhang
Summary: Three strategies, including rubber particles, steel fibers, and asphalt-coated coarse aggregate, were introduced to enhance the impact resistance of self-compacting concrete after freeze-thaw cycles. The impact compression properties of the modified concrete were evaluated using a split Hopkinson pressure bar. Modifying materials showed a significant strain rate effect on the dynamic properties of the concrete. The addition of modifying materials resulted in a lower decrease in the fineness modulus of residue and an improved impact toughness index, indicating reduced damage caused by freeze-thaw cycles and enhanced impact resistance.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Engineering, Marine
Yuchang Zhi, Jiemin Zhan, Renfang Huang, Yiwei Wang, Ning Li
Summary: This paper investigates the dynamic behavior of ventilated supercavities considering the effect of the free surface through numerical simulations. The presence of the free surface affects the length and diameter of the ventilated cavity, as well as the vertical velocity distribution between the free surface and the cavity. Two typical gas leakage mechanisms, namely the twin-vortex tube leakage mode and the re-entrant jet leakage mode, were observed at different immersion depths. The internal flow field of the ventilated supercavity can be classified into three regions: the internal boundary layer, the ventilation influence region, and the reverse flow region. The ventilated supercavity is influenced by both the free surface effect and the gravity effect as the distance between the free surface and the cavity decreases.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Medicinal
Heng Zhang, Xiao Guo, Di Zhou, Jiatong Wen, Yingzhan Tang, Jian Wang, Yang Liu, Gang Chen, Ning Li
Summary: In this study, a visible-light-induced intermolecular [2 + 2] photocycloaddition reaction was used to synthesize 20 derivatives of (perpendicular to)-millpuline A for bioactivity evaluation. The protective effects of (+/-)-millpuline A and compound B13a against NNK-induced lung cell injury were revealed. The target of (+/-)-millpuline A was determined to be SRC protein, and its inhibitory effect on SRC activity was demonstrated through a transcriptional mechanism. These findings provide valuable insights for the further development of flavonoids and understanding the bioactivity and mechanism of (+/-)-millpuline A.
Article
Materials Science, Composites
Ning Li, Saeed Ahmed Khan, Kun Yang, Kai Zhuo, Yixia Zhang, Hulin Zhang
Summary: A thermogalvanic organohydrogel electrolyte (OHE) was developed with Sn2+/Sn4+ as a redox couple and NaCl as an additional electrolyte, enabling interactions between visually impaired people, normal people, and auxiliary devices. The OHE exhibits favorable mechanical and thermoelectric performances, with a high Seebeck coefficient of -1.62 mV/K. It can withstand harsh environments with its anti-freezing, non-drying properties and wide working temperature range (-20 to 60 degrees C), and was successfully integrated into a self-powered Braille transmission interface for real-time Braille transmission and readout.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Computer Science, Information Systems
Bing Xia, Shengpu Li, Ning Li, Hong Li, Xuguang Tian
Summary: This study improves the Serre standard model and proposes a method to effectively identify the surface defects of solar panels. By combining pre-processing and binary image processing, the features of solar panels are obtained and classified using the improved model, achieving high accuracy in defect recognition.
Article
Engineering, Electrical & Electronic
Jiang Mai, Sha Guijun, Li Ning
Summary: This paper proposes an infrared and visible image fusion algorithm based on guided filter and dual-tree complex wavelet transform, which overcomes the limitations of traditional image fusion algorithms and improves target clarity, edge and texture details, and contrast. The visible and high-frequency infrared image components are enhanced using guided filter, based on the characteristics of infrared and visible images. Then, an algorithm based on saliency adaptive weighting rules is used to fuse low-frequency subband components, and a rule based on Laplace energy sum and gradient value vector is used to fuse high-frequency subbands at different scales and directions. Finally, the fused coefficients are inverted using dual-tree complex wavelet transform to obtain the final reconstructed image. Experimental results demonstrate the improved performance of the proposed algorithm in terms of objective evaluation indicators, with clear target features, background texture, edge details, and appropriate overall contrast.
LASER & OPTOELECTRONICS PROGRESS
(2023)
Review
Chemistry, Multidisciplinary
Xiaoyu Zhang, Ning Li, Guorui Wang, Chi Zhang, Yu Zhang, Fanglei Zeng, Hailong Liu, Gang Yi, Zhongwei Wang
Summary: Flexible human body electronic sensors with flexibility, extensibility, and responsiveness are highly desirable. Polysiloxane materials have become the preferred choice as a flexible matrix for their good affinity towards the human body.
Proceedings Paper
Computer Science, Artificial Intelligence
Liying Yu, Peng Wang, Zhe Chen, Dewen Li, Ning Li, Rachid Cherkaoui
Summary: This paper presents a distributed shadow dynamic consensus (DSDC) framework to address the generation company (GENCO) strategic bidding problem in the independent system operator (ISO) operation. The framework uses a distributed dynamic consensus algorithm to estimate the general equality constraint and obtain optimal locational marginal prices (LMP) and power allocation. The proposed framework is tested using the IEEE 30-bus test system.
2023 IEEE PES CONFERENCE ON INNOVATIVE SMART GRID TECHNOLOGIES, ISGT MIDDLE EAST
(2023)