Predictive Factors of Sensitivity to Elisidepsin, a Novel Kahalalide F-Derived Marine Compound

Phase I study of PM02734: Association of dose-limiting hepatotoxicity with plasma concentrations

(2017) J. Y. Bruce et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I study of elisidepsin (E) in combination with carboplatin (C) in patients (pts) with advanced solid tumors.

(2017) S. J. Faivre et al.   JOURNAL OF CLINICAL ONCOLOGY

Epithelial-Mesenchymal Transition Markers and HER3 Expression Are Predictors of Elisidepsin Treatment Response in Breast and Pancreatic Cancer Cell Lines

(2013) Cristina Teixidó et al.   PLoS One

PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase

(2011) Yi-He Ling et al.   CLINICAL CANCER RESEARCH

ErbB protein modifications are secondary to severe cell membrane alterations induced by elisidepsin treatment

(2011) Tímea Váradi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

(2011) José M. Molina-Guijarro et al.   PLoS One

Epithelial-to-Mesenchymal Transition and Oncogenic Ras Expression in Resistance to the Protein Kinase C  Inhibitor Enzastaurin in Colon Cancer Cells

(2010) M. Serova et al.   MOLECULAR CANCER THERAPEUTICS

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells

(2009) A. Ghoul et al.   CANCER RESEARCH

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models

(2009) Yi-He Ling et al.   EUROPEAN JOURNAL OF CANCER

Levels of SCS7/FA2H-Mediated Fatty Acid 2-Hydroxylation Determine the Sensitivity of Cells to Antitumor PM02734

(2008) A. B. Herrero et al.   CANCER RESEARCH

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

(2008) Michèle Sabbah et al.   DRUG RESISTANCE UPDATES