期刊
MARINE DRUGS
卷 11, 期 6, 页码 2230-2238出版社
MDPI AG
DOI: 10.3390/md11062230
关键词
sediment; Penicillium pinophilum; secondary metabolite; brine shrimp lethality
资金
- Ministry of Science and Technology [2013AA092901, 2010CB833802]
- National Natural Science Foundation of China [31270403]
Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 mu M.
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