期刊
MARINE DRUGS
卷 11, 期 1, 页码 40-49出版社
MDPI AG
DOI: 10.3390/md11010040
关键词
antibacterial; antinematode; functional genomic screen; fosmid libraries; marine bacteria; marine bioactives; Caenorhabditis elegans
资金
- Australian Research Council
- Centre for Marine Bio-Innovation
- University International Postgraduate Award
A common limitation for the identification of novel activities from functional (meta) genomic screens is the low number of active clones detected relative to the number of clones screened. Here we demonstrate that constructing libraries with strains known to produce bioactives can greatly enhance the screening efficiency, by increasing the. hit-rate. and unmasking multiple activities from the same bacterial source.
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