期刊
MARINE DRUGS
卷 10, 期 4, 页码 932-952出版社
MDPI
DOI: 10.3390/md10040932
关键词
bostrycin; synthesis; antitumor; derivatives; structure-activity relationship
资金
- National Natural Science Foundation of China [20972197, 41176128]
- 863 Foundation of China [2011AA09070201]
- Key Science and Technique Research Project of Guangdong Province of China [2010B030600003, 2010B030600004, 2011A080403006]
- National Science and Technique Major Project [2012ZX09102-101-017]
- University-industry Cooperation Projects of Guangdong Province
- Ministry of Education [2008B090500171]
- Guangzhou Project of Science & Technology Planning [2010J1-E331]
A series of new derivatives (5-29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据