期刊
MARINE DRUGS
卷 10, 期 9, 页码 2126-2137出版社
MDPI
DOI: 10.3390/md10092126
关键词
Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity
资金
- National Research Foundation of Korea (NRF)
- Korean government (MEST, Ministry of Education, Science and Technology) [20120006709]
Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.
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