☆ 4.7 Article

Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

MARINE DRUGS (2012)

期刊

MARINE DRUGS

卷 10, 期 5, 页码 1092-1102

出版社

MDPI

DOI: 10.3390/md10051092

关键词

cell cycle arrest; ascidians; staurosporine

类别

Chemistry, Medicinal Pharmacology & Pharmacy

资金

CNPq
CAPES
InCB
FAPESP

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Protocol

Reagent

摘要

The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.

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