Article
Chemistry, Medicinal
Adrian Krzyzanowski, Axel Pahl, Michael Grigalunas, Herbert Waldmann
Summary: The spatial score (SPS) is an empirical scoring system that expresses the spatial complexity of a compound in a uniform and granular manner. It can differentiate natural products and synthetic compounds and is applicable in the analysis of biological activity data.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Fumiaki Nakamura, Hiroshi Kimura, Nobuhiro Fusetani, Yoichi Nakao
Summary: Two previously unreported onnamide analogs, 2Z- and 6Z-onnamides A (1 and 2), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. The structures of compounds 1 and 2 were determined by spectoral analysis. They exhibited structure-activity relationships in histone modifications and cytotoxicity against HeLa and P388 cells.
Article
Chemistry, Multidisciplinary
Hong-Quan Xu, Huan Xiao, Jin-Hui Bu, Yan-Feng Hong, Yu-Hong Liu, Zi-Yue Tao, Shu-Fan Ding, Yi-Tong Xia, E. Wu, Zhen Yan, Wei Zhang, Gong-Xing Chen, Feng Zhu, Lin Tao
Summary: The study introduces a comprehensive database for endophytic microorganism natural products (EMNPD), which aims to meet the increasing demand for data mining and sharing in this field. This database provides a wealth of natural product data and links to other databases, facilitating drug discovery and exploration of bioactive substances.
JOURNAL OF CHEMINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Chi-Jen Chang, Yen-Ling Hung, Ting-Chen Chen, Hsin-Ju Li, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung
Summary: Hispidulin selectively inhibits the viability of melanoma cells, induces apoptosis, reduces cell migration, and inhibits tumor growth in xenograft models. These findings suggest that hispidulin may be a potential candidate for melanoma treatment.
Article
Food Science & Technology
Bing Xu, Shengjun Wu
Summary: Fucoidan coatings have the ability to extend the shelf life of mango fruits, with the best results observed at the highest concentration.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Zoology
Alan Dias, Michelle Kelly, Ulisses Pinheiro
Summary: In this study, two new species of Corallistidae from Brazil are described and compared to all valid species of the respective genera. These findings are significant as they represent the first records of Neophrissospongia Pisera and Levi, 2002 from the Brazilian coast and Awhiowhio Kelly, 2007 from the Atlantic Ocean. The specimens were preserved in 80% ethanol and analyzed using classical procedures for Demospongiae, including dissociated spicule mounts, skeletal sections, and Scanning Electron Microscopy. Neophrissospongia jorgeorum sp. nov. is distinguished from its congeners by the types of spicules present, particularly the absence of streptasters/amphiasters. Awhiowhio saci sp. nov. is characterized by the presence of spiraster-shaped microrhabds and microxeas.
Review
Biotechnology & Applied Microbiology
Amir Y. Alwali, Elizabeth Parkinson
Summary: Actinobacteria are a significant group of bacteria that produce important bioactive compounds. Environmental factors and small molecule elicitors can induce the production of secondary metabolites from actinobacteria, especially those that are typically undetectable.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Shani Shoham, Adi Weinberger, Aviv Kaplan, Dror Avisar, Micha Ilan
Summary: Arsenic contamination of freshwater resources is a major global environmental issue, but bacteria associated with the Red Sea sponge show potential for reducing arsenic contamination in low-salinity liquid medium. Alteromonas macleodii and Pseudovibrio ascidisceicola have demonstrated high rates of arsenic reduction, indicating promising bioremediation potential.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Pharmacology & Pharmacy
Seyeon Park, Joomin Lee
Summary: Natural products have been used to promote hair growth safely and effectively, providing a potential solution for hair loss. Commercial products based on these natural ingredients have shown promise in treating alopecia. Studies have focused on the mechanisms underlying the hair-growth-promoting effects of plant-derived biochemicals.
Article
Biochemistry & Molecular Biology
Melissa M. Cadelis, Hugo Gordon, Alex Grey, Soeren Geese, Daniel R. Mulholland, Bevan S. Weir, Brent R. Copp, Siouxsie Wiles
Summary: Fungi are a valuable source of bioactive natural products, and a recent study on Neodidymelliopsis sp. led to the discovery of several new compounds, including a polyketide that is sensitive to environmental conditions. Additionally, it was confirmed that pachybasin is biosynthesized through the acetate polyketide pathway.
Review
Biochemistry & Molecular Biology
Li-Li Ren, Xiao-Jun Li, Ting-Ting Duan, Zheng-Hai Li, Jun-Zheng Yang, Ya-Mei Zhang, Liang Zou, Hua Miao, Ying-Yong Zhao
Summary: Fibrosis is the excessive deposition of extracellular matrix components in the processes of tissue repair, causing organ structural integrity and functional impairment. Transforming growth factor-beta (TGF-beta) is a key factor in promoting fibrosis by activating profibrotic signals. This review discusses the role of TGF-beta signaling in fibrotic organs, as well as potential therapeutic options for targeting tissue fibrosis through modulating TGF-beta signaling.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Multidisciplinary Sciences
Vincent Libis, Logan W. MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A. Ternei, Niv Antonovsky, Jan Burian, Zongqiang Wang, Sean F. Brady
Summary: The study presents a parallelized method for identifying, mobilizing, and heterologously expressing bacterial gene clusters (BGCs), leading to the discovery of therapeutically relevant bioactive molecules. The approach efficiently localizes clones carrying intact BGCs, resulting in the identification of several natural products.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Samar M. Abdelrahman, Nastassia Patin, Amro Hanora, Akram Aboseidah, Shimaa Desoky, Salha G. Desoky, Frank J. Stewart, Nicole B. Lopanik
Summary: Bacteria associated with marine nudibranchs show potential as a rich source of bioactive compounds and natural product biosynthetic genes. Some of these bacteria exhibit antimicrobial and antitumor activities, and they contain gene clusters for natural product biosynthesis.
Review
Biochemistry & Molecular Biology
Siti Nuurul Huda Mohammad Azmin, Nur Solehin Sulaiman, Mohd Shukri Mat Nor, Palsan Sannasi Abdullah, Zulhisyam Abdul Kari, Siddhartha Pati
Summary: This article reviews the application of plant pigments in food products, including the functions of primary plant dyes, extraction methods, and the importance of natural pigments in the food industry. Future challenges in utilizing natural pigments are also discussed.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ran Wen, Jianmei Lv, Penghui Jia, Wenjing Yang, Na Wang, Xiuwen Wu, Zhong Xue, Yuan Liu
Summary: The study revealed that tunicatachalcone (TC) could alleviate neuroinflammation induced by microglia through the inhibition of RIPK2. This finding provides a new therapeutic target for neurologic disorders associated with inflammation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)