Article
Pharmacology & Pharmacy
Didem Deliorman Orhan, Nilufer Orhan, Ozge Demir, Belma Konuklugil
Summary: The study evaluated the total phenolic content, in vitro antidiabetic, and antioxidant potential of marine organisms from the Mediterranean coast, highlighting Dysidea avara as a potential new natural source for the treatment of diabetes mellitus due to its strong inhibitory activity on alpha-glucosidase enzyme.
Article
Multidisciplinary Sciences
Wenming Zhu, Qishuang Yin, Zhizheng Lou, Ming Yang
Summary: trans-Clerodanes and sesquiterpene (hydro)quinones are a class of natural products featuring the same trans-decalin core. This study reports the total syntheses of these compounds via a modular synthetic route and reveals a wrong structural assignment for the natural product dysidavarone D.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Gizem Kaya, Baris Kiskan, Recep Isci, Mehmet S. Eroglu, Turan Ozturk, Yusuf Yagci
Summary: The study presents a novel strategy for fabricating electro-responsive polybenzoxazine based high-performance thermoset surfaces. Three structurally different benzoxazines were coated as thin films on ITO electrodes and cured by thermal activation. Structural characteristics, thermal behavior, electrochemical properties, and surface properties were evaluated using various techniques. This work demonstrates a straightforward electrochemical method for tuning surface morphology and hydrophilicity through redox processes and hydrogen bonding interactions.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Tatjana P. Stanojkovic, Marina Filimonova, Nadja Grozdanic, Slavica Petovic, Anna Shitova, Olga Soldatova, Alexander Filimonov, Jelena Vladic, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Marina Nikitovic
Summary: This study aimed to investigate the activity of avarol, a sesquiterpene hydroquinone found in the Dysidea avara sponge, against various cancer cell lines and mouse carcinomas. The results showed significant cytotoxicity of avarol against the investigated cell lines in vitro, and potent antitumor activity in vivo against two mouse tumor models.
Article
Engineering, Environmental
Lei Xu, Yuting Wang, Erqun Song, Yang Song
Summary: In this study, PBDE-Qs and PBDE-HQs were synthesized and their nucleophilic and redox properties were investigated. It was found that PBDE-Qs react with GSH leading to neurotoxic effects, while PBDE-HQs do not have this capability. EPR analysis revealed the generation of SQ(center dot-) by PBDE-Qs which contributes to their toxicity, especially in PBDE-Q/HQ compounds with bromine substitution on the quinone ring.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Applied
Isabelle Heing-Becker, Katharina Achazi, Rainer Haag, Kai Licha
Summary: The synthesis and characterization of responsive cyanine dyes operating in the near-infrared based on the use of the hydroquinone/quinone and catechol/quinone couple is reported. These dyes can globally or specifically image reducing environments species in biological settings. The introduction of a hydroquinone group into the dye allows for modulation of fluorescence through oxidation and reduction, enabling rapid on-off-on switching in response to relevant reducing species in living cells.
Article
Chemistry, Multidisciplinary
Yu Lei, Boao Li, Xiaojian Liao, Xiwen Xing, Pengju Feng, Bingxin Zhao, Shihai Xu
Summary: A new piperidone alkaloid, dysidone A (1), was isolated from the marine sponge Dysidea sp. and its total synthesis was achieved. The compound showed weak anti-inflammatory activity.
Article
Electrochemistry
Abhishek Kumar, Nada Alami-Mejjati, Marcel Bouvet, Rita Meunier-Prest
Summary: The electrooxidation process of gallic acid (GA) in an aqueous medium was reexamined using cyclic voltammetry and spectroelectrochemical studies on a gold electrode. The results revealed that the redox process of GA is an irreversible two-electron process, with the formation of ortho-quinone as the final product. The acidity constant of the ortho-quinone was determined for the first time (pKa = 5.33). The number of exchanged electrons and protons depended on the pH conditions, with (2e, 2H+) exchanged at pH < 4.24 and pH > 5.33, and (2e, 1H+) exchanged at 4.24 < pH < 5.33. The existence of a DISP2 mechanism leading to the formation of ortho-quinone through disproportionation of semiquinone radicals was demonstrated.
ELECTROCHIMICA ACTA
(2023)
Article
Nanoscience & Nanotechnology
Puttipong Pananusorn, Araya Ruengsuk, Andrew Docker, Korawit Khamphaijun, Kitima Sirivibulkovit, Mongkol Sukwattanasinitt, Jonggol Tantirungrotechai, Phoonthawee Saetear, Taweetham Limpanuparb, Thanthapatra Bunchuay
Summary: A novel quinhydrone-type complex between pillar[5]quinone (P[5]Q) and hydroquinone (HQ) is reported, which exhibits high stability and can be used for the selective liquid-liquid extraction and recovery of HQ.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Yitian Su, Hongmin Jiang, Qiaoling Kang, Xianhe Meng, Xiaomei Zheng, Jianfei Lu, Xingkun Mei, Xiangdong Sun, Lijing Yan, Tingli Ma
Summary: This article introduces the design of an all-organic aqueous battery and discusses the challenges of selecting suitable electrolytes and active materials. By experimenting with the combination of hydroquinone derivatives and anthraquinone as the cathode and anode, along with a weak acid metal-ion aqueous electrolyte, it is found that AQ-tetra-chlorohydroquinone-Al2(SO4)3 exhibits optimal performance. Through electrochemical and structural characterizations, the underlying work mechanism of this battery configuration is revealed, showing the involvement of H+ and Al3+ ions in the redox reaction of quinone electrodes, with Al3+ playing a crucial role. This work inaugurates a new framework for designing all-organic aqueous batteries.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Applied
Barbara N. Gimenez, Leandro O. Conte, Francesca Audino, Agustina V. Schenone, Moises Graells, Orlando M. Alfano, Montserrat Perez-Moya
Summary: A kinetic model for the photo-Fenton degradation of Paracetamol (PCT) was proposed, considering the effects of radiation absorption. Irradiated experiments achieved a high PCT conversion and mineralization rate. Kinetic parameters were estimated and the model successfully predicted the concentrations of reaction intermediates. The photo-Fenton process proved to generate non-toxic effluent.
Article
Biochemistry & Molecular Biology
Md Harunur Rashid, Dinesh Babu, Arno G. Siraki
Summary: NQO1 and NQO2 are important antioxidant enzymes that reduce the generation of harmful quinone-like compounds through two-electron reduction, playing a crucial role in oxidative stress. Studies have shown that induction or depletion of NQO1 and NQO2 can affect susceptibility to oxidative stress. These enzymes play critical roles when other detoxification pathways are overwhelmed.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Medicinal
Zongchen Ma, Wenjie Zhang, Xiao Han, Guoqiang Li
Summary: In this study, a total of 45 nitrogenous stilbenes were designed, synthesized, and tested for their cytotoxic activities against two human tumor cell lines and a normal cell line. The structure-activity relationships revealed that the introduction of N,N-dimethylamino enhanced the cytotoxicity towards one cell line, while compounds with N-methyl piperazine displayed stronger potency towards another cell line. Compound NS1i exhibited extremely potent cytotoxicity against one cell line and selective toxicity towards normal cells. In addition, in silico target prediction and molecule docking suggested a potential target for NS1i. Overall, nitrogenous stilbenes show promising potential as anticancer agents, with NS1i as a promising lead for further investigation.
Article
Chemistry, Multidisciplinary
Shelby L. Hooe, Emma N. Cook, Amelia G. Reid, Charles W. Machan
Summary: The H(2)Q/BQ redox couple shows mechanistic parallels to ubiquinone in the electron transport chain, and has applications in catalytic reactions and energy storage. Hydrogen-bonded quinone anions can undergo two-electron reduction and proton transfer at high proton concentrations.
Article
Electrochemistry
Noufal Merukan Chola, Rajaram K. Nagarale
Summary: A quinone-containing methylene bridged COF was developed as an electrode material for aqueous zinc-based storage device, demonstrating excellent stability and enhanced electrochemical performance with controlled dendrite formation in a silica dispersed electrolyte. Carbon nanotubes loaded during the synthesis further improved the electrochemical characteristics of the material.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
