Review
Chemistry, Medicinal
Mariana C. Almeida, Diana I. S. P. Resende, Paulo M. da Costa, Madalena M. M. Pinto, Emilia Sousa
Summary: This review highlights the potential of marine alkaloids derived from tryptophan as antimicrobial agents, discussing their importance in drug discovery, current research progress, and future prospects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Minghui Fan, Liangbang Zou, Kaidi Tian, Guoqing Chen, Kai Cheng, Yong Li
Summary: This review provides a comprehensive coverage of stemmadenine alkaloids from early reports to July 2022, and briefly describes their diverse biological activities. Furthermore, the proposed biosynthetic pathway for stemmadenine and the conversion of stemmadenine-type alkaloids into vallesamine-type congeners are discussed in detail. Additionally, successful synthetic strategies to access the strained stemmadenine scaffolds are fully reviewed.
NATURAL PRODUCT REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Tian-Yun Jin, Ping-Lin Li, Ci-Li Wang, Xu-Li Tang, Mei-Mei Cheng, Yuan Zong, Lian-Zhong Luo, Hui-Long Ou, Ke-Chun Liu, Guo-Qiang Li
Summary: The study isolated new racemic and dimeric indole alkaloids from a cultured sponge, with one of the compounds, (+)-spondomine, showing cytotoxicity against K562 cell line and stronger signaling inhibitory activity. All stereoisomers significantly promoted angiogenesis and exhibited moderate anti-inflammatory effects. Quantum chemical calculations and deuteration experiments were used to guide the synthesis of the target compounds.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jong-Duk Park, Yuchen Li, Kyuho Moon, Esther J. Han, Seoung Rak Lee, Mohammad R. Seyedsayamdost
Summary: The study reports eight novel and architecturally unusual secondary metabolites synthesized by the bacterial symbiont Phaeobacter inhibens, which may originate from their algal hosts in a natural setting. Some of these metabolites exhibit potent algaecidal activity, providing important implications for the parasitic phase of algal-bacterial symbiotic interactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Medicinal
Jin Yang, Lizhi Gong, Miaomiao Guo, Yu Jiang, Yi Ding, Zhijie Wang, Xiujuan Xin, Faliang An
Summary: Six new prenylated indole diketopiperazine alkaloids, along with eight known analogues, were isolated from the marine-derived endophytic fungus Aspergillus sp. YJ191021. Compound 1 exhibited moderate antifungal, antibacterial, and anti-inflammatory activities, indicating its potential as a bioactive compound.
Review
Biochemistry & Molecular Biology
Andre G. Tempone, Pauline Pieper, Samanta E. T. Borborema, Fernanda Thevenard, Joao Henrique G. Lago, Simon L. Croft, Edward A. Anderson
Summary: This review focuses on the biological activity of marine alkaloids towards Neglected Tropical Diseases (NTDs) caused by protozoan parasites, and malaria, covering the period from 2000 up to 2021. It highlights the potential of marine alkaloids in academic drug discovery programs, offering a different resource to discover new chemical entities with new modes of action.
NATURAL PRODUCT REPORTS
(2021)
Article
Microbiology
Dongli Lv, Jinmei Xia, Xiaoqing Guan, Qiliang Lai, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun, Jiang-Jiang Qin, Weiyi Wang
Summary: Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Pan-Pan Fu, Qun Wang, Qing Zhang, Yang Jin, Jin Liu, Kai-Xian Chen, Yue-Wei Guo, San-Hong Liu, Xu-Wen Li
Summary: The total synthesis and structure modification of the marine natural product naamidine J were achieved based on structure-relationship analyses. These compounds were tested for their ability to inhibit PD-L1 protein expression in human colorectal adenocarcinoma cells. Compound 11c efficiently suppressed PD-L1 expression in cells and exhibited antitumor effects in mice by reducing PD-L1 expression and enhancing T-cell immunity. This research may contribute to the discovery of new tumor immunological drug leads derived from marine natural products.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Mei-Jun Chu, Meng Li, He Ma, Ping-Lin Li, Guo-Qiang Li
Summary: This review highlights the chemical structure and biological activity of 355 compounds isolated and characterized from Agelas sponges over the period of about five decades. These compounds are classified and summarized based on their carbon skeleton and biosynthetic origins. The review underscores Agelas sponges as an intriguing source for the discovery of natural compounds.
Article
Microbiology
An Xu, Xiang-Nan Xu, Mi Zhang, Chun-Lian Li, Li Liu, De-Yuan Fu
Summary: This study discovered new biologically active compounds from a marine deep-sea-derived fungus, which possess unique structures and show broad-spectrum anti-tumor activity. The results suggest that one of these compounds may have potential for future drug development.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joana D. M. de Sa, Decha Kumla, Tida Dethoup, Anake Kijjoa
Summary: Fungi, the second most species-rich organism group, can grow in various habitats and provide a rich source of biologically active natural products. Although there is a large diversity of fungal species, only a small fraction of them have been studied so far.
Article
Chemistry, Organic
Wen-Tao Zhu, Chen Chen, Qian Zhao, Ling-Ling Han, Min Yang, Xiao-Jiang Hao, Yu Zhang
Summary: Tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids with rare skeleton characterized by a quinuclidine moiety, were isolated from the stems of Tabernaemontana divaricata. Their structures and absolute configurations were elucidated through extensive analysis of MS, NMR, ECD, and X-ray diffraction, and a possible biogenetic pathway of 1 was also proposed.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Physical
G. Jeyanthi, C. Gnana Sambandam
Summary: The optimized geometry and vibrational wave numbers of Benzoguanamine (BG) normal modes were investigated using Gaussian'09 at B1B95/6-31 G (d) level. The study elucidated the structural and spectral analysis of the compound, as well as molecular docking with target proteins to confirm biological activity and drug likeness influences.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Dawn Su -Yin Sim, Sin-Yee Tang, Yun-Yee Low, Siew-Huah Lim, Toh-Seok Kam
Summary: Thirteen indole alkaloids were isolated from the leaf extract of Tabernaemontana corymbosa sample from Taiping, Perak, Malaysia. The structures of these alkaloids were determined, and a possible biogenetic pathway was proposed.
Article
Chemistry, Medicinal
Joko Tri Wibowo, Peni Ahmadi, Siti Irma Rahmawati, Asep Bayu, Masteria Yunovilsa Putra, Anake Kijjoa
Summary: Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been extensively studied. Indole alkaloids, as one of the most promising compounds, possess diverse biological/pharmacological activities. This review summarizes the indole alkaloids isolated from 2016 to 2021 and their relevant biological/pharmacological activities, describing a total of 186 indole alkaloids.
Article
Chemistry, Applied
Guilherme Venancio Simaro, Marivane Lemos, Jonas Joaquim Mangabeira da Silva, Wilson Roberto Cunha, Luiza Junqueira Carneiro, Sergio Ricardo Ambrosio, Nayanne Larissa Cunha, Sergio Faloni de Andrade, Caroline Arruda, Vilmar C. Bandero-Filho, Astrid Sasse, Helen Sheridan, Jairo Kenupp Bastos, Marcio Luis Andrade e Silva
Summary: Copaifera pubiflora Benth oleoresin (CPO) possesses anti-inflammatory and antinociceptive activities without cytotoxic effects.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Katia Aparecida de Siqueira, Rhavena Graziela Liotti, Ana Helena Januario, Lucas Campos Curcino Vieira, Ana Paula de Araujo Boleti, Edson Lucas dos Santos, Marcos Antonio Soares
Summary: The actinobacterium Streptomyces griseocarneus R132 was found to produce 4-chlorocinnamic acid, which could effectively inhibit the growth of Colletotrichum gloeosporioides and reduce the lesions caused by the phytopathogen in fruits.
BIOCONTROL SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Marcio L. A. e Silva, Rodrigo Lucarini, Fransergio F. dos Santos, Carlos H. G. Martins, Patricia M. Pauletti, Ana H. Januario, Mario Ferreira Conceicao Santos, Wilson R. Cunha
Summary: The infusion extract of commercially available O. vulgare leaves has been shown to have hypoglycemic activity, potentially due to the combined effect of rosmarinic acid and other minor compounds. This supports the folkloric use of O. vulgare as an antidiabetic herbal medicine.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Thais C. Lima, Lizandra G. Magalhaes, Lucas A. de L. Paula, Wilson R. Cunha, Ana H. Januario, Patricia M. Pauletti, Jairo K. Bastos, Fransergio F. dos Santos, Moacir R. Forim, Rosangela S. Laurentiz, Fernanda A. Santos, Renato P. Orenha, Renato L. T. Parreira, Carlos A. Fuzo, Eduardo F. Molina, Mario F. C. Santos, Marcio L. A. e Silva
Summary: The study demonstrated that the preparation of poly-epsilon-caprolactone nanoparticles can achieve slow release of lignan dinitrohinokinin, with smaller diameter nanocapsules with negative surface charge providing good stability. In in vivo experiments, nanoencapsulated dinitrohinokinin significantly reduced the number of Schistosoma mansoni in the liver and spleen.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Analytical
Luzio G. Bocalon, Marcos G. Tozatti, Ana H. Januario, Patricia M. Pauletti, Marcio L. A. Silva, Lucas A. Rocha, Eduardo F. Molina, Mario F. C. Santos, Wilson R. Cunha
Summary: Drug delivery systems are technologies that have been extensively studied and applied to enhance the application of existing drugs and improve the bioavailability of compounds of interest. This study successfully incorporated betulinic acid (BA) into mesoporous silica materials and investigated the characteristics and release mechanisms of the nanoparticles. The results demonstrate the potential use of these nanoparticles in drug delivery systems.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Applied
Icaro E. F. Da Silva, Daniela G. Zoca, Gabriela N. Andrade e Silva, Albert Katchborian-Neto, Pedro S. dos S. R. Cavallari, Samarah G. de Almeida, Ana H. Januario, Patricia M. Pauletti, Joao Victor Andrade, Raquel P. Morais-Urano, Wilson Roberto Cunha, Mario F. C. Santos, Marcio L. A. e Silva
Summary: This study demonstrates the analgesic and anti-inflammatory properties of hydroalcoholic extracts from the Handroanthus impetiginosus plant, commonly known as 'Ipe roxo' in Brazil. The extracts showed significant anti-inflammatory activity in mice and potent analgesic action in a hot plate test. Analysis of the extracts identified various metabolites, indicating their potential as complementary herbal medicine for pain and inflammation disorders.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Sandra Vaz Soares Martins, Angelica Cristina Coelho Britto, Marcos Gomide Tozzati, Lizandra Guidi Magalhaes, Marcio Luis Andrade e Silvaa, Ana Helena Januario, Patricia Mendonca Pauletti, Antonio Eduardo Miller Crotti, Amanda Vargas dos Passos, Ester Goncalves de Jesus, Amanda Diniz Peixoto, Gabriela dos Santos Medeiros, Mario F. C. Santos, Wilson Roberto Cunha
Summary: Neglected tropical diseases are a major cause of death and disability in developing countries. This study aimed to identify the major constituents of Capsicum frutescens and Capsicum baccatum fruit extracts and evaluate their schistosomicidal, leishmanicidal, and trypanocidal activities. The results showed that C. frutescens extracts had better activity, possibly due to higher concentrations of capsaicin (1). Capsaicin (1) exhibited significant trypanocidal activity with an IC50 value of 6.23 mu M, suggesting it as a potential active constituent.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Roberta Lopes Mariano, Daniel Luiz Montagnini, Hallana Alves Manuquian, Albert Katchborian-Neto, Pedro Sandoval dos Santos Ribeiro Cavallari, Samarah Gomes de Almeida, Ana Helena Januario, Patricia Mendonca Pauletti, Lizandra Guide Magalhaes, Camila de Paula Ferreira da Silva, Othon Souto Campos, Wilson Roberto Cunha, Mario Ferreira Conceicao Santos, Marcio Luis Andrade e Silva
Summary: This study investigates the antileishmanial activity of different extracts of Handroanthus impetiginosus and reveals its chemical composition. The leaf and seed ethanolic extracts show significant inhibitory effects on leishmaniasis, and various active compounds are identified.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Pharmacology & Pharmacy
Joao Paulo Campos Andrade, Osvaine Junior Alvarenga Alves, Marian Caroline Costa, Valeria Maria Melleiro Gimenez, Iara Silva Squarisi, Heloiza Diniz Nicolella, Mariana Cintra Pagotti, Denise Crispim Tavares, Wilson Roberto Cunha, Marcio Luis Andrade e Silva, Ana Helena Januario, Lizandra Guidi Magalhaes, Patricia Mendonca Pauletti
Summary: Adenocalymma axillarum, a traditional medicinal plant, has leishmanicidal activity. Analysis of the leaf ethanol crude extract revealed the presence of flavonoids. Isolated compounds from the extract were found to be inactive against the parasites and cells.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Luis C. Kellner Filho, Rhenner N. A. Assis, Aline O. dos Santos, Sabrina K. Targanski, Katia A. Siqueira, Livia S. de Medeiros, Celio F. F. Angolini, Felipe M. A. da Silva, Marcos A. Soares, Gustavo M. Dias, Marcio L. A. Silva, Wilson R. Cunha, Patricia M. Pauletti, Hector H. F. Koolen, Ana H. Januario
Summary: Ambuic acid (AA) is a promising antivirulence drug candidate, mainly produced by species of Pestalotiopsis. Through NMR spectroscopy and LC-MS/MS-based molecular networking, new AA derivatives were identified in the study.
