Article
Engineering, Chemical
Ibrar Ibrar, Lilyan Alsaka, Sudesh Yadav, Ali Altaee, John L. Zhou, Ho Kyong Shon
Summary: This study proposes a biodegradable gravity-driven kappa-Carrageenan-vanillin hydrogel for biologically treated leachate wastewater treatment, reducing cost and brine management issues.
Article
Chemistry, Analytical
D. Nanda Kumar, Zina Baider, Daniel Elad, Shlomo E. Blum, Giorgi Shtenberg
Summary: This paper presents a reflective-based method for detecting and estimating the activity of BoNT/C. The method utilizes two adjacent porous Si Fabry-Pe 'rot interferometers to quantify minute BoNT/C concentrations and assess their endopeptidase activity. The optical assay is highly sensitive, and the specificity and selectivity of the method are validated. In real-life scenarios, the method demonstrates excellent compliance for complex media analysis.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xinning Liu, Menghan Wu, Chenchen Li, Peng Yu, Shanshan Feng, Yanwei Li, Qingzhu Zhang
Summary: This study systematically investigated the adsorption potential of heavy metals with amino acids using Density Functional Theory method. It revealed the contribution order of amino acid side chains to the binding affinity and the affinity order of heavy metal cations. The significant influence of water environment on the structures and binding energies of the complexes was also confirmed.
Article
Chemistry, Analytical
Jieun You, Seungki Lee, Hyun Jin Tark, Min Jeong Nang, Ji Hyeon Oh, Inhee Choi
Summary: This study demonstrates a simple optical method for detecting Cu2+ using plasmonic sugar nanoprobes composed of gold nanoparticles and polysaccharides. Cu2+ can be easily detected below the international standard level by optimizing the experimental conditions.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Juanjuan Zhao, Feng Deng, Han Zhang, Wenwen Gu, Huidan Chen, Siqi Huang
Summary: This paper studies the redistribution law of heavy metals in the process of sludge disintegration to address the problems of excess sludge output, difficulty in treatment and disposal, and potential toxicity of heavy metals limiting resource utilization. The dissertation investigates the distribution law of Cu, Pb, Cd, Zn in the process of microwave and citric acid-microwave cracking sludge under different specific energy conditions. The findings show that the dissolution rate of heavy metals increased rapidly during the citric acid-microwave cracking process, and the concentrations and stability of heavy metals in the sludge were affected by specific energy and treatment methods.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Wanqiang Wang, Wenzheng Tang, Xiaoping Wang, Wen Liu, Fen Zhu
Summary: The study found that regulating the expression levels of CPA1, GST2, and CYTb-c1 genes through RNA interference can reduce the accumulation of Pb in the larvae of houseflies. These proteins play crucial roles in Pb transport and detoxification in M. domestica larvae.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Inorganic & Nuclear
Kyangwi P. Malikidogo, Manon Isaac, Adrien Uguen, Jean-Francois Morfin, Gyula Tircso, Eva Toth, Celia S. Bonnet
Summary: In this study, a new ligand was designed as a Zn2+-responsive MRI contrast agent for Zn2+ detection in HSA. The selectivity and increased affinity of the ligand were confirmed through a series of experiments, allowing for a better understanding of the rigidity effect of Zn2+ on the system.
INORGANIC CHEMISTRY
(2023)
Article
Environmental Sciences
Cheng Peng, Huijuan Song, Zixin Zhao, Xiaolin Kuang, Yuanlong Wang, Shaoning Chen, Youzheng Chai, Ma Bai, Liang Peng
Summary: A field experiment was conducted to investigate the effectiveness and mechanisms of foliar spraying of a transpiration inhibitor (TI) and different amounts of rhamnolipid (Rh) on reducing the Cd content in rice grain. It was found that the combined application of TI and 1Rh significantly reduced the Cd concentration in rice grain to meet the national food safety requirements. This method holds potential for safe food production in Cd-polluted soils.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Materials Science, Multidisciplinary
Yuxi Chao, Mengqi Zhao, Qingqing Guan, Hao Guo, Dejun Chen, Xiaoqing Ma
Summary: Suspension curing technology was used to recover heavy metals from sewage and synthesize adsorptive/catalytic dual-system materials. The maximum adsorption capacities of Cu2+ and Mn3+ were high, and the calcined products showed strong catalytic property and water resistance.
Review
Environmental Sciences
Melvin S. Samuel, Saptashwa Datta, Rahul Sampat Khandge, Ethiraj Selvarajan
Summary: Metallothioneins (MTs), small metalloproteins with cysteine residues, have various functions including metal binding, metal homeostasis, and protection against heavy metals. They are studied as a promising solution for heavy metal contamination and utilized as bio-environmental markers for predicting contamination levels. The structural and chemical characterization of MTs, along with techniques for quantification and purification, have been extensively explored in various fields.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Maria del Carmen Nunez-Santiago, Artemio Perez-Lopez, Teodoro Espinosa-Solares, Maria Ines Nicolas-Vazquez, Bernabe Laureano-Lopez
Summary: The gelation and melting temperatures of calcium-induced ?-carrageenan gels were measured, and the theoretical interactions between dimeric unit models of ?-carrageenan and Ca2+ ions were analyzed. The addition of CaCl2 increased the gelation and melting temperatures, indicating thermal hysteresis. The study showed that ?-carrageenan can form intra- and intermolecular hydrogen bonding and coordinate with Ca2+ ions, suggesting that the coil-helix transition is promoted by Ca2+ ions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jianwei Shi, Xiaoxu Teng, Quanling Suo, Amin Mojiri, Mohsen Taghavijeloudar, Shahabaldin Rezania
Summary: A novel magnetic microbead adsorbent (M-PES-PEI) containing magnetic iron oxide, polyethersulfone, and polyethyleneimine was developed for the removal of lead ions (Pb2+) from drinking water. Characterization of the M-PES-PEI microbeads was done using SEM, EDX, and FTIR techniques. The experimental conditions were optimized, and a 91% removal of Pb2+ was achieved using 50 mg of microbeads. Adsorption models based on isotherms, kinetics, and thermodynamics were applied, and the pseudo-second-order kinetic model and Freundlich isotherm model showed good fitting with the experimental data.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Inorganic & Nuclear
Noushaba Nusrat Mafy, Dorothea B. Hudson, Emily L. Que
Summary: Metalloenzymes play important roles in living organisms, but the number of FDA-approved metalloenzyme inhibitors is limited. Light-controlled inhibition provides a precise way to regulate metalloenzyme activity. This review summarizes the strategies for developing biocompatible light-sensitive inhibitors for metalloenzymes and discusses the photophysical mechanisms and interaction modes of these inhibitors.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Environmental Sciences
Kaouthar Feki, Sana Tounsi, Moncef Mrabet, Haythem Mhadhbi, Faical Brini
Summary: The toxicity of metals negatively impacts plants' growth and productivity, leading to various disruptions. Plants employ efficient mechanisms through signaling pathways to combat this stress, involving metal transporters and metal-binding proteins for detoxification. Further research on the molecular basis of metal toxicity and tolerance mechanisms is crucial for genetic engineering to produce transgenic plants that enhance phytoremediation techniques.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Kazuko Yui, Hidetoshi Kuramochi, Masahiro Osako
Summary: This study evaluated the performance of multizonal thermodynamic equilibrium calculation in waste incineration by comparing results with incineration tests and literature information. The calculation successfully reproduced the gas phase chemical speciation of heavy metals in the incinerator expected from high temperature properties but did not match the measured fly ash speciation. Possible reasons for these inconsistencies were considered.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2021)
Review
Chemistry, Applied
Maxim Khotimchenko, Vladlena Tiasto, Aleksandra Kalitnik, Maria Begun, Rodion Khotimchenko, Ekaterina Leonteva, Igor Bryukhovetskiy, Yuri Khotimchenko
CARBOHYDRATE POLYMERS
(2020)
Review
Biochemistry & Molecular Biology
M. Khotimchenko
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Medicinal
Antonina Klimenko, Robin Huber, Laurence Marcourt, Estelle Chardonnens, Alexey Koval, Yuri S. Khotimchenko, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Vladimir L. Katanaev
Summary: The discovery of a novel cytotoxic porphyrin compound with potential anti-TNBC activity from the ethanol extract of the North Pacific brittle star Ophiura sarsii may lead to the development of targeted natural-based therapies for breast cancer. The compound, (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid, was isolated using a bioguided approach and possesses strong cytotoxic properties. Porphyrins have not been previously identified in Ophiuroidea and have wide applications in anticancer photodynamic therapy.
Article
Pharmacology & Pharmacy
Maksim Khotimchenko, Victor Antontsev, Kaushik Chakravarty, Hypatia Hou, Jyotika Varshney
Summary: The study successfully predicted the transdermal disposition of opioid analgesics in human subjects using an artificial intelligence-integrated biosimulation platform, and evaluated the safety of using these drugs in patients with skin injuries through the predicted plasma levels of the analgesics.
Article
Biochemistry & Molecular Biology
Kaushik Chakravarty, Victor G. Antontsev, Maksim Khotimchenko, Nilesh Gupta, Aditya Jagarapu, Yogesh Bundey, Hypatia Hou, Neha Maharao, Jyotika Varshney
Summary: The COVID-19 pandemic has affected over 100 million people worldwide, prompting the need for accelerated development of anti-viral drugs. Studies have shown that a combination of ACE inhibitors and CCBs may have therapeutic relevance in COVID-19.
Article
Marine & Freshwater Biology
V. V. Kovalev, E. Khozhaenko, E. A. Podkorytova
Summary: The poorly esterified pectin isolated from seagrass Phyllospadix iwatensis was modified using acidic hydrolysis and showed improved sorption capacity for strontium and yttrium ions, indicating potential applications in metal ion removal.
RUSSIAN JOURNAL OF MARINE BIOLOGY
(2021)
Article
Genetics & Heredity
Anna Solovyeva, Ivan Levakin, Evgeny Zorin, Leonid Adonin, Yuri Khotimchenko, Olga Podgornaya
Summary: This study traced the clonal diversity of trematode larvae using the SAFLP method and identified repetitive elements in the genome and transcriptome data. The majority of sequenced fragments contained the reverse transcriptase domain of LINEs, with the discovery of a new CR1-renegade (CR1-rng) fragment as well. The discussion around the role of CR1 in clonal diversity was also highlighted in the findings.
Review
Biochemistry & Molecular Biology
Rodion Khotimchenko, Igor Bryukhovetskiy, Maksim Khotimchenko, Yuri Khotimchenko
Summary: The study reviews the outcomes of screening studies of natural compounds with high anti-glioma activity, emphasizing the potential for greater diversity of marine compounds and likelihood of finding effective molecules. It covers the main problems of glioma chemotherapy and provides information on at least 15 classes of organic compounds with their chemical formulas and pharmacokinetic profiles. The taxonomic diversity of marine species containing bioactives with antiglioma activity is analyzed, noting cytotoxicity indicators and comparing them to similar indicators of antitumor agents for clinical use.
Article
Biochemistry & Molecular Biology
Antonina Klimenko, Elvira E. Rodina, Denis Silachev, Maria Begun, Valentina A. Babenko, Anton S. Benditkis, Anton S. Kozlov, Alexander A. Krasnovsky, Yuri S. Khotimchenko, Vladimir L. Katanaev
Summary: Photodynamic therapy (PDT) is a powerful anticancer treatment that relies on the use of photosensitizers. This study identifies ETPA as a major metabolite of the North Pacific brittle stars and demonstrates its strong phototoxicity against cancer cell lines in vitro. In a mouse model of glioblastoma, ETPA injection combined with red laser irradiation induces necrotic ablation of the brain tumor.
Review
Chemistry, Medicinal
Yuri S. Khotimchenko, Denis N. Silachev, Vladimir L. Katanaev
Summary: Neurodegenerative diseases are becoming a major health issue, with marine pharmacology offering a potentially rich source of novel compounds for drug discovery. The Russian Pacific has the potential to be a treasure trove for marine-based drug development targeting neurodegenerative diseases.
Article
Chemistry, Medicinal
Vladlena A. Tiasto, Nikolay V. Goncharov, Alexander O. Romanishin, Maxim E. Zhidkov, Yuri S. Khotimchenko
Summary: In this study, kappa o- and lambda o- oligosaccharides from the marine algae Chondrus armatus were isolated, purified and structurally characterized. The tumor suppressive activity of these carrageenans was examined in gastrointestinal cancer models, showing pronounced antiproliferative effects and cell cycle inhibition in cancer cells. Furthermore, the carrageenans induced apoptosis in adenocarcinomas. These results highlight the potential of kappa o- and lambda o- carrageenans for drug development in colon and esophageal carcinoma.
Article
Biochemistry & Molecular Biology
Antonina Klimenko, Robin Huber, Laurence Marcourt, Dmitry Tabakaev, Alexey Koval, Salim Sh. Dautov, Tatyana N. N. Dautova, Jean-Luc Wolfender, Rob Thew, Yuri Khotimchenko, Emerson Ferreira Queiroz, Vladimir L. L. Katanaev
Summary: Through metabolite analysis, we have identified five new chlorin compounds from Ophiura sarsii and O. ooplax, demonstrating their potential applications in photodynamic therapy.
