Article
Fisheries
Maria Mastoraki, Lydia Katsika, Paula Enes, Ines Guerreiro, Yannis P. Kotzamanis, Laura Gasco, Stavros Chatzifotis, Efthimia Antonopoulou
Summary: This study investigated the possibility of using insect larvae meals to replace fish meal in gilthead sea bream feed. The results showed that the use of Tenebrio molitor larvae resulted in better growth performance, while Hermetia illucens meal had lower dry matter-fat retention.
Article
Geriatrics & Gerontology
J. P. P. Richie Jr, R. Sinha, Z. Dong, S. N. Nichenametla, G. P. Ables, A. Ciccarella, I. Sinha, A. M. Calcagnotto, V. M. Chinchilli, L. Reinhart, D. Orentreich
Summary: Restricting dietary intake of methionine and cysteine can delay the aging process, improve glucose and fat metabolism, and reduce oxidative stress. This study found that feeding restricted methionine or total sulfur amino acids diets to healthy adults had no adverse effects and significantly improved biomarkers of cardiometabolic disease risk. These findings suggest the potential for further clinical development of this intervention.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Nutrition & Dietetics
Zhen Dong, John P. Richie, Xiang Gao, Laila Al-Shaar, Sailendra N. Nichenametla, Biyi Shen, David Orentreich
Summary: Excess intake of sulfur amino acids is associated with a higher risk of type 2 diabetes. Dietary patterns low in sulfur amino acids could help prevent type 2 diabetes.
JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Ying Tian, Yuping Huan, Lihong Chen, Suwen Peng, Zhiyan He, Qian Wang
Summary: Excess weight and obesity lead to abnormal fat accumulation in skeletal muscles, affecting muscle quality and glucose uptake. Combining high protein intake with energy restriction can reduce fat content, but the mechanisms behind the effects on protein and fat content are not well understood.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Sudeshna Banerjee, Zulhisyam Abdul Kari, Guillermo Tellez-Isaias, Koushik Ghosh
Summary: This study explores the potential use of solid state fermentation (SSF) of linseed oil cake (LOC) for non-conventional carp diets. SSF improved protein content and amino acids while reducing crude fiber and anti-nutritional factors in the feed. Diets with 30% fermented LOC showed better growth performance, increased enzyme activity, and improved blood parameters in fish.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Nutrition & Dietetics
Zhen Dong, Xiang Gao, Vernon M. Chinchilli, Raghu Sinha, Joshua Muscat, Renate Winkels, John P. Richie
Summary: The study found that high-SAA diets are associated with increased risk for diabetes mortality, and lowering intake towards Recommended Dietary Allowance levels could lead to reductions in lifetime risk.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Alyssa Paoletti, Paul B. Pencharz, Ronald O. Ball, Dehan Kong, Libai Xu, Rajavel Elango, Glenda Courtney-Martin
Summary: This study determined the total sulfur amino acid (TSAA) requirement in older adults and found that the requirement is significantly higher in older men compared to older women.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Plant Sciences
William M. Singer, Zachary Shea, Dajun Yu, Haibo Huang, M. A. Rouf Mian, Chao Shang, Maria L. Rosso, Qijan J. Song, Bo Zhang
Summary: This study identified genomic associations and evaluated the potential for genomic selection for methionine content in soybean seeds. Several novel SNPs associated with methionine content were identified, and the use of a subset of these SNPs improved the prediction accuracy for methionine content compared to using the complete set of SNPs. This research has important implications for soybean breeding.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Chemistry, Medicinal
Kanwal Mahmood, Ashkan Emadi
Summary: Metabolic reprogramming contributes to tumor development and leads to metabolic vulnerabilities that can be targeted in cancer treatment. Alterations in fatty acid, folate, and amino acid metabolism pathways have been identified in hematological malignancies, providing new opportunities for developing novel cancer therapies targeting these pathways. Glutamine depletion and inhibition of the one-carbon metabolism are also being explored as potential therapeutic strategies for cancers dependent on these metabolic processes.
Article
Fisheries
Rafael Silva Marchao, Carlos Eduardo Copatti, Felipe Barbosa Ribeiro, Marcos Antonio Delmondes Bomfim, Maylanne Sousa de Lima, Vanessa Ferreira Batista, Aline da Silva Rocha, Gilmar Amaro Pereira, Thaisa Sales Costa, David Ramos da Rocha, Luiz Vitor Oliveira Vidal, Jose F. Bibiano Melo
Summary: This study aimed to estimate the digestible tryptophan requirement in diets for tambaqui in the fattening phase and found that the best dietary tryptophan concentration was between 3.42 and 3.73 g/kg, which resulted in optimal growth performance and whole-body deposition.
AQUACULTURE INTERNATIONAL
(2023)
Article
Fisheries
In-Seok Park, Seunghyung Lee, Gwang-Yeol Yoo
Summary: In this study, the optimum dietary protein level in hybrid pufferfish was evaluated. The fish that received 45% and 50% protein diets showed higher weight gain and growth rate. The protein content of 46.3% and 51.5% resulted in maximum growth of juvenile hybrid pufferfish.
AQUACULTURE REPORTS
(2022)
Article
Chemistry, Analytical
Yukuang Guo, Shaofei Ji, Wei Wang, Susan Wong, Chun-Wan Yen, Chloe Hu, Dennis H. Leung, Emile Plise, Shu Zhang, Chenghong Zhang, Uchenna A. Anene, Donglu Zhang, Christian N. Cunningham, S. Cyrus Khojasteh, Dian Su
Summary: Macrocyclic peptides (MCPs) are a promising class of drug modalities for targeting hard-to-drug targets, but their poor intestinal stability is a major obstacle for oral delivery. The study investigated the metabolic stability and biotransformation of MCPs in various matrices, revealing differences in metabolic pathways and identifying pancreatic enzymes as a primary barrier for oral delivery. Furthermore, lysosomal peptidase cathepsin B was found to be a major enzyme responsible for cleaving side-chain amide bonds in lysosomes, providing insights for lead candidate selection and optimization.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Lukasz Skalski, Sylwia Szelag-Pieniek, Mariola Post, Arkadiusz Parus, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Summary: Hepatic drug metabolizing enzymes (DMEs) play a crucial role in drug pharmacokinetics and can be affected by liver diseases. This study analyzed hepatitis C liver samples of different functional states and found that the protein abundances and mRNA levels of specific CYP and UGT enzymes were altered. The severity of the disease was associated with significant up-regulation or down-regulation of certain enzymes, indicating that hepatitis C virus infection impacts DMEs protein abundances in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Xin Zhao, Bingbing Zhang, Zhi Luo, Ye Yuan, Zhihui Zhao, Mengjun Liu
Summary: The composition and content of amino acids in 161 cultivars of jujube fruit were analyzed using HPLC. Of the 21 amino acids detected, 14 were found, including 8 predominant amino acids. Proline accounted for the highest proportion among the amino acids. Based on the analysis of amino acid ratios and comprehensive ranking, the top five cultivars were selected as 'Tengzhouchanghongzao', 'Xinzhengxiaoyuanzao', 'Hanguowudeng', 'Xuputiansuanzao', and 'Lichengxiaozao'.
Article
Agronomy
Andre Froes de Borja Reis, Luiz H. Moro Rosso, Dan Davidson, Peter Kovacs, Larry C. Purcell, Frederick E. Below, Shaun N. Casteel, Carrie Knott, Hans Kandel, Seth L. Naeve, Walter Carciochi, Willian J. Ross, Vitor Rampazzo Favoretto, Sotirios Archontoulis, Ignacio A. Ciampitti
Summary: This study utilized a meta-analytic model to quantify the effects of sulfur application at different growth stages on soybean yield and seed composition. Findings showed that applying sulfur at sowing can increase seed protein concentration, while sulfur amino acids concentration was not affected by the timing of fertilization. Additionally, soils with specific organic matter content displayed significant responses to sulfur application, while drought-stressed sites did not show significant changes in yield or seed composition due to sulfur fertilization.
EUROPEAN JOURNAL OF AGRONOMY
(2021)
Article
Nutrition & Dietetics
Mieke Cabout, Marjan Alssema, Giel Nijpels, Coen D. A. Stehouwer, Peter L. Zock, Ingeborg A. Brouwer, Amany K. Elshorbagy, Helga Refsum, Jacqueline M. Dekker
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Nutrition & Dietetics
Amany Elshorbagy, Fredrik Jerneren, Marianne Basta, Caroline Basta, Cheryl Turner, Maram Khaled, Helga Refsum
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Andrology
Adel El-shafaei, Rania Abdelmaksoud, Amany Elshorbagy, Noha Zahran, Rana Elabd
Article
Endocrinology & Metabolism
Anne J. Wanders, Marjan Alssema, Sabine E. M. De Hoon, Edith J. M. Feskens, Geertruida J. van Woudenbergh, Carla J. van der Kallen, Peter L. Zock, Helga Refsum, Christian A. Drevon, Amany Elshorbagy, Casper G. Schalkwijk, Coen D. A. Stehouwer, Jacqueline M. Dekker, Marleen M. J. van Greevenbroek
ANNALS OF NUTRITION AND METABOLISM
(2018)
Article
Nutrition & Dietetics
Amany K. Elshorbagy, Dorit Samocha-Bonet, Fredrik Jerneren, Cheryl Turner, Helga Refsum, Leonie K. Heilbronn
JOURNAL OF NUTRITION
(2018)
Article
Food Science & Technology
Marianne Basta, Abeer E. Dief, Doaa A. Ghareeb, Samar R. Saleh, Amany Elshorbagy, Eman El Eter
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Multidisciplinary Sciences
Passainte S. Hassaan, Abeer E. Dief, Teshreen M. Zeitoun, Azza M. Baraka, Robert M. J. Deacon, Amany Elshorbagy
Article
Endocrinology & Metabolism
Yi Su, Amany Elshorbagy, Cheryl Turner, Helga Refsum, Ruth Chan, Timothy Kwok
Article
Biochemistry & Molecular Biology
Amany K. Elshorbagy, Ian Graham, Helga Refsum
Article
Peripheral Vascular Disease
Hazem M. Warda, Amany K. Elshorbagy, Amira Habib, Ahmed Wagdi, Anastasia S. Mihailidou, Mamdouh Warda
JOURNAL OF CLINICAL HYPERTENSION
(2020)
Article
Nutrition & Dietetics
Nikhil Arora, Tor A. Strand, Ram K. Chandyo, Amany Elshorbagy, Laxman Shrestha, Per M. Ueland, Manjeswori Ulak, Catherine Schwinger
Article
Medicine, Research & Experimental
Emma Stolt, Thomas Olsen, Amany Elshorbagy, Viktor Kozich, Marleen van Greevenbroek, Bente Ovrebo, Magne Thoresen, Helga Refsum, Kjetil Retterstol, Kathrine J. Vinknes
Summary: This study will evaluate the effects of dietary sulfur amino acid (SAA) restriction on body weight and metabolic health through a double-blind 8-week dietary intervention involving 60 participants aged 18-45. Data will be analyzed using linear mixed model regression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hagar Elkafrawy, Radwa Mehanna, Fayrouz Ali, Ayman Barghash, Iman Dessouky, Fredrik Jerneren, Cheryl Turner, Helga Refsum, Amany Elshorbagy
Summary: Plasma cysteine fractions, specifically cystine and mixed disulfides, are positively associated with fat mass in healthy adults, while the major form bCys is not. Increasing cystine concentrations in vitro enhances adipogenesis and oxidative stress, suggesting a potential role for cystine in regulating human adipocyte turnover and metabolism.
Article
Nutrition & Dietetics
Amany K. Elshorbagy, Cheryl Turner, Nasser Bastani, Helga Refsum, Timothy Kwok
Summary: Serum sulfur amino acids (SAAs) and related amino acids (AAs) are strongly and independently associated with incident diabetes. This suggests that perturbations in the SAA metabolic pathway may be an early marker for diabetes risk.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Elena C. Tore, Amany K. Elshorbagy, Frans C. H. Bakers, Martijn C. G. J. Brouwers, Pieter C. Dagnelie, Simone J. P. M. Eussen, Jacobus F. A. Jansen, M. Eline Kooi, Yvo H. A. M. Kusters, Steven J. R. Meex, Thomas Olsen, Helga Refsum, Kjetil Retterstol, Casper G. Schalkwijk, Coen D. A. Stehouwer, Kathrine J. Vinknes, Marleen M. J. van Greevenbroek
Summary: This study examined the association between plasma sulfur amino acids and different fat depots. The results showed that methionine was associated with liver fat, while total cysteine was associated with overall obesity and central fat deposition.
EUROPEAN JOURNAL OF NUTRITION
(2023)