Mouse models and type 2 diabetes: translational opportunities

Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

(2011) R. D. Cox et al.   Disease Models & Mechanisms

Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes

(2011) Hua V. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Rosiglitazone Revisited

(2010) Steven E. Nissen et al.   ARCHIVES OF INTERNAL MEDICINE

Effect of Early Particulate Air Pollution Exposure on Obesity in Mice

(2010) Xiaohua Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes

(2010) Ebenezer A. Nyenwe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mapping quantitative traits and strategies to find quantitative trait genes

(2010) Jonathan Flint   METHODS

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

(2009) Kara K. Osbak et al.   HUMAN MUTATION

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

(2009) A. Ragvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the CHC22 Clathrin Heavy-Chain Isoform in Human Glucose Metabolism

(2009) S. Vassilopoulos et al.   SCIENCE

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

ENU Mutagenesis, a Way Forward to Understand Gene Function

(2008) Abraham Acevedo-Arozena et al.   Annual Review of Genomics and Human Genetics

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

(2008) M. Goldsworthy et al.   DIABETES

Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes

(2008) Martine Vaxillaire et al.   ENDOCRINE REVIEWS