Article
Parasitology
Judickaelle Irinantenaina, Gwenaelle Carn, Dina Ny Aina Liantsoa Randriamiarinjatovo, Aina Nirina Harimanana, Seheno Razanatsiorimalala, Nicolas Ralemary, Maurice Randriarison, Celestin Razafinjato, Raphael Hotahiene, Milijaona Randrianarivelojosia
Summary: A study conducted in Madagascar evaluated the efficacy and safety of artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria. The results showed that the combination of artesunate + amodiaquine and artemether + lumefantrine were effective and safe. The study suggests that these therapies can be used for treatment in health facilities, at the community level, and for mass drug administration campaigns. Rating: 8/10.
Article
Infectious Diseases
Sri Riyati Sugiarto, Madhu Page-Sharp, Jocelyn J. Drinkwater, Wendy A. Davis, Sam Salman, Timothy M. E. Davis
Summary: This study investigated the pharmacokinetic properties of artemether, lumefantrine, and their active metabolites in individuals with different body weights. The results indicate that dose modification of artemether-lumefantrine is not necessary for overweight and obese patients with malaria.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Medicine, General & Internal
Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Serge-Brice Assi, Jude D. Bigoga, Felix Koukouikila-Koussounda, Nsengi Y. Ntamabyaliro, Francine Ntoumi, Selidji T. Agnandji, Mirjam Groger, Jangsik Shin, Isabelle Borghini-Fuhrer, Sarah Arbe-Barnes, Stephen J. Allen, Peter G. Kremsner, Robert Miller, Stephan Duparc, Michael Ramharter
Summary: In a study conducted in Africa, pyronaridine-artesunate showed good tolerability and effectiveness in the treatment of acute uncomplicated malaria under conditions similar to everyday clinical practice, supporting its use as a useful addition in managing this condition.
Article
Medicine, General & Internal
Catherine Segbefia, Seth Kwabena Amponsah, Adwoa K. A. Afrane, Mame Yaa Nyarko, Yvonne Brew, Nihad Salifu, Samuel Yao Ahorhorlu, Abdul Malik Sulley, Lars Hviid, Michael Fokuo Ofori, George Obeng Adjei
Summary: In this study, interactions between hydroxyurea (HU) and antimalarials in sickle cell disease (SCD) were explored. The study found that parasite clearance and adverse event occurrence were similar in SCD children treated with artemether-lumefantrine (AL) regardless of HU status. However, distinct patterns of changes in laboratory indices suggest the potential need for larger, more focused studies in the future.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sikiru Olatunji Usman, Ibrahim Adekunle Oreagba, AbdulWasiu Busari, Akinwumi Akinyede, Ololade Adewumi, Michael Rotimi Kadri, Olayinka Hassan, Yinka Adeyemi Fashina, Esther Oluwatoyin Agbaje, Sulaimon Alani Akanmu
Summary: This study evaluated the interaction between artemether-lumefantrine (AL) and atazanavir-ritonavir (ATVr) in patients with HIV infection and malaria comorbidity, focusing on the cardiotoxicity and other adverse effects. The results showed that concomitant administration of AL and ATVr could potentially have cardiotoxic effects but did not lead to clinically significant renal, blood, or liver toxicities.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Infectious Diseases
Andre Silva-Pinto, Joao Domingos, Margarida Cardoso, Ana Reis, Ernest Diez Benavente, Joao Paulo Caldas, Claudia Conceicao, Cristina Toscano, Teresa Baptista-Fernandes, Taane G. Clark, Kamal Mansinho, Susana Campino, Fatima Nogueira
Summary: The failure of artemisinin combination therapy (ACT) in malaria patients may be due to parasite resistance. There is a need for close monitoring of signs of unsatisfactory anti-malarial efficacy among ACT treated patients, and the possible implication of other genes or mutations in parasite response to ACTs.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Dominic Mosha, Mwaka A. Kakolwa, Muhidin K. Mahende, Honorati Masanja, Salim Abdulla, Chris Drakeley, Roland Gosling, Joyce Wamoyi
Summary: The study aimed to explore the acceptance, reliability, and perceived effectiveness of the single-low dose primaquine and the monitoring pharmacovigilance tool PROMPT. The results showed general acceptance and perceived effectiveness of primaquine, with safety concerns and challenges in administering the drug to children. Further validation involving the National Malaria Control Programme is essential for facilitating primaquine adoption in national policies.
Article
Infectious Diseases
Peter Thelma Ngwa Niba, Akindeh Mbuh Nji, Innocent Mbulli Ali, Lawrence Fonyonga Akam, Cedric Hermann Dongmo, Jean Paul Kengne Chedjou, Calvino Tah Fomboh, William Dorian Nana, Ornella Laetitia Ayem Oben, Abdel Aziz Selly-Ngaloumo, Marcel N. Moyeh, Jude Achidi Ngu, Ambassa Jean Ludovic, Pierre Martiniel Aboh, Marie Carine Enyegue Ambani, Pierrette Albertine Mbarga Omgba, Grace Bissohong Kotcholi, Linus Moye Adzemye, Danielle Regine Abenkou Nna, Adele Douanla, Ze Ango, Marie Sophie Ewane, Joel Tewara Ticha, Fritz Mbuh Tatah, Golwa Dinza, Valentine Nchafor Ndikum, Dorothy A. Fosah, Jude D. Bigoga, Michael Alifrangis, Wilfred F. Mbacham
Summary: This study evaluated the effectiveness and safety of AS-AQ and AL for home-based treatment of uncomplicated P. falciparum malaria in Yaounde, Cameroon. The results showed that both AS-AQ and AL were effective and safe for the management of malaria in a home setting.
BMC INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Hamma Maiga, Anastasia Grivoyannis, Issaka Sagara, Karim Traore, Oumar B. Traore, Youssouf Tolo, Aliou Traore, Amadou Bamadio, Zoumana I. Traore, Kassim Sanogo, Ogobara K. Doumbo, Christopher V. Plowe, Abdoulaye A. Djimde
Summary: The study evaluated the efficacy of artemether-lumefantrine in treating uncomplicated Plasmodium falciparum malaria in Mali. Results showed a high ACPR rate and a decrease in pfcrt 76T and pfmdr1 86Y genotypes associated with drug resistance. The study suggests a potential reintroduction of chloroquine or amodiaquine for future malaria treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Xiaodan Zhang, Qingqing Li, Quan Zhou, Yunxuan Li, Junwei Li, Lehao Jin, Sen Li, Jianping Cai, Gaozhi Chen, Guoxin Hu, Jianchang Qian
Summary: This study evaluated the impact of CYP3A4 gene polymorphism on the metabolism of artemether-lumefantrine and found significant differences in the clearance rate of different genotypes. These findings enhance our understanding of drug metabolism and provide important insights for guiding treatment strategies.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Infectious Diseases
Kale Gubae, Hussein Mohammed, Heven Sime, Henok Hailgiorgis, Anteneh Kassahun Mare, Bokretsion Gidey, Mebrahtom Haile, Gudissa Assefa, Worku Bekele, Geremew Tasew, Solomon Mequanente Abay, Ashenafi Assefa
Summary: This study aimed to assess the therapeutic efficacy of AL in the treatment of uncomplicated P. falciparum infection. The results showed that AL demonstrated high therapeutic efficacy and good safety profile, suggesting its continuation as the first-line drug for the treatment of uncomplicated P. falciparum malaria in Ethiopia.
Article
Microbiology
Nelli Westercamp, Mary Owidhi, Kephas Otieno, Winnie Chebore, Ann M. Buff, Meghna Desai, Simon Kariuki, Aaron M. Samuels
Summary: The study compared the efficacy of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in the treatment of uncomplicated malaria. The results showed that both AL and DP were efficacious and well tolerated, but the efficacy of AL appeared to be waning.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Tijs K. Tournoy, Anna Rosanas-Urgell, Marjan Van Esbroeck, Emmanuel Bottieau, Ralph Huits
Summary: We reported a case of Plasmodium malariae malaria in a traveler who returned from the Democratic Republic of Congo to Belgium. This case occurred despite the individual receiving successful treatment for Plasmodium falciparum three weeks earlier and not being re-exposed to the infection in an endemic area. We discussed possible explanations for this unusual observation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Tijs K. Tournoy, Anna Rosanas-Urgell, Marjan Van Esbroeck, Emmanuel Bottieau, Ralph Huits
Summary: A traveler was diagnosed with Plasmodium malariae malaria despite having received successful treatment for Plasmodium falciparum three weeks earlier and without re-exposure in an endemic area. Possible explanations for this uncommon observation were discussed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Chris Ebong, Asadu Sserwanga, Jane Frances Namuganga, James Kapisi, Arthur Mpimbaza, Samuel Gonahasa, Victor Asua, Sam Gudoi, Ruth Kigozi, James Tibenderana, John Bosco Bwanika, Agaba Bosco, Denis Rubahika, Daniel Kyabayinze, Jimmy Opigo, Damian Rutazana, Gloria Sebikaari, Kassahun Belay, Mame Niang, Eric S. Halsey, Leah F. Moriarty, Naomi W. Lucchi, Samaly S. Svigel Souza, Sam L. Nsobya, Moses R. Kamya, Adoke Yeka
Summary: In Uganda, DP remains highly effective and safe for the treatment of uncomplicated malaria, while monitoring of AL efficacy shows recurrent infections.
Article
Pediatrics
K. A. Oshikoya, H. Sammons, K. Smith, I. Choonara
ARCHIVES OF DISEASE IN CHILDHOOD
(2015)
Article
Anthropology
Idowu O. Senbanjo, Kazeem A. Oshikoya, Olanike A. Olutekunbi, Olisamedua F. Njokanma
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
I. O. Senbanjo, K. A. Oshikoya
CARDIOVASCULAR JOURNAL OF AFRICA
(2012)
Article
Pediatrics
Idowu Odunayo Senbanjo, Kazeem Adeola Oshikoya, Olisamedua Fidelis Njokanma
WORLD JOURNAL OF PEDIATRICS
(2014)
Article
Infectious Diseases
Idowu O. Senbanjo, Kazeem A. Oshikoya, Olisamedua F. Njokanma
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2014)
Meeting Abstract
Immunology
K. Oshikoya, S. Lawal, I Oreagba, C. Ezeaka, E. Temiye, T. Adeyemo
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2012)
Article
Integrative & Complementary Medicine
I. O. Ishola, I. A. Oreagba, A. A. Adeneye, C. Adirije, K. A. Oshikoya, O. O. Ogunleye
JOURNAL OF HERBAL MEDICINE
(2014)
Article
Health Care Sciences & Services
Kazeem A. Oshikoya, Ibrahim A. Oreagba, Olayinka O. Ogunleye, Saheed Lawal, Idowu O. Senbanjo
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2013)
Article
Integrative & Complementary Medicine
K. A. Oshikoya, I. A. Oreagba, O. O. Ogunleye, M. Hassan, I. O. Senbanjo
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2014)
Article
Obstetrics & Gynecology
Idowu O. Senbanjo, Kazeem A. Oshikoya, Okeoghene A. Ogbera, Kikelomo O. Wright, Alexandra L. Anga
INTERNATIONAL BREASTFEEDING JOURNAL
(2014)
Article
Pediatrics
K. A. Oshikoya, B. Edun, I. A. Oreagba
SOUTH AFRICAN JOURNAL OF CHILD HEALTH
(2015)
Article
Public, Environmental & Occupational Health
Kazeem Adeola Oshikoya, Ibrahim Oreagba, Olayinka Adeyemi
PAN AFRICAN MEDICAL JOURNAL
(2011)
Article
Infectious Diseases
Kazeem A. Oshikoya, Ibrahim A. Oreagba, Saheed Lawal, Olufunsho Awodele, Olayinka O. Ogunleye, Idowu O. Senbanjo, Sunday O. Olayemi, Veronica C. Ezeaka, Edamisan O. Temiye, Titilope A. Adeyemo, Oluranti Opanuga, Olufunmilayo A. Lesi, Sulaimon A. Akanmu
HIV AIDS-RESEARCH AND PALLIATIVE CARE
(2014)
Article
Pharmacology & Pharmacy
Kazeem A. Oshikoya, Ken Smith
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS
(2013)