Article
Biochemical Research Methods
Aleena Das, Welka Sahu, Deepak Kumar Ojha, K. Sony Reddy, Mrutyunjay Suar
Summary: An untargeted metabolomics approach was used to identify the changes in metabolic pathways and metabolites in the serum of mice with different pathological stages of malaria. The study provides insights into the host biology during malaria and could be helpful for the selection of animal models for evaluating diagnostic and therapeutic interventions against malaria.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Immunology
Priyanka Barua, Michael F. Duffy, Laurens Manning, Moses Laman, Timothy M. E. Davis, Ivo Mueller, Ali Haghiri, Julie A. Simpson, James G. Beeson, Stephen J. Rogerson
Summary: In children from Papua New Guinea with severe or uncomplicated malaria, antibody recognition of homologous but not heterologous isolates was boosted in convalescence and showed variations with ABO blood group. Patterns of var gene transcription distinguished severe from uncomplicated malaria. ABO blood group may influence antibody acquisition to VSAs and susceptibility to severe malaria.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Leen Vandermosten, Fran Prenen, Balotin Fogang, Pauline Dagneau de Richecour, Sofie Knoops, Christiane Josiane Donkeu, Cathy Doric Piemba Nguefack, Jean-Voisin Taguebue, Paul Koki Ndombo, Bart Ghesquiere, Lawrence Ayong, Philippe E. Van den Steen
Summary: This study investigated the response of adrenal hormones in children with different types of malaria in Cameroon. The study found that patients with clinical malaria had increased cortisol levels but decreased sensitivity to adrenal hormones, which may contribute to the severity of the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
James A. Watson, Sophie Uyoga, Perpetual Wanjiku, Johnstone Makale, Gideon M. Nyutu, Neema Mturi, Elizabeth C. George, Charles J. Woodrow, Nicholas P. J. Day, Philip Bejon, Robert O. Opoka, Arjen M. Dondorp, Chandy C. John, Kathryn Maitland, Thomas N. Williams, Nicholas J. White
Summary: Severe malaria caused by Plasmodium falciparum is difficult to accurately diagnose in children in high-transmission settings. A combination of platelet count and plasma PfHRP2 concentration can be used to identify severe falciparum malaria in severely ill patients. About one-third of children enrolled in clinical studies of severe malaria in high-transmission settings in Africa had other causes of their severe illness.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Infectious Diseases
Judicael Boris Lendongo Wombo, Euloge Ibinga, Sandrine Lydie Oyegue-Liabagui, Romeo Karl Imboumy Limoukou, Alain Prince Okouga, Franck Mounioko, Sydney Maghendji-Nzondo, Jean Bernard Lekana-Douki, Edgard Brice Ngoungou
Summary: This study describes the epidemiological aspects of severe malaria in rural, semi-rural, and urban areas of southeast Gabon. The study found that the epidemiological characteristics of severe malaria were similar in the three settings, but more severe in urban areas. Children under 5 years of age are the most vulnerable age group.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Katherine O'Flaherty, Jo-Anne Chan, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Nicholas P. Day, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Francois Nosten, James G. Beeson, Julie A. Simpson, Nicholas J. White, Freya J. Fowkes
Summary: The study found that Pfs230 and Pfs48/45 antibodies are associated with patent gametocytemia and increasing gametocyte density across multiple malaria endemic settings, including regions with emerging artemisinin-resistant P. falciparum.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Hematology
Kathryn Maitland, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Yami Chimalizeni, Florence Alaroker, Sophie Uyoga, Dorothy Kyeyune-Byabazaire, Bridon M'baya, Imelda Bates, Thomas N. Williams, Deogratias Munube, Dora Mbanya, Elizabeth M. Molyneux, Annabelle South, A. Sarah Walker, Diana M. Gibb, Elizabeth C. George
Summary: The TRACT trial found that conservative management of uncomplicated severe anaemia was safe, and that transfusion volume had opposing effects on mortality depending on fever status. A stakeholder meeting in 2020 reviewed the results and additional analyses, leading to the development of a transfusion management algorithm for safe implementation.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Immunology
Meghan E. Whalen, Richard Kajubi, Justin Goodwin, Francis Orukan, McKenzie Colt, Liusheng Huang, Kacey Richards, Kaicheng Wang, Fangyong Li, Norah Mwebaza, Francesca T. Aweeka, Sunil Parikh
Summary: Extending the duration of AL can increase drug exposure in young children, but it does not significantly reduce the risk of recurrent parasitemia in a high-transmission setting. Clinically, day 7 lumefantrine levels can be used as an indicator to predict the risk of recurrent parasitemia.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Thandile Nkosi-Gondwe, Job Calis, Michael Boele van Hensbroek, Imelda Bates, Bjorn Blomberg, Kamija S. Phiri
Summary: The study found that severely anaemic children with moderate to severe acute malnutrition had a twofold higher risk of death compared to children with severe anaemia alone. Additionally, children with moderate to severe malnutrition were more likely to have malaria infections. However, there was no statistically significant difference between the two groups in terms of hospitalizations and recurrence of severe anaemia.
Article
Infectious Diseases
Selidji Agnandji, Mario Recker, Benjamin Mordmueller, Stephan Gloeckner, Akim A. Adegnika, Bertrand Lell, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Kwaku P. Asante, Tsiri Agbenyega, Daniel Ansong, Eusebio Macete, Pedro Aide, Hermann Sorgho, Halidou Tinto, Neema Mturi, John P. A. Lusingu, Samwel Gesase, Irving Hoffman, Nahya Salim Masoud, Charles R. Newton, Kalifa Bojang, Gerard Krause, Peter Gottfried Kremsner
Summary: Malaria remains a major cause of hospitalization in children in sub-Saharan Africa. Rapid risk stratification upon admission is crucial for optimal medical care and improved prognosis. While coma, deep breathing, and to some extent severe anemia are established predictors of malaria-related death, the significance of assessing prostration for risk stratification is not yet certain.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Hematology
Peter Olupot-Olupot, Roisin Connon, Sarah Kiguli, Robert O. Opoka, Florence Alaroker, Sophie Uyoga, Margret Nakuya, William Okiror, Julius Nteziyaremye, Tonny Ssenyondo, Eva Nabawanuka, Juliana Kayaga, Cynthia Williams Mukisa, Denis Amorut, Rita Muhindo, Gary Frost, Kevin Walsh, Alexander W. Macharia, Diana M. Gibb, A. Sarah Walker, Elizabeth C. George, Kathryn Maitland, Thomas N. Williams
Summary: Sickle cell anemia is common in sub-Saharan Africa, and a trial in Uganda and Malawi found that 12% of children had known sickle cell anemia and 17% had unknown sickle cell anemia. Children with sickle cell anemia showed better outcomes in various indicators.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Catherine Segbefia, Seth Kwabena Amponsah, Adwoa K. A. Afrane, Mame Yaa Nyarko, Yvonne Brew, Nihad Salifu, Samuel Yao Ahorhorlu, Abdul Malik Sulley, Lars Hviid, Michael Fokuo Ofori, George Obeng Adjei
Summary: In this study, interactions between hydroxyurea (HU) and antimalarials in sickle cell disease (SCD) were explored. The study found that parasite clearance and adverse event occurrence were similar in SCD children treated with artemether-lumefantrine (AL) regardless of HU status. However, distinct patterns of changes in laboratory indices suggest the potential need for larger, more focused studies in the future.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Nina C. Brunner, Jean-Claude Kalenga, Babatunde K. Akano, Kazeem Ayodeji, Charles Okon, Ocheche Yusuf, Proscovia Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro, Giulia Delvento, Tristan T. Lee, Mark J. Lambiris, Marek Kwiatkowski, Nadja Cereghetti, Theodoor Visser, Harriet G. Napier, Justin M. Cohen, Valentina Buj, Christian Burri, Christian Lengeler
Summary: This study examined the effectiveness of pre-referral rectal artesunate treatment implemented in the Democratic Republic of the Congo (DRC), Nigeria, and Uganda. In Nigeria, the case fatality rate was higher post-roll-out of RAS, while it remained stable in DRC and Uganda. Only in Uganda, children who received RAS were less likely to be dead or sick at follow-up.
Article
Medicine, General & Internal
Samuel Odarkwei Blankson, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Tornyigah, Rafiou Adamou, Azizath Moussiliou, Caroline Padounou, Annick Amoussou, Benedicta Ayiedu Mensah, Maroufou J. J. Alao, Gordon Awandare, Nicaise Tuikue Ndam, Christian Roussilhon, Rachida Tahar
Summary: This study evaluated the levels of plasma soluble neopterin in severe malaria patients and assessed its prognostic accuracy. The results showed that neopterin levels were higher in patients with severe malarial anemia and in patients who died from the disease. Plasma neopterin levels may serve as a potential biomarker for predicting fatality in severe falciparum malaria patients.
Article
Medicine, General & Internal
Memoona Khan, Haider Nisar, Nuzhat Mushahid
Summary: The study aimed to compare the clinical and laboratory profiles of severe and uncomplicated malaria in Khuzdar, Southern Balochistan, finding a significant association between severe malaria and various symptoms and lab parameters. Furthermore, it was discovered that children with malaria had a significantly higher frequency of complications compared to adult patients. Certain clinical and lab parameters can be used to predict prognosis in malaria, helping to avoid adverse outcomes.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Infectious Diseases
Clarisse Njua-Yafi, Eric A. Achidi, Judith K. Anchang-Kimbi, Tobias O. Apinjoh, Regina N. Mugri, Hanesh F. Chi, Rolland B. Tata, Charles Njumkeng, Emmanuel N. Nkock, Theresa Nkuo-Akenji
Article
Infectious Diseases
Jodie Dionne-Odom, Andrew O. Westfall, Tobias O. Apinjoh, Judith Anchang-Kimbi, Eric A. Achidi, Alan T. N. Tita
Article
Multidisciplinary Sciences
Gavin G. Rutledge, Ulrike Bohme, Mandy Sanders, Adam J. Rrid, James A. Cotton, Oumou Maiga-Ascofare, Abdoulaye A. Djimde, Tobias O. Apinjoh, Lucas Amenga-Etego, Magnus Manske, John W. Barnwell, Francois Renaud, Benjamin Ollomo, Franck Prugnolle, Nicholas M. Anstey, Sarah Auburn, Ric N. Price, James S. McCarthy, Dominic P. Kwiatkowski, Chris I. Newbold, Matthew Berriman, Thomas D. Otto
Article
Multidisciplinary Sciences
Ellen M. Leffler, Gavin Band, George B. J. Busby, Katja Kivinen, Quang Si Le, Geraldine M. Clarke, Kalifa A. Bojang, David J. Conway, Muminatou Jallow, Fatoumatta Sisay-Joof, Edith C. Bougouma, Valentina D. Mangano, David Modiano, Sodiomon B. Sirima, Eric Achidi, Tobias O. Apinjoh, Kevin Marsh, Carolyne M. Ndila, Norbert Peshu, Thomas N. Williams, Chris Drakeley, Alphaxard Manjurano, Hugh Reyburn, Eleanor Riley, David Kachala, Malcolm Molyneux, Vysaul Nyirongo, Terrie Taylor, Nicole Thornton, Louise Tilley, Shane Grimsley, Eleanor Drury, Jim Stalker, Victoria Cornelius, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Kirk A. Rockett, Chris C. A. Spencer, Dominic P. Kwiatkowski
Article
Biology
Geraldine M. Clarke, Kirk Rockett, Katja Kivinen, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Muminatou Jallow, David J. Conway, Kalifa A. Bojang, Margaret Pinder, Stanley Usen, Fatoumatta Sisay-Joof, Giorgio Sirugo, Ousmane Toure, Mahamadou A. Thera, Salimata Konate, Sibiry Sissoko, Amadou Niangaly, Belco Poudiougou, Valentina D. Mangano, Edith C. Bougouma, Sodiomon B. Sirima, David Modioano, Lucas N. Amenga-Etego, Anita Ghansah, Kwadwo A. Koram, Michael D. Wilson, Anthony Enimil, Jennifer Evans, Olukemi K. Amodu, Subulade Olaniyan, Tobias Apinjoh, Regina Mugri, Andre Ndi, Carolyne M. Ndila, Sophie Uyoga, Alexander Macharia, Norbert Peshu, Thomas N. Williams, Alphaxard Manjurano, Nuno Sepulveda, Taane G. Clark, Eleanor Riley, Chris Drakeley, Hugh Reyburn, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Sarah J. Dunstan, Nguyen Hoan Phu, Nguyen Ngoc Quyen, Cao Quang Thai, Tran Tinh Hien, Laurens Manning, Moses Laman, Peter Siba, Harin Karunajeewa, Steve Allen, Angela Allen, Timothy M. E. Davis, Pascal Michon, Ivo Mueller, SIle F. Molloy, Susan Campino, Angeliki Kerasidou, Victoria J. Cornelius, Lee Hart, Shivang S. Shah, Gavin Band, Chris C. A. Spencer, Tsiri Agbenyega, Eric Achidi, Ogobara K. Doumbo, Jeremy Farrar, Kevin Marsh, Terrie Taylor, Dominic P. Kwaitkowski
Article
Infectious Diseases
Tobias O. Apinjoh, Regina N. Mugri, Olivo Miotto, Hanesh F. Chi, Rolland B. Tata, Judith K. Anchang-Kimbi, Eleanor M. Fon, Delphine A. Tangoh, Robert V. Nyingchu, Christopher Jacob, Roberto Amato, Abdoulaye Djimde, Dominic Kwiatkowski, Eric A. Achidi, Alfred Amambua-Ngwa
INFECTIOUS DISEASES OF POVERTY
(2017)
Article
Hematology
Carolyne M. Ndila, Sophie Uyoga, Alexander W. Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O. Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepulveda, Taane G. Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret Mackinnon, Kathryn Maitland, Dominic P. Kwiatkowski, Kirk A. Rockett, Thomas N. Williams
LANCET HAEMATOLOGY
(2018)
Review
Infectious Diseases
Tobias O. Apinjoh, Amed Ouattara, Vincent P. K. Titanji, Abdoulaye Djimde, Alfred Amambua-Ngwa
Article
Public, Environmental & Occupational Health
Charles Njumkeng, Tobias O. Apinjoh, Judith K. Anchang-Kimbi, Elvis T. Amin, Elvis A. Tanue, Clarisse Njua-Yafi, Eric A. Achidi
Article
Multidisciplinary Sciences
Alfred Amambua-Ngwa, Lucas Amenga-Etego, Edwin Kamau, Roberto Amato, Anita Ghansah, Lemu Golassa, Milijaona Randrianarivelojosia, Deus Ishengoma, Tobias Apinjoh, Oumou Maiga-Ascofare, Ben Andagalu, William Yavo, Marielle Bouyou-Akotet, Oyebola Kolapo, Karim Mane, Archibald Worwui, David Jeffries, Vikki Simpson, Umberto D'Alessandro, Dominic Kwiatkowski, Abdoulaye A. Djimde
Article
Infectious Diseases
Judith K. Anchang-Kimbi, Laken N. Kalaji, Harry F. Mbacham, Godlove B. Wepnje, Tobias O. Apinjoh, Irene U. Sumbele, Jodie Dionne-Odom, Alan T. N. Tita, Eric A. Achidi
Article
Multidisciplinary Sciences
Gavin Band, Quang Si Le, Geraldine M. Clarke, Katja Kivinen, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Ellen M. Leffler, Muminatou Jallow, David J. Conway, Fatoumatta Sisay-Joof, Giorgio Sirugo, Umberto d'Alessandro, Ousmane B. Toure, Mahamadou A. Thera, Salimata Konate, Sibiri Sissoko, Valentina D. Mangano, Edith C. Bougouma, Sodiomon B. Sirima, Lucas N. Amenga-Etego, Anita K. Ghansah, Abraham V. O. Hodgson, Michael D. Wilson, Anthony Enimil, Daniel Ansong, Jennifer Evans, Subulade A. Ademola, Tobias O. Apinjoh, Carolyne M. Ndila, Alphaxard Manjurano, Chris Drakeley, Hugh Reyburn, Nguyen Hoan Phu, Nguyen Thi Ngoc Quyen, Cao Quang Thai, Tran Tinh Hien, Yik Ying Teo, Laurens Manning, Moses Laman, Pascal Michon, Harin Karunajeewa, Peter Siba, Steve Allen, Angela Allen, Melanie Bahlo, Timothy M. E. Davis, Victoria Simpson, Jennifer Shelton, Chris C. A. Spencer, George B. J. Busby, Angeliki Kerasidou, Eleanor Drury, Jim Stalker, Alexander Dilthey, Alexander J. Mentzer, Gil McVean, Kalifa A. Bojang, Ogobara Doumbo, David Modiano, Kwadwo A. Koram, Tsiri Agbenyega, Olukemi K. Amodu, Eric Achidi, Thomas N. Williams, Kevin Marsh, Eleanor M. Riley, Malcolm Molyneux, Terrie Taylor, Sarah J. Dunstan, Jeremy Farrar, Ivo Mueller, Kirk A. Rockett, Dominic P. Kwiatkowski
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Kevin K. Esoh, Tobias O. Apinjoh, Steven G. Nyanjom, Ambroise Wonkam, Emile R. Chimusa, Lucas Amenga-Etego, Alfred Amambua-Ngwa, Eric A. Achidi
Summary: Genetic association studies rely on defining underlying populations, which can be confounded by population structure. A study in Cameroon revealed fine-scale genetic structure and longstanding sympatric differentiation among ethnic groups. Selection signatures in HLA and HBB genes confirmed natural selection and balancing selection in African populations, shaping genomes of Cameroonian populations.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
O. Ajibola, M. F. Diop, A. Ghansah, L. Amenga-Etego, L. Golassa, T. Apinjoh, M. Randrianarivelojosia, O. Maiga-Ascofare, W. Yavo, M. Bouyou-Akotet, K. M. Oyebola, B. Andagalu, U. D'Alessandro, D. Ishengoma, A. A. Djimde, E. Kamau, A. Amambua-Ngwa
Summary: The study identified balancing selection signatures for most antigens across populations, except for phistb which showed lower diversity. This suggests that immune selection may be influencing these antigens, with phistb potentially being a target for immune recognition.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Tobias O. Apinjoh, Veronica N. Ntasin, Phil Collins C. Tataw, Vincent N. Ntui, Dieudonne L. Njimoh, Fidelis Cho-Ngwa, Eric A. Achidi
Summary: This study compared conventional and non-invasive diagnostic tools for detecting Plasmodium falciparum. The results showed that rapid testing on saliva had higher parasite detection rates and sensitivity compared to urine, suggesting it as a practical adjunct or alternative for routine malaria diagnosis.
INFECTIOUS DISEASES OF POVERTY
(2021)