Article
Microbiology
Stefano R. Rosillo, Pedro Rafael Dimbu, Ana Luisa M. Candido, Je-Hoon Michael Oh, Carolina Miguel Ferreira, Benjamin Nieto Andrade, Sarah Labuda, Roberta Horth, Julia Kelley, Joana F. M. Morais, Filomeno Fortes, Jose Franco Martins, Eldin Talundzic, Mateusz M. Plucinski
Summary: We sequenced the pfdhfr and pfdhps genes in samples of pregnant women in Angola using SP for malaria prevention. We found high proportions of mutations in these genes associated with SP resistance in all provinces. Some low-frequency mutations were also observed. These findings suggest the presence of SP resistance in Angola.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Parasitology
Rini Chaturvedi, Jyoti Chhibber-Goel, Ishika Verma, Sreehari Gopinathan, Suhel Parvez, Amit Sharma
Summary: The study collected data on sulfadoxine-pyrimethamine resistance mutations from 2005 to 2019, finding that pyrimethamine-resistant double mutations are widespread in Asia, the Middle East, and the Indian sub-continent, while triple mutations prevail in Africa and South America. Single point mutations in sulfadoxine resistance dominate globally.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Microbiology
Carole Else Eboumbou Moukoko, Loick Pradel Kojom Foko, Angele Ayina, Bernard Tornyigah, Annie Rachel Epote, Ida Calixte Penda, Patricia Epee Eboumbou, Serge Bruno Ebong, Gaetan Texier, Sandrine Eveline Nsango, Lawrence Ayong, Nicaise Tuikue Ndam, Albert Same Ekobo
Summary: This study aimed to assess the impact of sulfadoxine and pyrimethamine (SP) resistance on intermittent preventive treatment in pregnancy (IPTp-SP) in Douala, Cameroon. The overall IPTp-SP coverage was low, and most pregnant women had submicroscopic malaria infections. Optimal doses of IPTp-SP reduced infection rates in newborns and women, but had no impact on newborn bodyweight. Multiple SP-resistant P. falciparum parasites were prevalent in Douala.
Article
Microbiology
Wassihun Wedajo Aragaw, Dereje A. Negatu, Christopher J. Bungard, Veronique A. Dartois, Abdellatif El Marrouni, Elliott B. Nickbarg, David B. Olsen, Ralf Warrass, Thomas Dick
Summary: This study provides evidence that M. abscessus DHFR is a promising target for drug discovery, and PQD-1 serves as a chemical starting point for targeting this pathway. Furthermore, PQD-1 exhibits synergy with other drugs, offering the opportunity to develop drug combinations against M. abscessus.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Haffsatou Sawadogo, Issiaka Soulama, Adama Zida, Cheikna Zongo, Patindoilba Marcel Sawadogo, Kiswendsida Thierry Guiguemde, Seni Nikiema, Salimata Emilie Badoum, Salam Sawadogo, Aicha Tou, Salif Sombie, Chanolle Tchekounou, Sindie Samuel Serme, Rasmata Ouedraogo-Traore, Tinga Robert Guiguemde, Aly Savadogo
Summary: This study investigated the genetic diversity of Plasmodium falciparum and the mutation prevalence in the dhfr and dhps genes in postpartum infected placentas. The results showed a high genetic diversity in msp1 and msp2, suggesting that mutant genotypes in dhfr and dhps could be potential early warning factors for the increase in sulfadoxine-pyrimethamine resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Enesia Banda Chaponda, Sungano Mharakurwa, Charles Michelo, Jane Bruce, Daniel Chandramoha, R. Matthew Chico
Summary: In Nchelenge, Zambia, a study on pregnant women receiving IPTp-SP showed high rates of parasitological and chemoprophylactic failure of SP, as well as a concerning prevalence of resistance markers. Alternative therapies are urgently needed to protect pregnant women against malaria infection.
Article
Biochemistry & Molecular Biology
Abhishek Saini, Amit Kumar, Kailash Jangid, Vinod Kumar, Vikas Jaitak
Summary: Bacterial infections are increasing and antimicrobial resistance (AMR) is worsening, necessitating research into alternative therapeutic agents. This study focused on evaluating terpenoids using computational methods for their affinity towards the enzymes involved in bacterial DNA synthesis proteins. Five compounds were identified as having higher affinity towards the target enzymes, and they also showed activity against resistant bacteria. The docking study was further validated using binding free energy calculations and molecular dynamics simulations.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Parasitology
Pauline Winnie Orondo, Steven G. Nyanjom, Harrysone Atieli, John Githure, Benyl M. Ondeto, Kevin O. Ochwedo, Collince J. Omondi, James W. Kazura, Ming-Chieh Lee, Guofa Zhou, Daibin Zhong, Andrew K. Githeko, Guiyun Yan
Summary: A study conducted in western Kenya revealed increased phenotypic resistance of Anopheles arabiensis in irrigated areas, potentially linked to intensive pesticide use for crop protection in the region. However, the susceptibility of malaria vectors to organophosphates and PBO synergists in pyrethroids offers a promising future for IRS and insecticide-treated net-based vector control interventions.
PARASITES & VECTORS
(2021)
Article
Immunology
Sequoia Leuba, Daniel Westreich, Carl L. Bose, Kimberly A. Powers, Andy Olshan, Steve M. Taylor, Antoinette Tshefu, Adrien Lokangaka, Waldemar A. Carlo, Elwyn Chomba, Edward A. Liechty, Sherri L. Bucher, Fabian Esamai, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Janet Moore, Tracy Nolen, Jennifer Hemingway-Foday, Elizabeth M. McClure, Marion Koso-Thomas, Richard J. Derman, Matthew Hoffman, Melissa Bauserman
Summary: The prevalence of first-trimester malaria varies by study site in sub-Saharan Africa, and no consistent predictors have been identified, suggesting that routine parasite screening in early pregnancy may be needed to mitigate first-trimester malaria.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Aaron M. Samuels, Oliver Towett, Brian Seda, Ryan E. Wiegand, Kephas Otieno, Miriam Chomba, Naomi Lucchi, Dragan Ljolje, Kammerle Schneider, Patrick Gt, Titus K. Kwambai, Laurence Slutsker, Feiko O. Ter Kuile, Simon K. Kariuki
Summary: Screening pregnant women for malaria using new point-of-care tests showed moderate improvement in detecting low-density infections compared to conventional rapid diagnostic tests (cRDTs).
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Hong Quan, Peng Yu, Kokouvi Kassegne, Hai-Mo Shen, Shen-Bo Chen, Jun-Hu Chen
Summary: In 2013, an epidemic of falciparum malaria involving over 820 persons unexpectedly broke out in Shanglin County, Guangxi Zhuang Autonomous Region, China, after a large number of migrant workers returned from Ghana, where they worked as gold miners. The investigation found that the samples collected from Chinese migrant workers from Ghana showed prevalent but relatively low resistance to sulfadoxine-pyrimethamine (SP). It is necessary to strengthen reasonable drug use and management and continue screening for SP resistance.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Seda Yerlikaya, Ewurama D. A. Owusu, Augustina Frimpong, Robert Kirk DeLisle, Xavier C. Ding
Summary: This study identified two novel malaria diagnostic biomarkers, glyceraldehyde 3-phosphate dehydrogenase and dihydrofolate reductase-thymidylate synthase, through a systematic review and in silico analysis. These candidates have favorable diagnostic features and partially de-risked product development prospects, paving the way for next-generation malaria rapid diagnostic tests.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Joshua A. Mutanyi, Daniel O. Onguru, Sidney O. Ogolla, Lawrence B. Adipo
Summary: This study found a high level of optimal uptake of IPTp-SP in the Sabatia Sub County of Kenya, with factors such as timing and frequency of antenatal care visits, women's understanding of the benefits and dosage of the service, influencing the likelihood of pregnant women receiving optimal care. Efforts should be directed towards early and more frequent ANC visits, along with intensive and targeted health education to improve IPTp-SP uptake.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Parasitology
Amine M. Mustapha, Susan Musembi, Anthony K. Nyamache, Maxwell G. Machani, Jackline Kosgei, Lucy Wamuyu, Eric Ochomo, Neil F. Lobo
Summary: This study investigated the species compositions and bionomic traits of secondary malaria vectors in three high transmission sites in Kisumu County, western Kenya. The results show that these secondary vectors, primarily caught outdoors, have higher proportions of Plasmodium-infected individuals and exhibit susceptibility to insecticides, indicating their potential significant contribution to malaria transmission. Further studies on morphological and molecular identification of these vectors are needed for better understanding and monitoring of their roles in malaria transmission and development of insecticide resistance.
PARASITES & VECTORS
(2021)
Article
Immunology
Ben Andagalu, Oliver J. Watson, Irene Onyango, Benjamin Opot, Raphael Okoth, Gladys Chemwor, Peter Sifuna, Dennis Juma, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Jackline Wafubwa, Santos Yalwala, David Abuom, Bernhards Ogutu, Jessica Cowden, Hoseah M. Akala, Edwin Kamau
Summary: This study investigated the transmission dynamics in an asymptomatic population in a high-malaria-burden region in Kenya and identified primary school children as the most important infectious reservoir for malaria transmission. Asymptomatic individuals with submicroscopic parasitemia transmitted malaria at a significantly higher rate compared with those with microscopic parasitemia. The high rates of treatment failures with artemether-lumefantrine suggest the need for expanded surveillance programs using molecular methods for accurate monitoring and evaluation of treatment outcomes.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Hannah C. Slater, Brian D. Foy, Kevin Kobylinski, Carlos Chaccour, Oliver J. Watson, Joel Hellewell, Ghaith Aljayyoussi, Teun Bousema, Jeremy Burrows, Umberto D'Alessandro, Haoues Alout, Feiko O. Ter Kuile, Patrick G. T. Walker, Azra C. Ghani, Menno R. Smit
LANCET INFECTIOUS DISEASES
(2020)
Article
Medicine, General & Internal
Xin Hui S. Chan, Yan Naung Win, Ilsa L. Haeusler, Jireh Y. Tan, Shanghavie Loganathan, Sompob Saralamba, Shu Kiat S. Chan, Elizabeth A. Ashley, Karen I. Barnes, Rita Baiden, Peter U. Bassi, Abdoulaye Djimde, Grant Dorsey, Stephan Duparc, Borimas Hanboonkunupakarn, Feiko O. ter Kuile, Marcus V. G. Lacerda, Amit Nasa, Franc Comma Ois H. Nosten, Cyprian O. Onyeji, Sasithon Pukrittayakamee, Andre M. Siqueira, Joel Tarning, Walter R. J. Taylor, Giovanni Valentini, Michele van Vugt, David Wesche, Nicholas P. J. Day, Christopher L-H Huang, Josep Brugada, Ric N. Price, Nicholas J. White
Article
Immunology
Steve M. Taylor, Brandt Levitt, Betsy Freedman, Mwayiwawo Madanitsa, Kyaw-Lay Thwai, Linda Kalilani-Phiri, Carole Khairallah, Victor Mwapasa, Feiko O. ter Kuile, Steven R. Meshnick
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Orvalho Augusto, Andy Stergachis, Stephanie Dellicour, Halidou Tinto, Anifa Vala, Maria Ruperez, Eusebio Macete, Seydou Nakanabo-Diallo, Adama Kazienga, Innocent Valea, Umberto d'Alessandro, Feiko O. ter Kuile, Gregory S. Calip, Peter Ouma, Meghna Desai, Esperanca Sevene
Article
Multidisciplinary Sciences
Bernard Abong'o, John E. Gimnig, Stephen J. Torr, Bradley Longman, Diana Omoke, Margaret Muchoki, Feiko ter Kuile, Eric Ochomo, Stephen Munga, Aaron M. Samuels, Kiambo Njagi, James Maas, Robert T. Perry, Christen Fornadel, Martin J. Donnelly, Richard M. Oxborough
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Anna Maria van Eijk, Asad S. Mannan, Steven A. Sullivan, Jane M. Carlton
Article
Multidisciplinary Sciences
Patrick G. T. Walker, Matt Cairns, Hannah Slater, Julie Gutman, Kassoum Kayentao, John E. Williams, Sheick O. Coulibaly, Carole Khairallah, Steve Taylor, Steven R. Meshnick, Jenny Hill, Victor Mwapasa, Linda Kalilani-Phiri, Kalifa Bojang, Simon Kariuki, Harry Tagbor, Jamie T. Griffin, Mwayi Madanitsa, Azra C. H. Ghani, Meghna Desai, Feiko O. ter Kuile
NATURE COMMUNICATIONS
(2020)
Article
Public, Environmental & Occupational Health
Michelle E. Roh, Feiko O. ter Kuile, Francois Rerolle, M. Maria Glymour, Stephen Shiboski, Roly Gosling, Julie Gutman, Abel Kakuru, Meghna Desai, Richard Kajubi, Anne L'Ianziva, Moses R. Kamya, Grant Dorsey, R. Matthew Chico
LANCET GLOBAL HEALTH
(2020)
Article
Multidisciplinary Sciences
Stephanie R. Lundy, Shakyra Richardson, Anne Ramsey, Debra Ellerson, Yan Fengxia, Sunny Onyeabor, Ward Kirlin, Winston Thompson, Carolyn M. Black, Jason P. DeBruyne, Alec J. Davidson, Lilly C. Immergluck, Uriel Blas-Machado, Francis O. Eko, Joseph U. Igietseme, Qing He, Yusuf O. Omosun
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Palang Chotsiri, Julie R. Gutman, Rukhsana Ahmed, Jeanne Rini Poespoprodjo, Din Syafruddin, Carole Khairallah, Puji B. S. Asih, Anne L'lanziva, Kephas Otieno, Simon Kariuki, Peter Ouma, Vincent Were, Abraham Katana, Ric N. Price, Meghna Desai, Feiko O. ter Kuile, Joel Tarning
Summary: This study evaluated the population pharmacokinetics of piperaquine given as IPTp in pregnant women, finding that providing the full treatment course of DP at monthly intervals can offer optimal prevention of malaria during pregnancy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
T. K. Kwambai, A. Dhabangi, R. Idro, R. Opoka, V Watson, S. Kariuki, N. A. Kuya, E. D. Onyango, K. Otieno, A. M. Samuels, M. R. Desai, M. Boele van Hensbroek, D. Wang, C. C. John, B. Robberstad, K. S. Phiri, F. O. ter Kuile
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Silke Fernandes, Vincent Were, Julie Gutman, Grant Dorsey, Abel Kakuru, Meghna Desai, Simon Kariuki, Moses R. Kamya, Feiko O. ter Kuile, Kara Hanson
LANCET GLOBAL HEALTH
(2020)
Article
Microbiology
Stephanie R. Lundy, Kobe Abney, Debra Ellerson, Joseph U. Igietseme, Darin Carroll, Francis O. Eko, Yusuf O. Omosun
Summary: miR-378b plays a crucial role in the pathological outcomes of Chlamydia infection, affecting host immune responses, Chlamydial replication control, and inflammation processes, which in turn impact human reproductive health and infertility.
Article
Multidisciplinary Sciences
Thandile Nkosi-Gondwe, Bjarne Robberstad, Mavuto Mukaka, Richard Idro, Robert O. Opoka, Saidon Banda, Melf-Jakob Kuhl, Feiko O. Ter Kuile, Bjorn Blomberg, Kamija S. Phiri
Summary: In a trial conducted at Zomba Central Hospital in Southern Malawi, community-based delivery of dihydroartemesinin-piperaquine for post-discharge malaria chemoprevention in children recovering from severe anemia resulted in higher adherence compared to facility-based methods.
Article
Parasitology
Anna Maria van Eijk, Sandhya Choubey, Punam Barla, Mohammed A. Haque, P. Nandini, Subrata Acharya, Steven A. Sullivan, Sanjib Mohanty, Sanghamitra Satpathi, Jane M. Carlton