Article
Infectious Diseases
Guoming Li, Yueming Yuan, Shaoqin Zheng, Chenguang Lu, Mingqiang Li, Ruixiang Tan, Hongying Zhang, Rahamatou Silai, Ruimei Liu, Kamal Said Abdallah, Affane Bacar, Qin Xu, Jianping Song, Wanting Wu, Changsheng Deng
Summary: The study found that artemisinin-piperaquine and artemether-lumefantrine maintained high efficacy and tolerance in treating uncomplicated falciparum malaria in the Comoros. However, asymptomatic malaria infections may pose new challenges to malaria control.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Chemistry, Organic
Patricia S. M. Amado, Luis M. T. Frija, Jaime A. S. Coelho, Paul M. O'Neill, Maria L. S. Cristiano
Summary: A novel protocol for the synthesis of nonsymmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes using heterogeneous silica sulfuric acid (SSA) catalyst has been reported. The method involves different ketones reacting under mild conditions to generate corresponding endoperoxides in good yields, with the assistance of molecular orbital calculations. This approach provides a valid alternative for the synthesis of new biologically active endoperoxides using readily available and inexpensive reagents with recyclable properties.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Medicine, General & Internal
Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Serge-Brice Assi, Jude D. Bigoga, Felix Koukouikila-Koussounda, Nsengi Y. Ntamabyaliro, Francine Ntoumi, Selidji T. Agnandji, Mirjam Groger, Jangsik Shin, Isabelle Borghini-Fuhrer, Sarah Arbe-Barnes, Stephen J. Allen, Peter G. Kremsner, Robert Miller, Stephan Duparc, Michael Ramharter
Summary: In a study conducted in Africa, pyronaridine-artesunate showed good tolerability and effectiveness in the treatment of acute uncomplicated malaria under conditions similar to everyday clinical practice, supporting its use as a useful addition in managing this condition.
Article
Infectious Diseases
Andre Silva-Pinto, Joao Domingos, Margarida Cardoso, Ana Reis, Ernest Diez Benavente, Joao Paulo Caldas, Claudia Conceicao, Cristina Toscano, Teresa Baptista-Fernandes, Taane G. Clark, Kamal Mansinho, Susana Campino, Fatima Nogueira
Summary: The failure of artemisinin combination therapy (ACT) in malaria patients may be due to parasite resistance. There is a need for close monitoring of signs of unsatisfactory anti-malarial efficacy among ACT treated patients, and the possible implication of other genes or mutations in parasite response to ACTs.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Phoebe Hazenberg, Kate Navaratnam, Paula Busuulwa, Catriona Waitt
Summary: Significant anatomical and physiological changes occur during pregnancy and labor, impacting drug absorption, distribution, metabolism, and elimination. Limited data are available on pregnancy-specific pharmacokinetics of anti-infectives, with further research needed to understand the clinical implications of pharmacokinetic differences between pregnant and nonpregnant individuals. Challenges in applying quality grading systems to these studies highlight the need for a refined appraisal system for pharmacokinetic studies in special populations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Ambroise Ahouidi, Rafael Oliveira, Lis Lobo, Cyrille Diedhiou, Souleymane Mboup, Fatima Nogueira
Summary: This study presents the first information on the prevalence of k13-propeller and pfmdr1 mutations in the Sedhiou region of Senegal, contributing to closing the gap in knowledge about anti-malaria drug resistance molecular markers in southern Senegal.
Article
Infectious Diseases
Sri Krishna, Sweta Mishra, Prakash Tiwari, Anup K. Vishwakarma, Sushrikanta Khandai, Suyesh Shrivastava, Anil K. Verma, Shashikant Tiwari, Hari Barman, Surendra Jhariya, Pradeep Tiwari, Anup S. Tidgam, Brij M. Varun, Sunil Singh, Naresh Yerane, Chintaman R. Tembhurne, Prem L. Mandavi, Shyam S. Tekam, Manas Malik, Kali P. Behera, Himanshu Jayswar, Khemraj Sonwani, Mukund S. Diggikar, Madan M. Pradhan, Sher S. Khasotiya, Avdhesh Kumar, Neeraj Dhingra, Maria Dorina G. Bustos, Eva-Maria Christophel, Pascal Ringwald, Roop Kumari, Man M. Shukla, Neeru Singh, Aparup Das, Praveen K. Bharti
Summary: Malaria is a major public health issue in India, with artemether-lumefantrine being shown to be highly effective in treating uncomplicated Plasmodium falciparum malaria. The study findings demonstrate the efficacy of AL across all age groups and the absence of functional k13 gene mutations in the study area.
Article
Biochemistry & Molecular Biology
Hamma Maiga, Anastasia Grivoyannis, Issaka Sagara, Karim Traore, Oumar B. Traore, Youssouf Tolo, Aliou Traore, Amadou Bamadio, Zoumana I. Traore, Kassim Sanogo, Ogobara K. Doumbo, Christopher V. Plowe, Abdoulaye A. Djimde
Summary: The study evaluated the efficacy of artemether-lumefantrine in treating uncomplicated Plasmodium falciparum malaria in Mali. Results showed a high ACPR rate and a decrease in pfcrt 76T and pfmdr1 86Y genotypes associated with drug resistance. The study suggests a potential reintroduction of chloroquine or amodiaquine for future malaria treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Tijs K. Tournoy, Anna Rosanas-Urgell, Marjan Van Esbroeck, Emmanuel Bottieau, Ralph Huits
Summary: We reported a case of Plasmodium malariae malaria in a traveler who returned from the Democratic Republic of Congo to Belgium. This case occurred despite the individual receiving successful treatment for Plasmodium falciparum three weeks earlier and not being re-exposed to the infection in an endemic area. We discussed possible explanations for this unusual observation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
M. Silva, M. Malmberg, S. D. Otienoburu, A. Bjorkman, B. Ngasala, A. Martensson, J. P. Gil, M. I. Veiga
Summary: The study found significant co-expression patterns of the pfmdr1 and pfcrt genes before and during ACT treatment. This co-expression may play an important role when the parasite is exposed to drug stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Tijs K. Tournoy, Anna Rosanas-Urgell, Marjan Van Esbroeck, Emmanuel Bottieau, Ralph Huits
Summary: A traveler was diagnosed with Plasmodium malariae malaria despite having received successful treatment for Plasmodium falciparum three weeks earlier and without re-exposure in an endemic area. Possible explanations for this uncommon observation were discussed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Fatoumata O. Maiga, Mamadou Wele, Sounkou M. Toure, Makan Keita, Cheick Oumar Tangara, Randi R. Refeld, Oumar Thiero, Kassoum Kayentao, Mahamadou Diakite, Antoine Dara, Jian Li, Mahamoudou Toure, Issaka Sagara, Abdoulaye Djimde, Frances J. Mather, Seydou O. Doumbia, Jeffrey G. Shaffer
Summary: This study conducted a systematic review and meta-analysis on ACT at Mali study sites, showing that ACT remains highly efficacious in treating uncomplicated falciparum malaria. Ongoing country-specific meta-analyses on ACT are needed for monitoring drug efficacy patterns, particularly in regions with reported resistance.
Review
Parasitology
Rob W. van der Pluijm, Chanaki Amaratunga, Mehul Dhorda, Arjen M. Dondorp
Summary: Recent progress in the fight against malaria is at risk due to the emergence and spread of artemisinin and partner drug resistance, particularly in the Greater Mekong Subregion. New drugs are not expected in the near future, making it crucial to utilize triple artemisinin-based combination therapies to combat falciparum malaria effectively. Deployment of such therapies beyond the GMS could potentially help prevent global resistance to currently available drugs.
TRENDS IN PARASITOLOGY
(2021)
Article
Medicine, General & Internal
Ben Andagalu, Pinyi Lu, Irene Onyango, Elke Bergmann-Leitner, Ruth Wasuna, Geoffrey Odhiambo, Lorna J. Chebon-Bore, Luicer A. Ingasia, Dennis W. Juma, Benjamin Opot, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Raphael Okoth, Gladys Chemwor, Joseph Campo, Anders Wallqvist, Hoseah M. Akala, Daniel Ochiel, Bernhards Ogutu, Sidhartha Chaudhury, Edwin Kamau
Summary: The study found that pre-existing immunity affects the efficacy of artemisinin combination therapy (ASMQ), but not artemether-lumefantrine (AL). Machine learning models predicted the treatment outcomes of ASMQ, indicating that immune responses may interact with drug half-life to provide long-term efficacy of treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Ben Andagalu, Oliver J. Watson, Irene Onyango, Benjamin Opot, Raphael Okoth, Gladys Chemwor, Peter Sifuna, Dennis Juma, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Jackline Wafubwa, Santos Yalwala, David Abuom, Bernhards Ogutu, Jessica Cowden, Hoseah M. Akala, Edwin Kamau
Summary: This study investigated the transmission dynamics in an asymptomatic population in a high-malaria-burden region in Kenya and identified primary school children as the most important infectious reservoir for malaria transmission. Asymptomatic individuals with submicroscopic parasitemia transmitted malaria at a significantly higher rate compared with those with microscopic parasitemia. The high rates of treatment failures with artemether-lumefantrine suggest the need for expanded surveillance programs using molecular methods for accurate monitoring and evaluation of treatment outcomes.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
J. Scott Overcash, Charles Kim, Richard Keech, Illia Gumenchuk, Borislav Ninov, Yaneicy Gonzalez-Rojas, Michael Waters, Simeon Simeonov, Marc Engelhardt, Mikael Saulay, Daniel Ionescu, Jennifer Smart, Mark E. Jones, Kamal A. Hamed
Summary: The study demonstrated that ceftobiprole is noninferior to vancomycin/aztreonam in the treatment of ABSSSIs, showing comparable early clinical response rates and investigator-assessed clinical success at the TOC visit.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Dermatology
Jing Zhang, Yingyuan Zhang, Depei Wu, Guoying Cao, Kamal Hamed, Amit Desai, Jalal A. Aram, Xuan Guo, Rana Fayyad, Oliver A. Cornely
Summary: The study showed that there were no clinically relevant PK differences between Chinese and Western participants, although Chinese volunteers had higher exposure. In Chinese patients, the efficacy and safety of isavuconazole were similar to the global population.
Article
Immunology
Miroslava Bosheva, Rusudan Gujabidze, Eva Karoly, Agnes Nemeth, Mikael Saulay, Jennifer I. Smart, Kamal A. Hamed
Summary: This study focused on pediatric patients with hospital-acquired pneumonia or community-acquired pneumonia, showing that ceftobiprole is well tolerated and demonstrated similar efficacy to standard-of-care cephalosporins in this population.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Microbiology
Tobias Welte, Thomas W. L. Scheeren, J. Scott Overcash, Mikael Saulay, Marc Engelhardt, Kamal Hamed
Summary: The study evaluated the efficacy and safety of the novel antibiotic ceftobiprole in patients aged 65 and older. Results showed that ceftobiprole offered similar benefits to established antibiotics in older patients with skin infections or pneumonia, with some evidence suggesting a quicker response in older patients. Overall, ceftobiprole was well tolerated and a useful treatment option for infections in older patients.
FUTURE MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Brahima Amara Diallo, Effua Usuf, Omar Ceesay, Umberto D'Alessandro, Anna Roca, Melisa Martinez-Alvarez
Summary: This study aimed to assess the level of community involvement in COVID-19 clinical trials in The Gambia and identify strategies for better engagement. The study found that fear of stigmatization of patients with COVID-19 was a major concern, which affected willingness to accept testing and follow-up visits. Preserving privacy and building trust in the implementing institution were identified as important factors for increasing trial participation.
Article
Infectious Diseases
Leonard R. Duncan, Kamal A. Hamed, Jennifer I. Smart, Michael A. Pfaller, Robert K. Flamm, Rodrigo E. Mendes
Summary: Bone and joint infections (BJIs) are difficult to treat, but ceftobiprole, a broad-spectrum cephalosporin, has shown potent activity against various pathogens in vitro. This study supports further evaluation of ceftobiprole as a potential treatment option for BJIs.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Editorial Material
Microbiology
Jing Zhang, Yingyuan Zhang, Depei Wu, Guoying Cao, Kamal Hamed, Amit Desai, Jalal A. Aram, Xuan Guo, Rana Fayyad, Oliver A. Cornely
FUTURE MICROBIOLOGY
(2022)
Article
Microbiology
Keith A. Rodvold, Justin Bader, Jon B. Bruss, Kamal Hamed
Summary: SPR206, a next-generation polymyxin, shows promise for treating multidrug-resistant (MDR) Gram-negative infections. A Phase 1 bronchoalveolar lavage (BAL) study was conducted to evaluate SPR206's safety and pharmacokinetics in healthy volunteers. The study demonstrates the pulmonary penetration of SPR206 and supports its further development for the treatment of serious infections caused by MDR Gram-negative pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Kamal Hamed, Marc Engelhardt, Laura L. Kovanda, Jin Ju Huang, Jean Yan, Jalal A. Aram
Summary: Isavuconazole was found to have a higher rate of adverse events and lower efficacy in patients aged 65 and above with invasive fungal diseases.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
David Melnick, Angela K. Talley, Vipul K. Gupta, Ian A. Critchley, Paul B. Eckburg, Kamal A. Hamed, Nivedita Bhatt, Gary Moore, Daren Austin, Christopher M. Rubino, Sujata M. Bhavnani, Paul G. Ambrose
Summary: The clinical relevance of bacteriuria after antibiotic treatment of complicated urinary tract infections is controversial. This study evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a clinical trial comparing oral tebipenem pivoxil hydrobromide and intravenous ertapenem. The prolonged urinary clearance and dwell time of ertapenem were associated with a temporal difference in the repopulation of bladder urine with bacteria following treatment, potentially confounding efficacy assessment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Jon B. Bruss, Justin Bader, Kamal A. Hamed
Summary: SPR206 is a novel drug that shows potent activity against multidrug-resistant bacteria. Its safety and pharmacokinetics have been evaluated in patients with varying degrees of renal impairment. The drug was found to be generally safe and well-tolerated, with predictable pharmacokinetic profile.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Kevin L. Winthrop, Patrick Flume, Kamal A. Hamed
Summary: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a challenging condition to manage due to various factors such as the long duration of therapy, low efficacy, drug intolerance, recurrence, and the development of resistance. Current treatment options for NTM-PD are limited, and there is a significant need for new treatments. SPR720 is a promising therapeutic agent that has shown activity against NTM species, including MAC and MAB, without evidence of cross-resistance to standard-of-care agents. It is generally well tolerated with mild to moderate gastrointestinal and headache adverse events.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Medicine, General & Internal
Thomas L. Holland, Sara E. Cosgrove, Sarah B. Doernberg, Timothy C. Jenkins, Nicholas A. Turner, Helen W. Boucher, Oleksander Pavlov, Ivan Titov, Serhii Kosulnykov, Boyko Atanasov, Ivan Poromanski, Manana Makhviladze, Anastasia Anderzhanova, Martin E. Stryjewski, Maziar Assadi Gehr, Marc Engelhardt, Kamal Hamed, Daniel Ionescu, Mark Jones, Mikael Saulay, Jennifer Smart, Harald Seifert, Vance G. Fowler, ERADICATE Study Grp
Summary: The study showed that ceftobiprole was noninferior to daptomycin in treating complicated Staphylococcus aureus bacteremia.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Respiratory System
Kamal A. Hamed, Glenn Tillotson
Summary: This paper provides a comprehensive analysis of NTM infections, covering microbiology, environmental sources and transmission pathways, risk factors, epidemiology, clinical manifestations, diagnostic approaches, treatment recommendations, drugs under development, and management challenges.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Infectious Diseases
Rafael Canton, Kamal Hamed, Tatiana Wiktorowicz, Nowel Redder, Noelle Jemmely, Juan Quevedo, Anne Santerre Henriksen
Summary: This study evaluated the susceptibility of clinical bacterial isolates from hospitalized patients in Europe to ceftobiprole. The results showed that ceftobiprole exhibited potent and broad-spectrum activity against Gram-positive and Gram-negative isolates, with a slight geographical susceptibility gradient.
JAC-ANTIMICROBIAL RESISTANCE
(2022)