Article
Infectious Diseases
Guoming Li, Yueming Yuan, Shaoqin Zheng, Chenguang Lu, Mingqiang Li, Ruixiang Tan, Hongying Zhang, Rahamatou Silai, Ruimei Liu, Kamal Said Abdallah, Affane Bacar, Qin Xu, Jianping Song, Wanting Wu, Changsheng Deng
Summary: The study found that artemisinin-piperaquine and artemether-lumefantrine maintained high efficacy and tolerance in treating uncomplicated falciparum malaria in the Comoros. However, asymptomatic malaria infections may pose new challenges to malaria control.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Andre Silva-Pinto, Joao Domingos, Margarida Cardoso, Ana Reis, Ernest Diez Benavente, Joao Paulo Caldas, Claudia Conceicao, Cristina Toscano, Teresa Baptista-Fernandes, Taane G. Clark, Kamal Mansinho, Susana Campino, Fatima Nogueira
Summary: The failure of artemisinin combination therapy (ACT) in malaria patients may be due to parasite resistance. There is a need for close monitoring of signs of unsatisfactory anti-malarial efficacy among ACT treated patients, and the possible implication of other genes or mutations in parasite response to ACTs.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Hamma Maiga, Anastasia Grivoyannis, Issaka Sagara, Karim Traore, Oumar B. Traore, Youssouf Tolo, Aliou Traore, Amadou Bamadio, Zoumana I. Traore, Kassim Sanogo, Ogobara K. Doumbo, Christopher V. Plowe, Abdoulaye A. Djimde
Summary: The study evaluated the efficacy of artemether-lumefantrine in treating uncomplicated Plasmodium falciparum malaria in Mali. Results showed a high ACPR rate and a decrease in pfcrt 76T and pfmdr1 86Y genotypes associated with drug resistance. The study suggests a potential reintroduction of chloroquine or amodiaquine for future malaria treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Gabriel Kishoyian, Eliud N. M. Njagi, George O. Orinda, Francis T. Kimani, Kevin Thiongo, Damaris Matoke-Muhia
Summary: After a decade of use, artemether-lumefantrine remains highly effective in clearing Plasmodium falciparum parasites in children aged between 6 and 60 months in Kenya. Continued monitoring is essential to prevent potential resistance to the drug in all target users.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Sri Krishna, Sweta Mishra, Prakash Tiwari, Anup K. Vishwakarma, Sushrikanta Khandai, Suyesh Shrivastava, Anil K. Verma, Shashikant Tiwari, Hari Barman, Surendra Jhariya, Pradeep Tiwari, Anup S. Tidgam, Brij M. Varun, Sunil Singh, Naresh Yerane, Chintaman R. Tembhurne, Prem L. Mandavi, Shyam S. Tekam, Manas Malik, Kali P. Behera, Himanshu Jayswar, Khemraj Sonwani, Mukund S. Diggikar, Madan M. Pradhan, Sher S. Khasotiya, Avdhesh Kumar, Neeraj Dhingra, Maria Dorina G. Bustos, Eva-Maria Christophel, Pascal Ringwald, Roop Kumari, Man M. Shukla, Neeru Singh, Aparup Das, Praveen K. Bharti
Summary: Malaria is a major public health issue in India, with artemether-lumefantrine being shown to be highly effective in treating uncomplicated Plasmodium falciparum malaria. The study findings demonstrate the efficacy of AL across all age groups and the absence of functional k13 gene mutations in the study area.
Article
Chemistry, Organic
Patricia S. M. Amado, Luis M. T. Frija, Jaime A. S. Coelho, Paul M. O'Neill, Maria L. S. Cristiano
Summary: A novel protocol for the synthesis of nonsymmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes using heterogeneous silica sulfuric acid (SSA) catalyst has been reported. The method involves different ketones reacting under mild conditions to generate corresponding endoperoxides in good yields, with the assistance of molecular orbital calculations. This approach provides a valid alternative for the synthesis of new biologically active endoperoxides using readily available and inexpensive reagents with recyclable properties.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Infectious Diseases
Fatoumata O. Maiga, Mamadou Wele, Sounkou M. Toure, Makan Keita, Cheick Oumar Tangara, Randi R. Refeld, Oumar Thiero, Kassoum Kayentao, Mahamadou Diakite, Antoine Dara, Jian Li, Mahamoudou Toure, Issaka Sagara, Abdoulaye Djimde, Frances J. Mather, Seydou O. Doumbia, Jeffrey G. Shaffer
Summary: This study conducted a systematic review and meta-analysis on ACT at Mali study sites, showing that ACT remains highly efficacious in treating uncomplicated falciparum malaria. Ongoing country-specific meta-analyses on ACT are needed for monitoring drug efficacy patterns, particularly in regions with reported resistance.
Article
Pharmacology & Pharmacy
M. Silva, M. Malmberg, S. D. Otienoburu, A. Bjorkman, B. Ngasala, A. Martensson, J. P. Gil, M. I. Veiga
Summary: The study found significant co-expression patterns of the pfmdr1 and pfcrt genes before and during ACT treatment. This co-expression may play an important role when the parasite is exposed to drug stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Infectious Diseases
Abdulhakim Abamecha, Daniel Yilma, Wondimagegn Adissu, Delenasaw Yewhalaw, Alemseged Abdissa
Summary: This study aimed to synthesize the evidence on the efficacy of artemether-lumefantrine for uncomplicated falciparum malaria in Ethiopia. The results suggest that this therapy is effective and safe, but strong conclusions cannot be drawn due to high risk of bias in the included studies. Further high-quality RCTs are needed to provide stronger evidence.
Article
Infectious Diseases
Peter Thelma Ngwa Niba, Akindeh Mbuh Nji, Innocent Mbulli Ali, Lawrence Fonyonga Akam, Cedric Hermann Dongmo, Jean Paul Kengne Chedjou, Calvino Tah Fomboh, William Dorian Nana, Ornella Laetitia Ayem Oben, Abdel Aziz Selly-Ngaloumo, Marcel N. Moyeh, Jude Achidi Ngu, Ambassa Jean Ludovic, Pierre Martiniel Aboh, Marie Carine Enyegue Ambani, Pierrette Albertine Mbarga Omgba, Grace Bissohong Kotcholi, Linus Moye Adzemye, Danielle Regine Abenkou Nna, Adele Douanla, Ze Ango, Marie Sophie Ewane, Joel Tewara Ticha, Fritz Mbuh Tatah, Golwa Dinza, Valentine Nchafor Ndikum, Dorothy A. Fosah, Jude D. Bigoga, Michael Alifrangis, Wilfred F. Mbacham
Summary: This study evaluated the effectiveness and safety of AS-AQ and AL for home-based treatment of uncomplicated P. falciparum malaria in Yaounde, Cameroon. The results showed that both AS-AQ and AL were effective and safe for the management of malaria in a home setting.
BMC INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Vy Bui, Colleen R. Higgins, Sarah Laing, Sachiko Ozawa
Summary: This study examines the impact of substandard and falsified antimalarials on health and economy in Benin, showing the significant cost and death associated with poor-quality antimalarials. Replacing all antimalarials with quality-assured artemisinin combination therapies has the potential to save costs and prevent deaths.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Infectious Diseases
Saber Dini, Sophie G. Zaloumis, David J. Price, Nathalie Gobeau, Anne Kummel, Mohammed Cherkaoui, Joerg J. Moehrle, James S. McCarthy, Julie A. Simpson
Summary: The study investigated the efficacy of a combination therapy of two novel drugs, OZ439 and DSM265, using a biologically informed within-host mathematical model. Results showed that this combination therapy can provide above 90% cure rates within safe and tolerable dose ranges.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Ambroise Ahouidi, Rafael Oliveira, Lis Lobo, Cyrille Diedhiou, Souleymane Mboup, Fatima Nogueira
Summary: This study presents the first information on the prevalence of k13-propeller and pfmdr1 mutations in the Sedhiou region of Senegal, contributing to closing the gap in knowledge about anti-malaria drug resistance molecular markers in southern Senegal.
Article
Medicine, General & Internal
Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Serge-Brice Assi, Jude D. Bigoga, Felix Koukouikila-Koussounda, Nsengi Y. Ntamabyaliro, Francine Ntoumi, Selidji T. Agnandji, Mirjam Groger, Jangsik Shin, Isabelle Borghini-Fuhrer, Sarah Arbe-Barnes, Stephen J. Allen, Peter G. Kremsner, Robert Miller, Stephan Duparc, Michael Ramharter
Summary: In a study conducted in Africa, pyronaridine-artesunate showed good tolerability and effectiveness in the treatment of acute uncomplicated malaria under conditions similar to everyday clinical practice, supporting its use as a useful addition in managing this condition.
Article
Public, Environmental & Occupational Health
Vyacheslav Grebenyuk, Frantisek Stejskal, Eva Nohynkova, Ivana Zicklerova, Lenka Richterova, Hana Rohacova, Hanus Rozsypal, Milan Trojanek
Summary: The aim of this study was to evaluate the rates of parasitaemia clearance and the prevalence of treatment failure in patients with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (AL), mefloquine (MQ), and atovaquone-proguanil (AP). The findings demonstrate the superior efficacy of AL compared to other oral antimalarials in early malaria treatment. However, a higher rate of late treatment failure was observed in patients treated with AL, which warrants further investigation of possible dose adjustments, extended regimens, or alternative artemisinin-based combinations.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)