Article
Medicine, General & Internal
Melissa D. Conrad, Victor Asua, Shreeya Garg, David Giesbrecht, Karamoko Niare, Sawyer Smith, Jane F. Namuganga, Thomas Katairo, Jennifer Legac, Rebecca M. Crudale, Patrick K. Tumwebaze, Samuel L. Nsobya, Roland A. Cooper, Moses R. Kamya, Grant Dorsey, Jeffrey A. Bailey, Philip J. Rosenthal
Summary: This study identified multifocal emergence and spread of Plasmodium falciparum with partial resistance to artemisinins in Uganda. The emergence and spread of resistance were predominantly observed in areas where effective malaria control had been discontinued or transmission was unstable.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Molly D. Kaagaard, Luan O. Matos, Anna Engell Holm, Laura Cordeiro Gomes, Alma Wegener, Karine O. Lima, Isabelle V. M. Vieira, Rodrigo Medeiros de Souza, Claudio Romero Farias Marinho, Lars Hviid, Lasse S. Vestergaard, Helena Dominguez, Tor Biering-Sorensen, Philip Brainin, Odison M. Silvestre
Summary: Studies have shown that malaria can cause changes in electrocardiographic (ECG) patterns and pericardial inflammation. This study aimed to investigate the frequency of ECG alterations and pericardial effusion in patients with malaria infection. The results suggest that ECG changes can be useful in detecting pericardial effusion in malaria and that these changes decrease after antimalarial treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Brendan Fries, Carlos A. Guerra, Guillermo A. Garcia, Sean L. Wu, Jordan M. Smith, Jeremias Nzamio Mba Oyono, Olivier T. Donfack, Jose Osa Osa Nfumu, Simon Hay, David L. Smith, Andrew J. Dolgert
Summary: Different population layers performed differently in matching the gold standard distribution at different population densities. Choosing the appropriate population map has a significant impact on burden estimates in a malaria model.
Article
Microbiology
Huong Giang Le, Haung Naw, Jung-Mi Kang, Tuan Cuong Vo, Moe Kyaw Myint, Zaw Than Htun, Jinyoung Lee, Won Gi Yoo, Tong-Soo Kim, Ho-Joon Shin, Byoung-Kuk Na
Summary: This study analyzed the antimalarial drug resistance genes in malaria parasites in the Mandalay region of Myanmar and found substantial levels of mutations conferring antimalarial drug resistance. Continuous monitoring of these mutations is necessary to provide useful information for policymakers.
Article
Infectious Diseases
Sze-Ann Woon, Brioni R. Moore, Moses Laman, Paula Tesine, Lina Lorry, Bernadine Kasian, Phantica Yambo, Gumul Yadi, William Pomat, Kevin T. Batty, Sam Salman, Leanne J. Robinson, Timothy M. E. Davis, Laurens Manning
Summary: This study aimed to assess the safety, tolerability, and relapse rates of ultra-short course high-dose primaquine for uncomplicated malaria in children. The results showed that ultra-short high-dose primaquine was safe and well-tolerated, and early treatment was non-inferior to delayed treatment in preventing Plasmodium vivax infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Rafal S. Sobota, Abby R. Goron, Andrea A. Berry, Jason A. Bailey, Drissa Coulibaly, Matthew Adams, Abdoulaye K. Kone, Bourema Kouriba, Ogobara K. Doumbo, Marcelo B. Sztein, Philip L. Felgner, Christopher V. Plowe, Kirsten E. Lyke, Mahamadou A. Thera, Mark A. Travassos
Summary: This study used a protein microarray to examine malaria exposure in Malian children with different severe malaria syndromes. Children with concurrent cerebral malaria and severe malarial anemia showed a broader prior parasite exposure pattern. Elevated levels of IL-6, IL-8, and IL-10 were also observed in this group. The unique pathophysiology of this severe subtype deserves further investigation.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Multidisciplinary Sciences
Theresa Reiker, Monica Golumbeanu, Andrew Shattock, Lydia Burgert, Thomas A. Smith, Sarah Filippi, Ewan Cameron, Melissa A. Penny
Summary: Individual-based models are essential in the global fight against infectious diseases, but the complexity of the models can pose challenges for calibration. The authors propose using a Bayesian optimization framework to calibrate a complex malaria transmission simulator, resulting in improved fitting outcomes compared to previous calibrations.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Memoona Khan, Haider Nisar, Nuzhat Mushahid
Summary: The study aimed to compare the clinical and laboratory profiles of severe and uncomplicated malaria in Khuzdar, Southern Balochistan, finding a significant association between severe malaria and various symptoms and lab parameters. Furthermore, it was discovered that children with malaria had a significantly higher frequency of complications compared to adult patients. Certain clinical and lab parameters can be used to predict prognosis in malaria, helping to avoid adverse outcomes.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cell Biology
James A. Watson, Sophie Uyoga, Perpetual Wanjiku, Johnstone Makale, Gideon M. Nyutu, Neema Mturi, Elizabeth C. George, Charles J. Woodrow, Nicholas P. J. Day, Philip Bejon, Robert O. Opoka, Arjen M. Dondorp, Chandy C. John, Kathryn Maitland, Thomas N. Williams, Nicholas J. White
Summary: Severe malaria caused by Plasmodium falciparum is difficult to accurately diagnose in children in high-transmission settings. A combination of platelet count and plasma PfHRP2 concentration can be used to identify severe falciparum malaria in severely ill patients. About one-third of children enrolled in clinical studies of severe malaria in high-transmission settings in Africa had other causes of their severe illness.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesen-Ramirez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Summary: The unique three-membrane pellicle is a key feature driving the transition between different life cycle stages of the malaria parasite. A novel subpellicular microtubule-associated protein, SPM3, was identified in the genus Plasmodium. Knockout of this protein resulted in malformed gametocytes and aberrant microtubules in Plasmodium falciparum, while in Plasmodium berghei, it caused perturbed microtubule architecture, aberrant sporozoite motility, and decreased transmission efficiency.
Review
Multidisciplinary Sciences
Yonas Yimam, Mehdi Mohebali, Mohammad Javad Abbaszadeh Afshar
Summary: This study compared the diagnostic performance of a new ultrasensitive rapid diagnostic test (us-RDT) and a conventional rapid diagnostic test (co-RDT) for detecting malaria. The results showed that us-RDT had higher sensitivity, especially in asymptomatic individuals and low transmission areas.
Article
Biotechnology & Applied Microbiology
Jack Adderley, Christian Doerig
Summary: This study fills gaps in the kinomes of Plasmodium falciparum and Plasmodium vivax, highlighting their similarities and differences for target selection. It also identifies kinases that are not suitable targets for drug discovery due to their high similarity with human counterparts.
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Manuela Hauser, Jean-Bertin B. Kabuya, Molly Mantus, Luc K. Kamavu, James L. Sichivula, Wycliffe M. Matende, Nora Fritschi, Timothy Shields, Frank Curriero, Anton Kvit, Gershom Chongwe, William J. Moss, Nicole Ritz, Matthew M. Ippolito
Summary: This study examined the clinical features of malaria in refugee children in high-transmission areas of Africa. The findings showed that refugee children had higher malaria prevalence and mortality rates, partly due to delayed presentation and malnutrition. Interventions tailored to the refugee context, including rapid diagnosis and referral, are necessary to reduce malaria mortality.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Isabell Berneburg, Satyamaheshwar Peddibhotla, Kim C. Heimsch, Kristina Haeussler, Patrick Maloney, Palak Gosalia, Janina Preuss, Mahsa Rahbari, Oleksii Skorokhod, Elena Valente, Daniela Ulliers, Luigi Felice Simula, Kathrin Buchholz, Michael P. Hedrick, Paul Hershberger, Thomas D. Y. Chung, Michael R. Jackson, Evelin Schwarzer, Stefan Rahlfs, Lars Bode, Katja Becker, Anthony B. Pinkerton
Summary: This study reports on a highly selective PfGluPho inhibitor, SBI-0797750, which shows potent activity against Plasmodium parasites. The compound disturbs the redox potential and H2O2 homeostasis of the parasites, without harming red blood cell integrity and phagocytosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Parasitology
Mariama K. Cherif, Guillaume S. Sanou, Edith C. Bougouma, Amidou Diarra, Alphonse Ouedraogo, Amagana Dolo, Marita Troye-Blomberg, David R. Cavanagh, Michael Theisen, David Modiano, Sodiomon B. Sirima, Issa Nebie
Review
Parasitology
Charles Arama, Bakary Maiga, Amagana Dolo, Bourema Kouriba, Boubacar Traore, Peter D. Crompton, Susan K. Pierce, Marita Troye-Blomberg, Louis H. Miller, Ogobara K. Doumbo
Article
Cell Biology
Ioana Bujila, Evelin Schwarzer, Oleksii Skorokhod, Jessica M. Weidner, Marita Troye-Blomberg, Ann-Kristin Ostlund Farrants
CELLULAR MICROBIOLOGY
(2016)
Article
Immunology
Marianne Guenot, Severine Loizon, Jennifer Howard, Giulia Costa, David A. Baker, Shaneel Y. Mohabeer, Marita Troye-Blomberg, Jean-Francois Moreau, Julie Dechanet-Merville, Odile Mercereau-Puijalon, Maria Mamani-Matsuda, Charlotte Behr
INFECTION AND IMMUNITY
(2015)
Article
Infectious Diseases
Jennifer M. G. Shelton, Patrick Corran, Paul Risley, Nilupa Silva, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Rachel Craik, Victoria Cornelius, Meike Hensmann, Sile Molloy, Nuno Sepulveda, Taane G. Clark, Gavin Band, Geraldine M. Clarke, Christopher C. A. Spencer, Angeliki Kerasidou, Susana Campino, Sarah Auburn, Adama Tall, Alioune Badara Ly, Odile Mercereau-Puijalon, Anavaj Sakuntabhai, Abdoulaye Djimde, Boubacar Maiga, Ousmane Toure, Ogobara K. Doumbo, Amagana Dolo, Marita Troye-Blomberg, Valentina D. Mangano, Frederica Verra, David Modiano, Edith Bougouma, Sodiomon B. Sirima, Muntaser Ibrahim, Ayman Hussain, Nahid Eid, Abier Elzein, Hiba Mohammed, Ahmed Elhassan, Ibrahim Elhassan, Thomas N. Williams, Carolyne Ndila, Alexander Macharia, Kevin Marsh, Alphaxard Manjurano, Hugh Reyburn, Martha Lemnge, Deus Ishengoma, Richard Carter, Nadira Karunaweera, Deepika Fernando, Rajika Dewasurendra, Christopher J. Drakeley, Eleanor M. Riley, Dominic P. Kwiatkowski, Kirk A. Rockett
Article
Multidisciplinary Sciences
Odilon Nouatin, Komi Gbedande, Samad Ibitokou, Bertin Vianou, Parfait Houngbegnon, Sem Ezinmegnon, Sophie Borgella, Carine Akplogan, Gilles Cottrell, Stefania Varani, Achille Massougbodji, Kabirou Moutairou, Marita Troye-Blomberg, Philippe Deloron, Adrian J. F. Luty, Nadine Fievet
Article
Immunology
Charles Arama, Jeff Skinner, Didier Doumtabe, Silvia Portugal, Tuan M. Tran, Aarti Jain, Boubacar Traore, Ogobara K. Doumbo, David Huw Davies, Marita Troye-Blomberg, Amagana Dolo, Philip L. Felgner, Peter D. Crompton
OPEN FORUM INFECTIOUS DISEASES
(2015)
Article
Parasitology
Ratchanok Kumsiri, Marita Troye-Blomberg, Kovit Pattanapanyasat, Srivicha Krudsood, Yaowapa Maneerat
Article
Infectious Diseases
Mariama Cherif, Daniel Amoako-Sakyi, Amagana Dolo, Jan-Olov Pearson, Ben Gyan, Dorcas Obiri-Yeboah, Issa Nebie, Sodiomon B. Sirima, Ogobara Doumbo, Marita Troye-Blomberg, Maiga Bakary
Article
Multidisciplinary Sciences
Victor Yman, Michael T. White, Josea Rono, Bruno Arca, Faith H. Osier, Marita Troye-Blomberg, Stephanie Bostrom, Raffaele Ronca, Ingegerd Rooth, Anna Farnert
SCIENTIFIC REPORTS
(2016)
Article
Immunology
Samad A. Ibitokou, Stephanie Bostrom, Laurent Brutus, Nicaise Tuikue Ndam, Bertin Vianou, Carine Agbowai, Martin Amadoudji Zin, Bich Tram Huynh, Achille Massougbodji, Philippe Deloron, Marita Troye-Blomberg, Nadine Fievet, Adrian J. F. Luty
CLINICAL AND VACCINE IMMUNOLOGY
(2014)
Article
Immunology
Akira Kaneko, Luis F. Chaves, George Taleo, Morris Kalkoa, Rie Isozumi, Renu Wickremasinghe, Hedvig Perlmann, Satoru Takeo, Takafumi Tsuboi, Shin-Ichiro Tachibana, Masatsugu Kimura, Anders Bjoerkman, Marita Troye-Blomberg, Kazuyuki Tanabe, Chris Drakeley
INFECTION AND IMMUNITY
(2014)
Review
Medicine, General & Internal
C. Arama, M. Troye-Blomberg
JOURNAL OF INTERNAL MEDICINE
(2014)
Review
Immunology
Marita Troye-Blomberg, Charles Arama, Jaclyn Quin, Ioana Bujila, Ann-Kristin Ostlund Farrants
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Piyatida Tangteerawatana, Srivicha Krudsood, Naowarat Kanchanakhan, Marita Troye-Blomberg, Srisin Khusmith
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
(2014)