Article
Parasitology
Kazuhiko Nakayama, Yuta Kimura, Yu Kitahara, Akira Soga, Asako Haraguchi, Jun Hakozaki, Makoto Sugiyama, Kodai Kusakisako, Shinya Fukumoto, Hiromi Ikadai
Summary: The knockdown of ookinete surface and oocyst capsule protein (OSCP) in the parasite reduces ookinete motility and the number of oocysts, potentially aiding in the development of a transmission-blocking tool for malaria.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Charlie Jennison, Janna M. Armstrong, Dorender A. Dankwa, Nina Hertoghs, Sudhir Kumar, Biley A. Abatiyow, Myo Naung, Nana K. Minkah, Kristian E. Swearingen, Robert Moritz, Alyssa E. Barry, Stefan H. I. Kappe, Ashley M. Vaughan
Summary: Plasmodium parasites, the eukaryotic pathogens that cause malaria, have three distinct invasive forms adapted to different host environments. Micronemes, a type of secretory organelle, play crucial roles in egress, motility, adhesion, and invasion. This study demonstrates that GPI-anchored micronemal antigen (GAMA) is involved in sporozoite motility, egress, and invasion, suggesting its role as a regulator of microneme function. The findings also show conservation of GAMA's function across Plasmodium species.
MOLECULAR MICROBIOLOGY
(2023)
Article
Parasitology
Peng-peng Wang, Xuefeng Jiang, Jie Bai, Fan Yang, Xinxin Yu, Yudi Wu, Wenqi Zheng, Yongzhe Zhang, Liwang Cui, Fei Liu, Xiaotong Zhu, Yaming Cao
Summary: This study identified PSOP26 as a surface protein expressed in Plasmodium gametes and ookinetes, and found that it plays a critical role in the zygote-to-ookinete developmental transition. PSOP25 is a promising candidate for TBVs targeting the ookinete stage.
PARASITES & VECTORS
(2022)
Article
Parasitology
Mayumi Tachibana, Hideyuki Iriko, Minami Baba, Motomi Torii, Tomoko Ishino
Summary: The development and traversal of Plasmodium parasites in the mosquito midgut is a major bottleneck in the parasite's life cycle. PSOP1 protein is predicted to be involved in migration across the midgut wall, and its localization in micronemes suggests a role in parasite-host interactions during ookinete penetration.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Immunology
Chiamaka V. Ukegbu, George K. Christophides, Dina Vlachou
Summary: Plasmodium falciparum malaria remains a major cause of global morbidity and mortality, primarily in sub-Saharan Africa. Despite stable numbers of new cases and deaths in recent years, efforts for disease elimination are ongoing but new approaches are needed. Researchers have identified three new genes - PIMMS01, PIMMS57, and PIMMS22 - that play important roles in the formation of ookinetes and could serve as new targets for intervention strategies to block malaria transmission.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tianyang Liu, Fiona Shilliday, Alexander D. Cook, Mohammad Zeeshan, Declan Brady, Rita Tewari, Colin J. Sutherland, Anthony J. Roberts, Carolyn A. Moores
Summary: In this study, the authors investigated the role of Plasmodium kinesin-8B in microtubule motility and depolymerization. They found that kinesin-8B is essential for the formation of male gametes and parasite transmission. The study provides important insights into the molecular mechanisms underlying malaria transmission.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda
Summary: This study reveals the crucial role of transcriptional activity in Plasmodium zygotes, especially the function of a novel transcription factor AP2-Z, in promoting ookinete development. The findings suggest the existence of a transcription factor cascade and provide potential target genes for understanding Plasmodium zygote/ookinete development and developing transmission blocking vaccines.
Article
Immunology
Min-Ju Kim, Ki-Back Chu, Hae-Ji Kang, Keon-Woong Yoon, Dong-Hun Lee, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan
Summary: The study showed that VLP vaccines containing AMA1 and MIC can induce higher levels of antibody responses and increase specific cell populations. VLP vaccination also suppressed inflammatory responses, reduced parasitic infection and related symptoms, demonstrating the potential as a blood-stage vaccine for malaria.
Article
Multidisciplinary Sciences
Zhu-Hong Li, Thayer P. King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A. Vella, Isabelle Coppens, Sandip Patel, Silvia N. J. Moreno
Summary: This study characterizes a TPC from Toxoplasma gondii that localizes to the apicoplast, playing a critical role in maintaining its integrity and facilitating Ca2+ uptake from the ER through stabilizing inter-organelle contact.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zhenke Yang, Yang Shi, Huiting Cui, Shuzhen Yang, Han Gao, Jing Yuan
Summary: This study identifies the presence of a Plasmodium flippase in the midgut epithelium, which is essential for parasite survival and mosquito transmission.
Article
Infectious Diseases
Min-Ju Kim, Ki-Back Chu, Su-Hwa Lee, Hae-Ji Kang, Keon-Woong Yoon, Md Atique Ahmed, Fu-Shi Quan
Summary: Recombinant vaccinia viruses (rVV) expressing either AMA1 or MIC were compared for their efficacies as vaccine candidates in mice. Both vaccines elicited parasite-specific antibody responses and high levels of T cell and germinal center B cell responses. However, MIC vaccine induced higher levels of cellular immune response and significantly reduced pro-inflammatory cytokine productions compared to AMA1 vaccine. Prolonged survival was observed in mice immunized with MIC vaccine. These findings suggest that MIC could be a more promising vaccine candidate antigen.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Leonel Vargas-Jaimes, Maria Carmen Rodriguez, Rocio Argotte-Ramos, Victor Rivelino Juarez-Gonzalez, Nina Pastor, Catherine Cesa-Luna, Lourival D. Possani, Veronica Quintero-Hernandez
Summary: Malaria is a parasitic disease caused by protozoa and transmitted through infected mosquitoes. Scorpion venom contains peptides with antiplasmodial properties, which have shown promising results in inhibiting the development of parasites responsible for malaria. Constructed C-terminal domains from Scorpine-like peptides demonstrated significant antiplasmodial activity, making them potential candidates for combating malaria.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Infectious Diseases
Issaka Sagara, Sara A. Healy, Mahamadoun H. Assadou, Mamady Kone, Bruce J. Swihart, Jennifer L. Kwan, Jonathan Fintzi, Kourane Sissoko, Bourama Kamate, Yacouba Samake, Merepen A. Guindo, M'Bouye Doucoure, Karamoko Niare, Amagana Dolo, Balla Diarra, Kelly M. Rausch, David L. Narum, David S. Jones, Nicholas J. Macdonald, Daming Zhu, J. Patrick Gorres, Alemush Imeru, Rathy Mohan, Ismaila Thera, Irfan Zaidi, Fernando Salazar-Miralles, Junhui Duan, Jillian Neal, Robert D. Morrison, Olga Muratova, Daman Sylla, Elise M. O'Connell, Yimin Wu, Jen C. C. Hume, Mamadou B. Coulibaly, Charles F. Anderson, Sekou F. Traore, Ogobara K. Doumbo, Patrick E. Duffy
Summary: The Pfs230D1 vaccine induces durable serum functional activity in Malian adults, suggesting its potential effectiveness in malaria prevention.
LANCET INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Teresa Cruz-Bustos, Anna Sophia Feix, Manolis Lyrakis, Marlies Dolezal, Barbel Ruttkowski, Anja Joachim
Summary: In this study, the transcriptional profiles of different developmental stages of the apicomplexan parasite Cystoisospora suis were analyzed in vitro. The expression of genes encoding proteins involved in gametes biology, oocyst wall biosynthesis, DNA replication, and axonema formation as well as a homologue of a tyrosine-rich protein in Toxoplasma gondii were identified. The inhibition of sexual development in C. suis by specific antiserum was evaluated, providing potential targets for control strategies against C. suis transmission.
SCIENTIFIC REPORTS
(2022)
Review
Parasitology
Jenna Oberstaller, Thomas D. Otto, Julian C. Rayner, John H. Adams
Summary: Genome-scale mutagenesis screens have been completed in three species of apicomplexan parasites, leading to the identification of core essential genes and potential areas for new interventions across the phylum Apicomplexa.
TRENDS IN PARASITOLOGY
(2021)
Article
Cell Biology
Adela Nacer, Aurelie Claes, Amy Roberts, Christine Scheidig-Benatar, Hiroshi Sakamoto, Mehdi Ghorbal, Jose-Juan Lopez-Rubio, Denise Mattei
CELLULAR MICROBIOLOGY
(2015)
Article
Immunology
A. Nacer, D. Carapau, R. Mitchell, A. Meltzer, A. Shaw, U. Frevert, E. H. Nardin
MUCOSAL IMMUNOLOGY
(2014)
Review
Immunology
U. Frevert, A. Nacer
PARASITE IMMUNOLOGY
(2013)
Article
Parasitology
Adela Nacer, Karen Walker, Hilary Hurd
PARASITES & VECTORS
(2008)
Review
Parasitology
Ute Frevert, Adela Nacer, Mynthia Cabrera, Alexandru Movila, Maike Leberl
PARASITOLOGY INTERNATIONAL
(2014)
Article
Multidisciplinary Sciences
Adela Nacer, Emeric Roux, Sebastien Pomel, Christine Scheidig-Benatar, Hiroshi Sakamoto, Frank Lafont, Artur Scherf, Denise Mattei
Article
Microbiology
Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A. Mikolajczak, Stefan H. I. Kappe, Ute Frevert
Article
Microbiology
Adela Nacer, Alexandru Movila, Fabien Sohet, Natasha M. Girgis, Uma Mahesh Gundra, P'ng Loke, Richard Daneman, Ute Frevert
Article
Immunology
Ute Frevert, Adela Nacer
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2014)
Review
Cell Biology
Mariana De Niz, Adela Nacer, Friedrich Frischknecht
CELLULAR MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adela Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Summary: This study identifies three antibodies that have synergistic effects on a malaria vaccine candidate and demonstrates that lateral interactions between the antibodies slow dissociation and inhibit parasite growth. Understanding the mechanisms of antibody synergy is crucial for vaccine design and antibody cocktail development.
NATURE COMMUNICATIONS
(2022)
Review
Parasitology
A Nacer, L Berry, C Slomianny, D Mattei
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2001)
Article
Parasitology
Victoria Carter, Adela M. L. Nacer, Ann Underhill, Robert E. Sinden, Hilary Hurd
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2007)