Article
Medicine, General & Internal
Valentina Brancato, Giuseppe Della Pepa, Lutgarda Bozzetto, Marilena Vitale, Giovanni Annuzzi, Luca Basso, Carlo Cavaliere, Marco Salvatore, Angela Albarosa Rivellese, Serena Monti
Summary: Dixon-based methods provide a non-invasive and easy way to detect and analyze fatty liver, while covering the entire liver during the process. This study aimed to assess the feasibility of using a whole-liver Dixon-based approach for liver fat quantification in type 2 diabetes patients, and compared two different dietary treatments. The results showed that the Dixon-based approach was effective in quantifying hepatic steatosis in T2D patients and outperformed the standard liver fat analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-Jiao Cao, Wen-Jun Wu, Jing-Wen Chen, Xiang-Ming Fang, Ye Ren, Xiao-Wen Zhu, Hai-Yan Cheng, Qun-Feng Tang
Summary: This study assessed the relationship between ectopic fat deposition in the liver and pancreas, as measured by Dixon MRI, and insulin sensitivity and β-cell function in patients with central obesity.
EUROPEAN RADIOLOGY
(2023)
Article
Physics, Multidisciplinary
Christoph Zoellner, Sophia Kronthaler, Kilian Weiss, Christof Boehm, Jonathan Stelter, Juergen Rahmer, Peter Boernert, Johannes M. Peeters, Daniela Junker, Dimitrios C. Karampinos
Summary: This study proposed a retrospective trajectory correction method based on gradient modulation transfer function (GMTF) measurement to predict and correct gradient chain induced k-space trajectory errors. Experimental results showed that the GMTF correction effectively reduced PDFF quantification errors and improved liver PDFF estimation.
FRONTIERS IN PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dingyi Lin, Ziyan Wang, Hong Li, Hongxi Zhang, Liping Deng, Hong Ren, Shuiya Sun, Fenping Zheng, Jiaqiang Zhou, Min Wang
Summary: Pancreatic fat accumulation is associated with various diseases, but its pathophysiology and imaging diagnostics have not received enough attention. This study used the nnU-Net model to automatically measure the distribution of pancreatic fat deposition on Dixon MRI in multicenter/population datasets. The results showed that the 3D dual-contrast model had the best performance, accurately assessing the distribution of pancreatic fat and demonstrating high reliability.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tess Armstrong, Xiaodong Zhong, Shu-Fu Shih, Ely Felker, David S. Lu, Brian M. Dale, Holden H. Wu
Summary: This study evaluated liver PDFF and R2* quantification in patients with fatty liver disease using free-breathing radial MRI techniques with and without self-gating motion compensation. The results showed that self-gated free-breathing radial MRI achieved comparable results to reference breath-hold techniques for quantifying PDFF, but self-gating was necessary for accurate R2* quantification. The radial sampling factor influenced PDFF and R2* quantification, while radial self-gating temporal resolution only affected R2* quantification.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Fan Zhao, Genming Zhang, Zhongjian Tan, Tengxiao Liang, Fangliang Xing
Summary: This study presents a 3D quantification methodology using Dixon MRI image analysis to evaluate the distribution of liver fat fraction. The method is non-invasive and accurate, applicable to both healthy livers and fatty livers. By extracting the 3D structure of the liver, it visualizes and quantifies the differences in liver fat content.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yonghong Zheng, Shengsheng Yang, Xianyuan Chen, Jieqin Lv, Jiawei Su, Shun Yu
Summary: This study used the MR Dixon method to quantify the fat fraction in the liver and pancreas of patients with type 2 diabetes mellitus and healthy controls. The results showed that tissue fat content is closely related to type 2 diabetes, regardless of BMI values.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aurelie D'Hondt, Erika Rubesova, Hua Xie, Vijay Shamdasani, Richard A. Barth
Summary: This study evaluated four ultrasound technologies for quantitative assessment of liver fat content in children and found that attenuation coefficient and HRI accurately detected and quantified liver fat. Ultrasound parameters may guide the diagnosis and management of NAFLD in children.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaodong Zhong, Tess Armstrong, Chang Gao, Marcel D. Nickel, Fei Han, Brian M. Dale, Xinzhou Li, Sevgi G. Kafali, Peng Hu, Holden H. Wu, Vibhas Deshpande
Summary: An accelerated k-space shift calibration method was developed for free-breathing 3D stack-of-radial MRI quantification of liver proton-density fat fraction (PDFF) and R2*, showing substantial acceleration feasibility in both through-plane and in-plane directions. Compared to baseline calibration without acceleration, Bayesian analysis revealed no significant differences in biases and uncertainties of PDFF and R2* measurements with all acceleration methods, except for one specific method in the phantom study. The proposed method achieved a six-fold reduction in equivalent calibration acquisition time for in vivo protocols.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan Syvaeri, Daniela Junker, Lisa Patzelt, Katharina Kappo, Loubna Al Sadat, Sonia Erfanian, Marcus R. Makowski, Hans Hauner, Dimitrios C. Karampinos
Summary: The study found significant differences in liver fat fraction changes in different liver lobes and Couinaud segments during a long-term lifestyle intervention study, with larger changes observed in the right liver lobe. This highlights the need to spatially resolve liver fat fraction changes in longitudinal studies.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juergen Machann, Maytee Hasenbalg, Julia Dienes, Robert Wagner, Arvid Kohn, Victor Fritz, Andreas L. Birkenfeld, Konstantin Nikolaou, Stephanie Kullmann, Fritz Schick, Martin Heni
Summary: The study evaluated short-term intraday variations of pancreatic fat (PF) and intrahepatic lipids (IHL) after a high-fat meal as well as medium-term changes after 5 days of high-caloric diet, showing that time of day and nutritional status have no significant influence on PF/IHL.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Oncology
Zhenshan Shi, Dairong Cao, Qian Zhuang, Ruixiong You, Xiumei Li, Zhongmin Li, Yueming Li, Xinming Huang
Summary: Pancreatic schwannoma usually presents as a well-circumscribed oval or round pancreatic mass with MRI showing low signal on T1-weighted imaging, inhomogeneous high signal on T2-weighted imaging, and high signal on diffusion-weighted imaging. The tumor demonstrates early slight enhancement on dynamic contrast-enhanced MRI, with progressive enhancement at portal venous and delayed phases.
Article
Clinical Neurology
Alicia Alonso-Jimenez, Claudia Nunez-Peralta, Paula Montesinos, Jorge Alonso-Perez, Carme Garcia, Elena Montiel, Izaskun Belmonte, Irene Pedrosa, Sonia Segovia, Jaume Llauger, Jordi Diaz-Manera
Summary: Quantitative MRI is a valuable method in monitoring disease progression in muscular disorders by measuring changes in muscle fat content over time. In a study with late onset Pompe disease patients, three different methods of analysis of 2-point-dixon images were compared. While significant differences were found between the three methods in estimating fat fraction, the increment in fat fraction over time showed no variation. Correlation with muscle function tests indicated that analyzing individual muscles may be the most reliable approach in certain situations.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela Plaikner, Lukas Lanser, Christian Kremser, Guenter Weiss, Benjamin Henninger
Summary: The study compares the measurement of splenic and pancreatic iron content using a commercial 3D-Dixon sequence (qDixon) and an established fat-saturated R2* relaxometry method (ME-GRE). The results show good concordance between the two methods, with the qDixon sequence proving to be a reliable tool for non-invasive evaluation of iron content in the spleen and pancreas.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xueyin Liao, Xiaoqi Wang, Zhentan Xu, Shiwei Guo, Congmin Gu, Zhengyu Jin, Tong Su, Yu Chen, Huadan Xue, Mingyong Yang
Summary: This study suggests that using T1W fat-only images produced by Dixon MRI is an effective method for identifying grafted fat and quantifying postoperative changes. The signal contrast and retention rate decrease gradually after surgery.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Endocrinology & Metabolism
K. S. Weber, K. Strassburger, G. Pacini, B. Nowotny, K. Muessig, J. Szendroedi, C. Herder, M. Roden
Article
Cardiac & Cardiovascular Systems
Christian Herder, Imke Schamarek, Bettina Nowotny, Maren Carstensen-Kirberg, Klaus Strassburger, Peter Nowotny, Julia M. Kannenberg, Alexander Strom, Sonja Puettgen, Karsten Muessig, Julia Szendroedi, Michael Roden, Dan Ziegler
Article
Endocrinology & Metabolism
Sabine Kahl, Bettina Nowotny, Klaus Strassburger, Alessandra Bierwagen, Birgit Klueppelholz, Barbara Hoffmann, Guido Giani, Peter J. Nowotny, Franziska Wallscheid, Erifili Hatziagelaki, Giovanni Pacini, Jong-Hee Hwang, Michael Roden
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Medicine, Research & Experimental
Elisa Alvarez Hernandez, Sabine Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, Peter Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G. Jones, Johannes Beckers, Martin Hrabe de Angelis, Michael Roden
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Endocrinology & Metabolism
Maria Apostolopoulou, Barbara Menart-Houtermans, Ruth Ruetter, Bettina Nowotny, Ulrich Gehrmann, Daniel Markgraf, Julia Szendroedi, Nanette C. Schloot, Michael Roden
ACTA DIABETOLOGICA
(2018)
Article
Endocrinology & Metabolism
Bettina Nowotny, Sabine Kahl, Birgit Klueppelholz, Barbara Hoffmann, Guido Giani, Roshan Livingstone, Peter J. Nowotny, Valerie Stamm, Christian Herder, Andrea Tura, Giovanni Pacini, Jong-Hee Hwang, Michael Roden
METABOLISM-CLINICAL AND EXPERIMENTAL
(2018)
Article
Ophthalmology
Katharina Schroeder, Julia Szendroedi, Anna Benthin, Veronika Gontscharuk, Philipp Ackermann, Magdalena Voelker, Nadine Steingrube, Bettina Nowotny, Dan Ziegler, Karsten Muessig, Gerd Geerling, Oliver Kuss, Michael Roden, Rainer Guthoff
ACTA OPHTHALMOLOGICA
(2019)
Article
Nutrition & Dietetics
Yanislava Karusheva, Lejla Kunstein, Alessandra Bierwagen, Bettina Nowotny, Stefan Kabisch, Jan B. Groener, Ann Kristin Fleitmann, Christian Herder, Giovanni Pacini, Klaus Strassburger, Hans-Ulrich Haering, Peter P. Nawroth, Andreas F. H. Pfeiffer, Volker Burkart, Karsten Muessig, Michael Roden, Julia Szendroedi
NUTRITION & METABOLISM
(2018)
Article
Endocrinology & Metabolism
Marie-Christine Simon, Akiko Moeller-Horigome, Klaus Strassburger, Bettina Nowotny, Birgit Knebel, Karsten Muessig, Christian Herder, Julia Szendroedi, Michael W. Roden
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Pharmacology & Pharmacy
Herbert Wiesinger, Stefan Klein, Antje Rottmann, Bettina Nowotny, Kai Riecke, Isabella Gashaw, Margarete Brudny-Kloeppel, Robert Fricke, Joachim Hoechel, Christian Friedrich
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Medicine, General & Internal
Hanna Kampling, Birgit Koehler, Isabell Germerott, Burkhard Haastert, Andrea Icks, Bernd Kulzer, Bettina Nowotny, Norbert Hermanns, Johannes Kruse
Summary: This study investigated the effectiveness of a psychodynamically oriented short-term therapy program in reducing diabetes distress and improving glycemic control. The results showed a significant reduction in HbA1c levels, as well as improvements in diabetes distress and depressive symptoms in the intervention group.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Kalman Bodis, Birgit Knebel, Bettina Nowotny, Pavel Bobrov, Yuliya Kupriyanova, Oana-Patricia Zaharia, Yanislava Karusheva, Martin Schoen, Martin Wolkersdorfer, Volker Burkart, Hadi Al-Hasani, Daniel Markgraf, Karsten Muessig, Michael Roden, Julia Szendroedi
Summary: Carriers heterozygous for the D124N variant of GCK not only exhibit reduced insulin secretion, but also impaired adipose insulin sensitivity, potentially leading to fatty acid accumulation in the liver and dysglycemia.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Hematology
Bettina Nowotny, Dirk Thomas, Stephan Schwers, Sara Wiegmann, Wolfgang Prange, Ashraf Yassen, Stefanie Boxnick
Summary: BAY 1831865, a humanized monoclonal antibody targeting factor XI, was well tolerated in healthy volunteers when administered via intravenous or subcutaneous injection, with no evidence of bleeding or adverse reactions reported. The drug showed dose-dependent prolongation of activated partial thromboplastin time and sustained inhibition of factor XI.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Michael Boettcher, Bettina Nowotny, Robert Krausche, Corina Becker
Summary: This study aimed to investigate the safety and tolerability of co-administration of vericiguat and sildenafil in healthy volunteers. The results showed that the combination of vericiguat and sildenafil had minimal effects on blood pressure and heart rate and was well tolerated. Sildenafil did not affect the pharmacokinetics of vericiguat.
CLINICAL PHARMACOKINETICS
(2023)
Article
Immunology
Christian Herder, Jan-Felix Fuerstos, Bettina Nowotny, Alexander Begun, Klaus Strassburger, Karsten Muessig, Julia Szendroedi, Andrea Icks, Michael Roden
BRAIN BEHAVIOR AND IMMUNITY
(2017)