期刊
MAGNETIC RESONANCE IN MEDICINE
卷 74, 期 1, 页码 249-259出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.25401
关键词
quantitative MRI; osteoarthritis; cartilage; human; rotating frame relaxation
资金
- Academy of Finland [128603, 260321]
- NIH [P41 EB015894]
- Academy of Finland (AKA) [128603] Funding Source: Academy of Finland (AKA)
PurposeTo evaluate the sensitivity of quantitative MRI techniques (T-1, T-1,T-Gd, T-2, continous wave (CW) T-1 dispersion, adiabatic T-1, adiabatic T-2, RAFF and inversion-prepared magnetization transfer (MT)) for assessment of human articular cartilage with varying degrees of natural degeneration. MethodsOsteochondral samples (n=14) were obtained from the tibial plateaus of patients undergoing total knee replacement. MRI of the specimens was performed at 9.4T and the relaxation time maps were evaluated in the cartilage zones. For reference, quantitative histology, OARSI grading and biomechanical measurements were performed and correlated with MRI findings. ResultsAll MRI parameters, except T-1,T-Gd, showed statistically significant differences in tangential and full-thickness regions of interest (ROIs) between early and advanced osteoarthritis (OA) groups, as classified by OARSI grading. CW-T-1 showed significant dispersion in all ROIs and featured classical laminar structure of cartilage with spin-lock powers below 1000 Hz. Adiabatic T-1, T-2, CW-T-1,T- MT, and RAFF correlated strongly with OARSI grade and biomechanical parameters. ConclusionMRI parameters were able to differentiate between early and advanced OA. Furthermore, rotating frame methods, namely adiabatic T-1, adiabatic T-2, CW-T-1, and RAFF, as well as MT experiment correlated strongly with biomechanical parameters and OARSI grade, suggesting high sensitivity of the parameters for cartilage degeneration. Magn Reson Med 74:249-259, 2015. (c) 2014 Wiley Periodicals, Inc.
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