Article
Radiology, Nuclear Medicine & Medical Imaging
Michael A. Bush, Yue Pan, Ning Jin, Yingmin Liu, Juliet Varghese, Rizwan Ahmad, Orlando P. Simonetti
Summary: Respiratory motion in cardiovascular MRI poses challenges, but a patient-specific prospective motion correction (PROCO) method is shown to reduce spatial variation in myocardial T(1)and T(2)mapping techniques. This technique allows for efficient free-breathing acquisitions with improved accuracy.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Carmen P. S. Blanken, Eric M. Schrauben, Eva S. Peper, Lukas M. Gottwald, Bram F. Coolen, Diederik F. van Wijk, Jan J. Piek, Gustav J. Strijkers, R. Nils Planken, Pim van Ooij, Aart J. Nederveen
Summary: The study introduced a framework for accelerated 4D flow MRI for repeatable quantification of coronary blood flow, which showed good agreement with 2D flow MRI results.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Gino Gulamhussene, Marko Rak, Oleksii Bashkanov, Fabian Joeres, Jazan Omari, Maciej Pech, Christian Hansen
Summary: This study improves the reconstruction quality and reduces acquisition time of deep learning-based 4D MRI methods for organ motion models through transfer learning and an ensembling strategy.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adam Johansson, James M. Balter, Yue Cao
Summary: A new GI 4D MRI technique is presented in this study, which can clearly visualize periodic gastrointestinal motion without interference from respiratory motion. This technique may help define internal target volumes for treatment planning, aid in planning organ at risk volume definition, or support motion model development for gastrointestinal motion tracking algorithms.
Article
Radiology, Nuclear Medicine & Medical Imaging
Juliane Ludwig, Peter Speier, Frank Seifert, Tobias Schaeffter, Christoph Kolbitsch
Summary: Prospective motion correction using the pilot tone as a respiratory motion signal improved image quality and scan efficiency for cardiac cine imaging, with significant improvement in contrast-to-noise ratio and sharpness of endocardium.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Paul Neofytou, Radhouene Neji, Grzegorz Tomasz Kowalik, Ronald Mooiweer, James Wong, Anastasia Fotaki, Joana Ferreira, Carl Evans, Filippo Bosio, Nabila Mughal, Reza Razavi, Kuberan Pushparajah, Sebastien Roujol
Summary: A motion-robust reconstruction technique called REMAKE and its variant REMAKE+ were developed for free-breathing cine imaging with multiple averages. Both techniques effectively reduced motion artifacts and improved myocardial sharpness, image quality, and the rate of diagnostic quality images. However, REMAKE+ had a tendency to maintain higher blood/myocardial SNR and myocardial-blood CNR compared to REMAKE.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sihao Chen, Tyler J. Fraum, Cihat Eldeniz, Joyce Mhlanga, Weijie Gan, Thomas Vahle, Uday B. Krishnamurthy, David Faul, H. Michael Gach, Michael M. Binkley, Ulugbek S. Kamilov, Richard Laforest, Hongyu An
Summary: The impact of PET respiratory motion correction (MoCo) was evaluated using MRI-assisted methods in both a phantom and patients with hepatic lesions. The results demonstrated that this approach improved quantitative and qualitative metrics of PET images, as well as lesion conspicuity.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weiwei Ruan, Fang Liu, Xun Sun, Fan Hu, Tingfan Wu, Yongxue Zhang, Xiaoli Lan
Summary: This study evaluated two respiratory correction methods for abdominal PET/MRI images and found that multi-bin respiratory gating was more effective than end-expiratory respiratory gating for respiratory motion correction. However, the increase in noise in gated images due to discarding PET data is a limitation of the multi-bin respiratory gating method.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cemre Ariyurek, Tess E. Wallace, Tobias Kober, Sila Kurugol, Onur Afacan
Summary: This study evaluates the feasibility of using FID navigators for real-time prospective motion measurement and correction. The results indicate that the proposed method can accurately track and correct the position of the kidneys, improving the quality of kidney imaging.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Calder D. Sheagren, Tianle Cao, Jaykumar H. Patel, Zihao Chen, Hsu-Lei Lee, Nan Wang, Anthony G. Christodoulou, Graham A. Wright
Summary: T1 mapping is a magnetic resonance imaging method used for diagnosing myocardial diseases, and has potential for improving patient comfort and information density. Motion-corrected and motion-resolved T1 mapping represent future directions for development.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jakob M. Slipsager, Stefan L. Glimberg, Liselotte Hojgaard, Rasmus R. Paulsen, Paul Wighton, M. Dylan Tisdall, Camilo Jaimes, Borjan A. Gagoski, P. Ellen Grant, Andre van Der Kouwe, Oline V. Olesen, Robert Frost
Summary: Comparing prospective motion correction (PMC) and retrospective motion correction (RMC) in Cartesian 3D-encoded MPRAGE scans showed that PMC resulted in superior image quality compared to RMC, with increasing correction frequency reducing motion artifacts in RMC.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
Yung-Chin Hsua, Wen-Yih Isaac Tseng
Summary: This paper proposes a registration-based algorithm to correct various distortions or artifacts commonly observed in diffusion-weighted magnetic resonance images. The algorithm uses anatomical images and a pseudo diffusion MRI data for registration, and estimates the models of artifacts simultaneously. The evaluation shows that the method accurately estimates model parameters and effectively reduces artifacts. This method is beneficial for most dMRI data, especially those acquired without additional field maps or reverse phase-encoding images.
Review
Engineering, Biomedical
F. Lamare, A. Bousse, K. Thielemans, C. Liu, T. Merlin, H. Fayad, D. Visvikis
Summary: This article provides a comprehensive overview of the development in the field of PET respiratory motion correction, covering different multimodality imaging devices and approaches including synchronization, estimation, and motion correction.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julian Hossbach, Daniel Nicolas Splitthoff, Stephen Cauley, Bryan Clifford, Daniel Polak, Wei-Ching Lo, Heiko Meyer, Andreas Maier
Summary: This study introduces a novel method for retrospective motion correction in clinical MRI of the head, which combines classical model-driven and data-consistency approaches with a deep learning algorithm. The motion parameters are estimated using a DL network, and integrated into an iterative data-consistency driven motion correction algorithm. The results demonstrate that this method improves image quality while reducing computation time.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobias Wilferth, Max Mueller, Lena Gast, Laurent Ruck, Martin Meyerspeer, Alfredo L. Lopez Kolkovsky, Michael Uder, Arnd Doerfler, Armin M. Nagel
Summary: This study evaluates the feasibility of motion correction for sodium MRI using interleaved acquired 3D proton navigator images. The motion information obtained from co-registration was used to correct the sodium image dataset, improving image quality and consistency. The results demonstrate that this approach successfully improves the accuracy of quantitative sodium MRI.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Imran Rashid, Giulia Ginami, Giovanna Nordio, Anastasia Fotaki, Radhouene Neji, Harith Alam, Kuberan Pushparajah, Alessandra Frigiola, Israel Valverde, Rene M. Botnar, Claudia Prieto
Summary: Noncontrast enhanced magnetization transfer and inversion recovery prepared 3D free-breathing sequence (MTC-BOOST) has clinical utility in improving the imaging quality and contrast ratio of pulmonary veins and regions characterized by accelerated or turbulent blood flow in patients with congenital heart disease (CHD), with excellent agreement with standard T2prep-3DWH imaging.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Camila Munoz, Anastasia Fotaki, Rene M. Botnar, Claudia Prieto
Summary: This article reviews methods for accelerating magnetic resonance imaging (MRI) data acquisition by exploiting redundancies in the temporal, spatial, and contrast/parametric dimensions. It discusses techniques that separately exploit each dimension and more advanced techniques that combine multiple dimensions. The article also addresses future directions for multidimensional image acceleration and remaining technical challenges.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew Phair, Gastao Cruz, Haikun Qi, Rene M. Botnar, Claudia Prieto
Summary: In this study, a novel free-running framework was introduced for the simultaneous acquisition of 3D whole-heart myocardial T-1 and T-2 maps and cine images. The proposed method was validated and compared with established methods, showing good quality image reconstruction and accurate measurements of T-1 and T-2 values.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shohei Fujita, Katsuhiro Sano, Gastao Cruz, Yuki Fukumura, Hideo Kawasaki, Issei Fukunaga, Yuichi Morita, Masami Yoneyama, Koji Kamagata, Osamu Abe, Kenichi Ikejima, Rene M. Botnar, Claudia Prieto, Shigeki Aoki
Summary: This study compared liver MR fingerprinting with other quantitative MRI techniques and found high agreement between the measurements. Furthermore, liver MR fingerprinting was correlated with histologic grading and showed high diagnostic performance.
Article
Cardiac & Cardiovascular Systems
Katharine E. Thomas, Anastasia Fotaki, Rene M. Botnar, Vanessa M. Ferreira
Summary: Myocardial inflammation leads to changes in the myocardial tissue, which can be detected using cardiovascular magnetic resonance imaging. Various techniques, such as T2-weighted imaging, parametric T1- and T2-mapping, and contrast-enhanced imaging, have been used to identify myocardial inflammation and its effects. Emerging techniques aim to simultaneously image multiple parameters to better characterize myocardial tissue and detect subtle immune-mediated changes. This review outlines the principles of current and emerging cardiovascular magnetic resonance methods for imaging myocardial inflammation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Anastasia Fotaki, Carlos Velasco, Claudia Prieto, Rene M. Botnar
Summary: Cardiometabolic disease refers to a range of chronic conditions that affect cardiovascular health, such as diabetes, hypertension, atheromatosis, and non-alcoholic fatty liver disease. MR methods enable non-invasive characterization of myocardial and liver tissue, providing valuable information on fibrosis, perfusion changes, edema, and iron levels. These techniques have shown potential as early diagnostic biomarkers and may have prognostic implications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Camila Munoz, Anastasia Fotaki, Alina Hua, Reza Hajhosseiny, Karl P. P. Kunze, Tevfik F. F. Ismail, Radhouene Neji, Kuberan Pushparajah, Rene M. Botnar, Claudia Prieto
Summary: This study characterized the performance of a fast and respiratory motion-compensated three-dimensional (3D) cardiac MRI technique for simultaneous contrast-free imaging of the aortic lumen and vessel wall. The results showed that this technique improved image quality and contrast ratio, shortened scan time, and provided complementary 3D black-blood images. Measurements of aortic diameter and vessel wall thickness demonstrated good agreement with other imaging methods, and there was good interreader and intrareader agreement.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carlos Castillo-Passi, Ronal Coronado, Gabriel Varela-Mattatall, Carlos Alberola-Lopez, Rene Botnar, Pablo Irarrazaval
Summary: Koma is an open-source, high-performance, easy-to-use, extensible, cross-platform, and general MRI simulation framework developed using the Julia programming language. It solves the Bloch equations with excellent execution speed and accuracy. Through comparative experiments and user studies, the usability and performance advantages of Koma were demonstrated. In terms of quantitative imaging, Koma was used for simulating Magnetic Resonance Fingerprinting (MRF) acquisitions. In conclusion, Koma has important applications in education and research.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gastao Cruz, Alina Hua, Camila Munoz, Tevfik Fehmi Ismail, Amedeo Chiribiri, Rene Michael Botnar, Claudia Prieto
Summary: The purpose of this study is to develop a novel approach for accelerated 2D free-breathing myocardial perfusion using low-rank motion-corrected (LRMC) reconstructions. The proposed framework incorporates LRMC models and high-dimensionality patch-based regularization to produce high-quality, motion-corrected myocardial perfusion series. The results show that LRMC achieves significantly improved image quality compared to other reconstruction methods in terms of image sharpness, temporal fidelity, and expert evaluation.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Gastao Cruz, Kerstin Hammernik, Thomas Kuestner, Carlos Velasco, Alina Hua, Tevfik Fehmi Ismail, Daniel Rueckert, Rene Michael Botnar, Claudia Prieto
Summary: The aim of this study was to develop a novel approach for obtaining 2D breath-hold cardiac cine imaging from a single heartbeat using motion-corrected reconstructions and nonrigidly aligned patch-based regularization. The proposed method, called MC-CINE, significantly improved image quality compared to itSENSE and XD-GRASP in terms of image sharpness, reader scoring, reader ranking, and left ventricular assessment.
NMR IN BIOMEDICINE
(2023)
Article
Biophysics
Begona Lavin, Thomas R. Eykyn, Alkystis Phinikaridou, Aline Xavier, Shravan Kumar, Xabier Buque, Patricia Aspichueta, Carlos Sing-Long, Marco Arrese, Rene M. Botnar, Marcelo E. Andia
Summary: Noninvasive imaging techniques like magnetic resonance imaging and magnetic resonance spectroscopy can be used to diagnose and stage the progression of NAFLD and monitor treatment response in an eNOS(-/-) mouse model.
NMR IN BIOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Nadia Chaher, Giuseppe Digilio, Sara Lacerda, Rene M. Botnar, Alkystis Phinikaridou
Summary: Fibrosis is a reparative response to tissue injury, but excessive fibrosis can be detrimental. Collagen plays a key role in fibrosis, particularly type I and type III collagen. However, immobilizing collagen for stable coatings is challenging due to various experimental conditions. This study provides a detailed protocol for reproducibly immobilizing and quantifying type I and III collagens, as well as investigating their interactions with collagen-binding compounds. This approach has broad applications in biomedicine, including molecular imaging, drug development, and cell studies.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Fotaki, Kuberan Pushparajah, Reza Hajhosseiny, Alina Schneider, Harith Alam, Joana Ferreira, Radhouene Neji, Karl P. Kunze, Alessandra Frigiola, Rene M. Botnar, Claudia Prieto
Summary: The purpose of this study was to evaluate the clinical performance of the three-dimensional, free-breathing, Magnetization Transfer Contrast Bright-and-black blOOd phase-SensiTive (MTC-BOOST) sequence in adult congenital heart disease (ACHD). The results showed that the MTC-BOOST sequence had shorter scan time, higher diagnostic confidence, and provided efficient, high-quality, and contrast agent-free three-dimensional whole-heart imaging in ACHD. Overall, the MTC-BOOST sequence showed significant improvement compared to the clinical sequence. Rating: 8 out of 10.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Guglielmo, Sophie Rier, Giulia De Zan, Axel J. Krafft, Michaela Schmidt, Karl P. Kunze, Rene M. Botnar, Claudia Prieto, Jeroen van der Heijden, Vincent Van Driel, Hemanth Ramanna, Pim van der Harst, Ivo van der Bilt
Summary: This study evaluated whether cardiac magnetic resonance (CMR) can identify incomplete pulmonary vein antrum isolation (PVAI-L) immediately after radiofrequency catheter ablation (RFCA). The results showed that using 3D-TWILITE and 3D-LGE, PVAI-L can be visualized, while DB-STIR cannot accurately identify the ablation core.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gregory Wood, Alexandra Uglebjerg Pedersen, Karl P. Kunze, Radhouene Neji, Reza Hajhosseiny, Jens Wetzl, Seung Su Yoon, Michaela Schmidt, Bjarne Linde Norgaard, Claudia Prieto, Rene M. Botnar, Won Yong Kim
Summary: Deep learning-derived automated software can effectively and efficiently determine the optimal trigger delay for coronary MRA acquisition, simplifying workflow and improving reproducibility.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)