Article
Radiology, Nuclear Medicine & Medical Imaging
Rajiv S. Deshpande, Michael C. Langham, Cheng-Chieh Cheng, Felix W. Wehrli
Summary: In this study, a pulse sequence called MOTIVE was developed to simultaneously measure blood flow rate and venous oxygen saturation for quantifying cerebral metabolic rate of oxygen (CMRO2). The MOTIVE sequence showed good reproducibility and agreement with traditional methods. It has the advantage of shorter scan time and does not require a control image.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Optics
Fenghe Zhong, Song Hu
Summary: Multi-parametric photoacoustic microscopy (PAM) enables simultaneous high-resolution mapping of blood oxygenation and flow in vivo, but its speed is limited by dense sampling for blood flow quantification. To overcome this limitation, a high-speed multi-parametric PAM system was developed, combining rapid optical scanning with the mechanical scan of the optical-acoustic dual foci. A novel optical-acoustic combiner (OAC) and a resonant galvanometer (GM) were implemented to achieve confocal alignment and stabilized high-speed scanning. This system allows continuous monitoring of microvascular blood oxygenation (sO(2)) and flow in the awake mouse brain with high spatial and temporal resolutions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen P. A. Baas, Bram F. Coolen, Esben T. Petersen, Bart J. Biemond, Gustav J. Strijkers, Aart J. Nederveen
Summary: This study compared T-2-TRIR with TRUST in measuring T(2)b, Yv, and OEF. The results showed that T-2-TRIR-derived T(2)b values were higher, resulting in higher Yv estimates and lower OEF estimates.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Manli Wang, Xi Chen, Long Niu, Jianli Xu, Hang Yu, Xiaojiao Xu, Qiu Yang, Yang Xiang, Weidong Le
Summary: The aim of this study was to explore the molecular mechanism underlying Alzheimer's disease (AD) pathologies. The results showed that blood oxygen saturation in AD mice was significantly reduced in the early stages, along with decreased red blood cell counts and hemoglobin concentrations, which may contribute to the development of predictive markers for AD diagnosis. Furthermore, increased expression of band 3 protein and elevated levels of soluble Aβ40 and Aβ42 may cause deformation of red blood cells and subsequent AD development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Erik Hedstrom, Marjolein Piek, Sebastian Bidhult-Johansson, Daniel Ryd, Frederik Testud, Johannes Toger, Anthony H. Aletras
Summary: The purpose of this study was to evaluate the errors in fetal noninvasive oxygen saturation measurements and explore potential solutions for achieving accurate and precise results. The study examined T-2-prepared bSSFP data in various settings and assessed the impact of different factors on the accuracy of measurements. The findings indicate that although improvements can be made, it is currently not feasible to use these methods for predicting disease.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Optics
Rutendo Jakachira, Mbaye Diouf, Zixi Lin, Joshua A. Burrow, Andrew Howes, Teniola Oguntolu, Robert Carter, Shira Dunsiger, Kimani C. Toussaint
Summary: This study presents a novel PPG technique that uses radially polarized light generated by an LED to obtain single-shot blood oxygen saturation measurements. It enables fast and accurate measurements at a high rate, which is an improvement over conventional techniques.
Article
Biochemical Research Methods
Thomas Kirchner, Michael Jaeger, Martin Frenz
Summary: This study presents a method for quantitative imaging of blood oxygen saturation (sO(2)) based on optoacoustic imaging, combining multispectral and multiple illumination techniques with learned spectral decoloring. The method shows promising results in accurately estimating sO(2) in both in silico and in vivo experiments.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Materials Science, Multidisciplinary
Yibo Lv, Guobiao Cen, Wanjun Li, Chuanxi Zhao, Wenjie Mai
Summary: This study explores the high-quality low bandgap triple cation Sn-Pb perovskite films and fabricates a near-infrared photodetector with enhanced photoresponse. The photodetector demonstrates applicability in a pulse oximetry system, enabling accurate assessment of heart rate and blood oxygen saturation.
SCIENCE CHINA-MATERIALS
(2023)
Article
Neurosciences
Omer Faruk Gulban, Saskia Bollmann, Laurentius (Renzo) Huber, Konrad Wagstyl, Rainer Goebel, Benedikt A. Poser, Kendrick Kay, Dimo Ivanov
Summary: This study provides a dataset of measured T 2* values in the living human brain using 7 Tesla MRI at a mesoscopic scale. The dataset includes visualizations that reveal fine-scale cortical substructures and demonstrates consistent T * 2 values across subjects. This dataset is important for anatomical investigations of the human brain and improving our understanding of the T 2*-weighted (f)MRI signal.
Review
Engineering, Biomedical
Shuwen Chen, Jiaming Qi, Shicheng Fan, Zheng Qiao, Joo Chuan Yeo, Chwee Teck Lim
Summary: This paper outlines and discusses advanced flexible wearable sensors for monitoring cardiovascular vital signals, highlighting functional materials, configurations, mechanisms, and recent advances, as well as discussing challenges, possible strategies, and future directions. With rapid development, these flexible wearable sensors have the potential to be applied for both medical diagnosis and daily healthcare use in addressing cardiovascular diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Neurosciences
Xiao-Xiao Ma, Hai-Yi Xie, Pin-Pin Hou, Xiao-Jing Wang, Wei Zhou, Zhen-Hong Wang
Summary: This study found that low concentrations of normobaric oxygen (NBO) have a neuroprotective effect on cerebral ischemia/reperfusion (I/R) injury by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Rui Dong, Yuewu Li, Sijia Liu, Weitao Li, Ling Tao, Chunxiao Chen, Zhiyu Qian, Yamin Yang
Summary: This study developed a multifunctional microdevice for quantitatively extracting the dominant role of RBC concentration, local oxygen, and fluid dynamics in erythrocyte oxygenation. The microdevice achieved serial dilution of RBCs and exposed them to a linear oxygen gradient using buried microchannels and a gas-permeable membrane. The integrated optical-fiber-based measurement system captured the spectroscopic features of RBCs. The experimental results were consistent with numerical simulation results.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Article
Chemistry, Multidisciplinary
Zijin Zhao, Baiqiao Liu, Changlin Xie, Yao Ma, Jian Wang, Ming Liu, Kaixuan Yang, Yunhua Xu, Jian Zhang, Weiwei Li, Liang Shen, Fujun Zhang
Summary: The bottom surface of the active layer and the interface near the ITO electrode play a crucial role in the performance of PM-PPDs, with the bottom interface being more sensitive and inducing efficient charge tunneling injection. High EQE and fast response time were achieved with PMBBDT:Y6 as the active layer under forward bias, attributing to efficient hole tunneling injection from the ITO electrode. Additionally, PM-PPDs were successfully used to measure heart rate and blood oxygen saturation, yielding similar results to commercial photodetectors.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Thanh Dat Le, Jung-Joon Min, Changho Lee
Summary: Acoustic-resolution photoacoustic microscopy (AR-PAM) enables visualization of biological tissues at depths of several millimeters with superior optical absorption contrast. However, the lateral resolution and sensitivity of AR-PAM are generally lower than those of optical-resolution PAM (OR-PAM) owing to the intrinsic physical acoustic focusing mechanism. In this study, a computational strategy using two generative adversarial networks (GANs) was employed to perform semi/unsupervised reconstruction with high resolution and sensitivity in AR-PAM.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Santhosh M. Baby, Joseph F. Discala, Ryan Gruber, Paulina M. Getsy, Feixiong Cheng, Derek S. Damron, Stephen J. Lewis
Summary: The study demonstrated that Tempol is capable of reversing the negative effects of morphine on arterial blood-gas chemistry in freely-moving rats, with improvements in pO(2), pCO(2), and Alveolar-arterial gradient.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Venkatagiri Krishnamurthy, Lisa C. Krishnamurthy, M. Lawson Meadows, Mary K. Gale, Bing Ji, Kaundinya Gopinath, Bruce Crosson
Summary: A novel method based on independent component analysis was developed to denoise spatio-temporally varying task-correlated motion artifacts in fMRI activation maps. The proposed method outperformed other approaches in removing false positive activity related to task-correlated motion and maintaining a balance between noise removal and signal retention. The denoising approach showed potential implications on clinical metrics and relationship between TCM artifact and speech fluency in persons with aphasia.
HUMAN BRAIN MAPPING
(2021)
Review
Neurosciences
Hahnsung Kim, Lisa C. Krishnamurthy, Phillip Zhe Sun
Summary: This article discusses the importance of homeostasis and pH regulation for normal tissue metabolism and physiology, as well as the alteration of brain tissue pH in diseased states. It reviews the development and challenges of noninvasive tissue pH mapping techniques, with a focus on CEST pH imaging. The article provides examples of emerging pH imaging applications in tumors and discusses CEST pH imaging in acute stroke, highlighting the potential value of CEST pH imaging.
Article
Geriatrics & Gerontology
Antoine Hone-Blanchet, Anastasia Bohsali, Lisa C. Krishnamurthy, Salman Shahid, Qixiang Lin, Liping Zhao, David Loring, Felicia Goldstein, Samantha E. John, Candace C. Fleischer, Allan Levey, James Lah, Deqiang Qiu, Bruce Crosson
Summary: The elevated expression of beta-amyloid and tau are considered risk factors for Alzheimer's disease. This study found that levels of frontal GABA+ and mI/tCr are influenced by age, with GABA+ levels decreasing with age and the opposite for mI/tCr.
NEUROBIOLOGY OF AGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chuang Wang, Jinsoo Uh, Tushar Patni, Thomas Merchant, Yimei Li, Chia-ho Hua, Sahaja Acharya
Summary: This study aimed to generate synthetic relative proton stopping power (sRPSP) images from magnetic resonance imaging (MRI) for proton planning and develop an online quality assurance (QA) tool for accurate integration into clinical practice. Results showed that sRPSP images generated from single T1W or T2W sequences outperformed those from multi-MRI sequences in terms of error, with preprocessing further reducing errors.
Article
Neuroimaging
Olivia C. Haller, Holly A. Aleksonis, Lisa C. Krishnamurthy, Tricia Z. King
Summary: White matter hyperintensities (WMHs) are positively correlated with apathy and executive dysfunction in survivors of pediatric cerebellar brain tumor. These results suggest that WMH burden may serve as a useful marker to identify survivors at risk of executive dysfunction or increased apathy.
NEUROIMAGE-CLINICAL
(2022)
Article
Oncology
Vadim P. Moskvin, Fakhriddin Pirlepesov, Yue Yan, Ozgur Ates, William J. Myers, Jinsoo Uh, Li Zhao, Nadav Shapira, Yoad Yagil, Thomas E. Merchant, Chia-ho Hua
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenbo Li, Feng Xu, Dan Zhu, Peter C. M. van Zijl, Qin Qin
Summary: In this study, a T-2-oximetry method was developed for quantitative mapping of cerebral venous oxygenation fraction using FT-VS pulse trains. The results showed that the FT-VS-based methods yielded higher venous blood signal and temporal SNR with less CSF contamination compared to the traditional approach.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Oncology
J. Uh, J. A. Jordan, A. S. Pappo, M. J. Krasin, C. Hua
Summary: The purpose of this study is to characterize the changes in tumor volume in children with parameningeal rhabdomyosarcoma receiving upfront proton therapy with concurrent chemotherapy. The findings suggest that there is a significant reduction in tumor volume within three weeks after simulation, indicating a need for on-treatment imaging at this time point.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dapeng Liu, Dan Zhu, Feng Xu, Farzad Sedaghat, Qin Qin
Summary: The purpose of this study was to develop velocity selective arterial spin labeling (VSASL) protocols for prostate blood flow (PBF) and prostate blood volume (PBV) mapping. Fourier-transform based velocity-selective inversion and saturation pulse trains were used to obtain blood flow and blood volume weighted perfusion signal in VSASL sequences. The study found that a low cutoff velocity of 0.25-0.50 cm/s was necessary for adequate perfusion signal in both PBF and PBV measurements in prostate.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Zhu, Feng Xu, Dapeng Liu, Argye Elizabeth Hillis, Doris Lin, Peter C. M. van Zijl, Qin Qin
Summary: This study compared the performance of 3D SOS-TFL and 3D GRASE for ASL at 3T and found that 3D SOS-TFL can achieve similar results with fewer shots and higher temporal resolution. It also has minimal relaxation-induced blurring and reduced CSF contamination, making it especially suitable for VSASL.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Feng Xu, Dapeng Liu, Dan Zhu, Argye E. Hillis, Arnold Bakker, Anja Soldan, Marilyn S. Albert, Doris D. M. Lin, Qin Qin
Summary: This MRI study evaluated the test-retest reliability of VSI-prepared 3D VSASL protocol to measure baseline CBF variations in different brain regions among cognitively normal participants. The study found that both absolute and relative CBF showed higher variability, but could still detect normal variations using VSASL.
Article
Engineering, Biomedical
Jinsoo Uh, Chuang Wang, Jacob A. Jordan, Fakhriddin Pirlepesov, Jared B. Becksfort, Ozgur Ates, Matthew J. Krasin, Chia-Ho Hua
Summary: This study developed a novel method to generate synthetic CT (sCT) from CBCT of the abdomen/pelvis with gas pockets, improving the accuracy of proton range estimation for proton therapy. The hybrid method combining CycleGAN and DIR effectively generated the geometry-weighted and intensity-weighted components of sCT, resulting in more accurate CT numbers and better similarity in gas regions compared to deformed pCT or CycleGAN-only sCT. The hybrid method also showed advantages in proton range verification and adaptive replanning.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Ozgur Ates, Jinsoo Uh, Fakhriddin Pirlepesov, Chia-Ho Hua, Brandon Triplett, Amr Qudeimat, Akshay Sharma, Thomas E. Merchant, John T. Lucas Jr
Summary: This study addresses the challenge of respiratory motion in pediatric patients undergoing proton therapy for total lymphoid irradiation (TLI). The research concludes that 4D plan evaluation and robust optimization techniques can help address respiratory motion challenges in proton TLI treatments. Patient-specific respiratory motion evaluations are crucial to ensure adequate dosimetric coverage in proton therapy for pediatric patients.
Article
Oncology
Jared Becksfort, Jinsoo Uh, Andrew Saunders, Julia A. Byrd, Hannah M. Worrall, Matt Marker, Christian Melendez-Suchi, Yimei Li, Jenghwa Chang, Kavitha Raghavan, Thomas E. Merchant, Chia-ho Hua
Summary: This study investigates the setup uncertainty in brain tumor patients undergoing image-guided proton therapy. Daily cone-beam computed tomography (CBCT) scans were performed, and statistical approaches were used to calculate and correct manual setup errors, measure residual errors, and assess intrafractional motion. The study found that CBCT reduced the 95th percentile of setup uncertainty, and there was a larger variation in roll corrections reported by radiographs compared to CBCT. The study also showed that anesthetized patients had lower intrafractional motion. The findings provide important insights for designing safe and optimal proton treatments.
Article
Oncology
Chuang Wang, Jinsoo Uh, Thomas E. Merchant, Chia-ho Hua, Sahaja Acharya
Summary: The novel cycle-GAN model with self-attention outperforms conventional cycle-GAN for children with brain tumors. Encouraging dosimetric results suggest that sCT generation can be used to identify patients who would benefit from adaptive replanning.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2022)