期刊
MAGNETIC RESONANCE IN MEDICINE
卷 69, 期 5, 页码 1245-1252出版社
WILEY-BLACKWELL
DOI: 10.1002/mrm.24371
关键词
xenon; M13 bacteriophage; hyperCEST; cryptophane
资金
- NSERC
- U.S. Department of Energy [DE-AC02-05CH11231]
- U.S. Department of Defense Breast Cancer Research Program [BC061995]
A hyperpolarized 129Xe contrast agent composed of many cryptophane-A molecular cages assembled on an M13 bacteriophage has been demonstrated. Saturation of xenon bound in the large number of cryptophane cages is transferred to the pool of aqueous-solvated xenon via chemical exchange, resulting in efficient generation of hyperCEST contrast. No significant loss of contrast per cryptophane cage was observed for the multivalent phage when compared with unscaffolded cryptophane. Detection of this phage-based hyperCEST agent is reported at concentrations as low as 230 fM, representing the current lower limit for NMR/MRI-based contrast agents. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.
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