期刊
MAGNETIC RESONANCE IN MEDICINE
卷 67, 期 6, 页码 1644-1655出版社
WILEY
DOI: 10.1002/mrm.23153
关键词
cardiac MRI; T1 mapping; image registration; motion correction; MOLLI
资金
- Intramural NIH HHS [ZIA HL006136-02, Z99 HL999999, ZIA HL004607-14, ZIA HL006136-01] Funding Source: Medline
Quantification of myocardial T1 relaxation has potential value in the diagnosis of both ischemic and nonischemic cardiomyopathies. Image acquisition using the modified Look-Locker inversion recovery technique is clinically feasible for T1 mapping. However, respiratory motion limits its applicability and degrades the accuracy of T1 estimation. The robust registration of acquired inversion recovery images is particularly challenging due to the large changes in image contrast, especially for those images acquired near the signal null point of the inversion recovery and other inversion times for which there is little tissue contrast. In this article, we propose a novel motion correction algorithm. This approach is based on estimating synthetic images presenting contrast changes similar to the acquired images. The estimation of synthetic images is formulated as a variational energy minimization problem. Validation on a consecutive patient data cohort shows that this strategy can perform robust nonrigid registration to align inversion recovery images experiencing significant motion and lead to suppression of motion induced artifacts in the T1 map. Magn Reson Med, 2011. (c) 2011 Wiley-Liss, Inc.
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