Article
Biotechnology & Applied Microbiology
A. M. Moerman, S. Korteland, K. Dilba, K. van Gaalen, D. H. J. Poot, A. van der Lugt, H. J. M. Verhagen, J. J. Wentzel, A. F. W. van der Steen, F. J. H. Gijsen, K. van der Heiden
Summary: This study investigated the relationship between wall shear stress (WSS) and plaque composition in advanced atherosclerosis. The findings revealed that high time-averaged WSS (TAWSS) is associated with larger macrophage areas and necrotic core sizes, while low oscillatory shear index (OSI) is associated with larger macrophage areas. Moreover, a combination of low TAWSS and low OSI is related to larger cap thickness.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biology
Romana Perinajova, Joe F. Juffermans, Jos J. M. Westenberg, Roel L. F. van der Palen, Pieter J. van den Boogaard, Hildo J. Lamb, Sasa Kenjeres
Summary: The study reveals that aortic aneurysm is associated with aberrant blood flow and wall shear stress, which can be studied through MRI and CFD. Attention should be paid to the effect of MRI segmentation variations on wall shear stress in patient-specific simulations. Comparing mean and maximal values of WSS in different segments of the thoracic aorta shows good to excellent correlation for rescan, while voxel-to-voxel comparison yields poorer results.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tarmo Korpela, S. Petteri Kauhanen, Elina Kariniemi, Petri Saari, Timo Liimatainen, Pekka Jaakkola, Ritva Vanninen, Marja Hedman
Summary: In this study, the growth rate of dilatation of the ascending aorta (AA) was evaluated using four-dimensional (4D) flow magnetic resonance imaging (MRI). The results showed that flow displacement (FD) and decreased wall shear stress were associated with significant growth of AA dilatation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Edward Ferdian, David J. Dubowitz, Charlene A. Mauger, Alan Wang, Alistair A. Young
Summary: Wall shear stress (WSS) is an important factor in vessel wall remodeling and atherosclerosis. The accuracy of WSS estimation from 4D Flow MRI is limited by spatial resolution. To address this, researchers have developed a deep learning algorithm (WSSNet) trained on aortic computational fluid dynamics (CFD) simulations. The results show that WSSNet accurately estimates WSS and performs better than existing methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Grigorios M. Karageorgos, Paul Kemper, Changhee Lee, Rachel Weber, Nancy Kwon, Nirvedh Meshram, Nima Mobadersany, Julien Grondin, Randolph S. Marshall, Eliza C. Miller, Elisa E. Konofagou
Summary: This study aims to develop an ultrasound imaging technique that combines vector flow imaging with unsupervised data clustering to detect the region close to the wall with optimal linear flow profile and estimate the wall shear stress (WSS) accurately. The technique was evaluated in phantoms and simulations, showing good accuracy and similarity. It was also tested in atherosclerotic swine models and human subjects, demonstrating its feasibility in detecting pre-clinical atherosclerosis.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Review
Cardiac & Cardiovascular Systems
Jiaxing Jason Qin, Peyman Obeidy, Mustafa Gok, Alireza Gholipour, Stuart M. M. Grieve
Summary: The current intervention guidelines for BAV-associated AAo dilatation are not accurate predictors of clinical outcomes. This review examines the relationship between WSS and aortopathy in the BAV population, aiming to identify better biomarkers for risk stratification. The review includes 26 studies that demonstrate the elevated WSS magnitude and circumferential WSS in BAV patients, highlighting the potential of WSS as a valid biomarker for BAV aortopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Guiling Zhang, Shun Zhang, Yuanyuan Qin, Jicheng Fang, Xiangyu Tang, Li Li, Yiran Zhou, Di Wu, Su Yan, Weiyin Vivian Liu, Wenzhen Zhu
Summary: This study found that patients with high-risk plaques had higher wall shear stress (WSS) values throughout the entire cardiac cycle compared to those with low-risk plaques, with the difference being more significant in the axial direction. Additionally, 3D WSS values best reflected the differences between high-risk and low-risk plaques. High WSS, especially during diastole and in the axial direction, may be a signal of high-risk plaque and could lead to cerebrovascular events in patients with moderate carotid artery stenosis.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Kristine Dilba, Dianne H. K. van Dam-Nolen, Suze-Anne Korteland, Anja G. van der Kolk, Mohamed Kassem, Daniel Bos, Peter J. Koudstaal, Paul J. Nederkoorn, Jeroen Hendrikse, M. Eline Kooi, Frank J. H. Gijsen, Anton F. W. van der Steen, Aad van der Lugt, Jolanda J. Wentzel
Summary: In this study, ulcers in carotid plaques were not exclusively located at regions exposed to the highest WSS, OSI, or RRT. However, high WSS and low RRT regions had significantly higher odds of ulceration within the plaque, even after adjustment for wall thickness.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Schmidt, Sebastian Flassbeck, Sonja Schmelter, Ellen Schmeyer, Mark E. Ladd, Sebastian Schmitter
Summary: The study examined how displacement artifacts in 4D flow measurements impact the accuracy of WSS estimates. Different timing schemes were used, with FAST leading to underestimation of WSS values and ECHO resulting in biased values within the stenosis. Computational fluid dynamics simulations showed that the bias in WSS due to displacement artifacts increases with higher spatial resolutions.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Mechanics
Rupali Pandey, Pramod Kumar Yadav
Summary: This study utilizes computational fluid dynamics techniques to investigate the significance of different blood viscosity models in simulating blood flow in a multi-stenosed Left Coronary Artery model. The study reveals that blood velocity increases proportionally with the level of blockage and Reynolds number. Analysis of wall shear stress shows two peaks for all Reynolds numbers, indicating two areas of constriction.
Article
Computer Science, Interdisciplinary Applications
Nina Shokina, Gabriel Teschner, Andreas Bauer, Cameron Tropea, Herbert Egger, Juergen Hennig, Axel J. Krafft
Summary: A novel parametric sequential method for MRI-based WSS quantification is presented, with validation through in vitro and in vivo experiments showing basic applicability.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Biology
Yash T. Katakia, Satyadevan Kanduri, Ritobrata Bhattacharyya, Srinandini Ramanathan, Ishan Nigam, Bhanu Vardhan Reddy Kuncharam, Syamantak Majumder
Summary: The angle of blood vessel bifurcation is an important determinant of atherosclerosis and endothelial dysfunction, as it can alter hemodynamics and impact endothelial structure and function.
COMMUNICATIONS BIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Peter J. Psaltis
Summary: This study investigates the relationship between twelve multi-directional/topological wall shear stress (WSS) derived metrics and the formation of coronary plaques using computational fluid dynamics (CFD) and dynamic fluid-structure interaction (FSI) frameworks. The results highlight the importance of multi-directional and topological WSS metrics in atherosclerosis related mechanotransduction and near-wall transport processes. Further research is needed to explore the mechanisms of atherosclerosis and longitudinal changes in coronary dynamics.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Yuqing Sun, Bo Zhang, Lianghua Xia
Summary: This study aimed to explore the morphological changes of endothelial cells under different levels of shear stress and find effective evaluation indicators through in vivo and in vitro experiments. The results showed that the size and duration of shear stress can affect the morphology and arrangement of endothelial cells. Traditional cell morphological indicators did not show significant statistical significance, while intercellular space characteristics could be used as effective indicators.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Raghuvir Jonnagiri, Elias Sundstrom, Ephraim Gutmark, Shae Anderson, Amol S. Pednekar, Michael D. Taylor, Justin T. Tretter, Iris Gutmark-Little
Summary: The aim of this study was to assess the association between valve morphology and vortical structures, and examine the impact of valve morphology/orientation on the susceptibility of the aorta to shear stress. The study analyzed data from 6 subjects and used computational fluid dynamics to compare the results with in vivo shear stress data. The findings revealed that tricuspid aortic valves had more vortical flow structures than functionally bicuspid aortic valves, and the location of valve fusion influenced shear stress distribution.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Dressing, Tobias Bormann, Ganna Blazhenets, Nils Schroeter, Lea Walter, Johannes Thurow, Dietrich August, Hanna Hilger, Katarina Stete, Kathrin Gerstacker, Susan Arndt, Alexander Rau, Horst Urbach, Siegbert Rieg, Dirk Wagner, Cornelius Weiller, Philipp T. Meyer, Jonas A. Hosp
Summary: During the long-term phase after COVID-19 infection, patients may experience cognitive deficits and fatigue. In this study, cognitive testing and brain glucose metabolism imaging showed minor impairments in cognitive domains and no distinct pathological changes. This differs from previous findings in subacute COVID-19 patients and may be related to the high prevalence of fatigue.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Martina Conterno, Dorothee Kuemmerer, Andrea Dressing, Volkmar Glauche, Horst Urbach, Cornelius Weiller, Michel Rijntjes
Summary: The study found that speech apraxia and oral apraxia often co-occur, predominantly associated with insular lesions, while isolated speech apraxia is linked to frontal lesions and isolated oral apraxia is related to temporoparietal or striatocapsular region lesions.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Letter
Clinical Neurology
Cornelius Weiller, Volkmar Glauche, Michel Rijntjes
Article
Cardiac & Cardiovascular Systems
Anna Kopczak, Andreas Schindler, Dominik Sepp, Anna Bayer-Karpinska, Rainer Malik, Mia L. Koch, Julia Zeller, Christoph Strecker, Daniel Janowitz, Frank A. Wollenweber, Johann-Martin Hempel, Tobias Boeckh-Behrens, Clemens C. Cyran, Andreas Helck, Andreas Harloff, Ulf Ziemann, Sven Poli, Holger Poppert, Tobias Saam, Martin Dichgans
Summary: Complicated nonstenosing carotid artery plaques (CAPs) are an underestimated cause of stroke. This study aimed to determine the association between complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) and recurrent ischemic stroke or transient ischemic attack (TIA). The study found that patients with icCAP had a higher frequency of recurrent events, and a ruptured fibrous cap and intraplaque hemorrhage were significantly associated with an increased risk of recurrence.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Stefan Brendlin, Isabel Molwitz, Thekla Helene Oechtering, Joerg Barkhausen, Alex Frydrychowicz, Tanja Sulkowski, Maren Friederike Balks, Michael Buchholz, Stefan Lohwasser, Martin Voelker, Olaf Goldschmidt, Anja Johenning, Sabine Schlender, Christian Paulus, Gerald Antoch, Sabine Dettmer, Bettina Baessler, David Maintz, Daniel Pinto dos Santos, Thomas J. Vogl, Elke Hattingen, Dietrich Stoevesandt, Sebastian Reinartz, Corinna Storz, Katharina Mueller-Peltzer, Fabian Bamberg, Fabian Rengier, Meike Weis, Anne Frisch, Nienke Lynn Hansen, Manuel Kolb, Michael Maurer, Konstantin Nikolaou, Saif Afat, Ahmed E. Othman
Summary: During the pandemic, German-speaking universities implemented CoRad-19 in their curriculum and saw significant learning effects. Participants showed high acceptance of e-learning, especially regarding radiology as a suitable subject for digital teaching.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2022)
Article
Clinical Neurology
Jonas A. Hosp, Andrea Dressing, Anika Engesser, Volkmar Glauche, Dorothee Kummerer, Ema B. Vaidelyte, Mariachristina Musso, Michel Rijntjes, Cornelius Weiller
Summary: This study explores the role of the dopaminergic ventral tegmental midbrain nuclei-motor cortex (VTMC) tract in post-stroke recovery. The study found that both the VTMC tract and the corticospinal tract (CST) degenerate after stroke, but only the degeneration of the VTMC tract is associated with lesion size. Regression analysis showed that changes in VTMC tract integrity are more strongly related to independence in daily activities, upper limb motor impairment, and cortical symptoms compared to CST, which is mainly associated with the degree of hemiparesis.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Mariacristina Musso, Eckart Altenmueller, Marco Reisert, Jonas Hosp, Ralf Schwarzwald, Bettina Blank, Julian Horn, Volkmar Glauche, Christoph Kaller, Cornelius Weiller, Martin Schumacher
Summary: Conducting is a well-structured system used to convey information about the rhythm and dynamic of a musical piece. Conductors communicate the musical tempo to the orchestra, creating a unified and expressive musical gestalt. This study found that conducting activates specific regions of the brain, including the supplementary and premotor cortex, superior temporal gyrus, and Broca's area, which are involved in sensorimotor mapping and language processing.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Editorial Material
Clinical Neurology
Cornelius Weiller, Michel Rijntjes
Article
Clinical Neurology
Nils Schroeter, Antonia Weiller, Michel Rijntjes, Andreas Harloff, Horst Urbach, Juraj Kukolja, Juergen Bardutzky, Cornelius Weiller, Lena-Alexandra Beume
Summary: Telemedicine plays an important role in emergency neurology, and head and/or gaze deviation can serve as a reliable biomarker for ischemic stroke and large vessel occlusions (LVOs), making it easier to assess.
JOURNAL OF NEUROLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Adrienne E. Campbell-Washburn, Kathryn E. Keenan, Peng Hu, John P. Mugler, Krishna S. Nayak, Andrew G. Webb, Johnes Obungoloch, Kevin N. Sheth, Juergen Hennig, Matthew S. Rosen, Najat Salameh, Daniel K. Sodickson, Joel M. Stein, Jose P. Marques, Orlando P. Simonetti
Summary: The first ISMRM Workshop on Low-Field MRI was held virtually in March 2022, discussing recent advancements in low field MRI technology and its clinical applications. With 368 registrants from 24 countries, the workshop included invited talks, abstract presentations, panel discussions, and live scanner demonstrations. The workshop emphasized the potential of low-field MRI in expanding MRI usage through cost reduction, portability, and ease of installation, as well as the challenges in overcoming SNR limitations and establishing clinical value.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Nils Schroeter, Tobias Bormann, Michel Rijntjes, Ganna Blazhenets, Raissa Berti, Bastian E. A. Sajonz, Horst Urbach, Cornelius Weiller, Philipp T. Meyer, Alexander Rau, Lars Frings
Summary: This study suggests that microangiopathic white matter lesions do not have a significant impact on neurocognitive performance in Parkinson's disease, while neuronal dysfunction does.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Juergen Hennig
Summary: The paper details the evolution of low-field MRI from its inception to present day, focusing on the differences in research environments. In the early 90s, the lack of reasonable means to compensate for the difference in signal-to-noise ratio between 0.5 and 1.5 T resulted in the disappearance of low-field systems. However, advancements in hardware, RF receiver systems, faster gradients, flexible sampling schemes, and the integration of AI have made low-field MRI a clinically viable supplement. Additionally, ultralow-field MRI with magnets around 0.05 T has emerged as an endeavor to bring MRI to underserved communities.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Rau, Nils Schroeter, Michel Rijntjes, Fabian Bamberg, Wolfgang H. H. Jost, Maxim Zaitsev, Cornelius Weiller, Stephan Rau, Horst Urbach, Marco Reisert, Maximilian F. F. Russe
Summary: This study compared the performance of a Deep Neural Patchwork (DNP) with other established segmentation algorithms in accurately delineating atrophic structures in multiple system atrophy (MSA), Parkinson's disease (PD), and healthy controls. The results showed that DNP had significantly better performance in delineating the putamen compared to other algorithms, and it also demonstrated superior diagnostic accuracy in distinguishing MSA, PD, and healthy controls.
EUROPEAN RADIOLOGY
(2023)
Article
Neuroimaging
E. Kellner, M. Reisert, A. Rau, J. Hosp, T. Demerath, C. Weiller, H. Urbach
Summary: Diffusion microstructure imaging was applied to acute ischemic stroke, revealing changes in intra-axonal compartment volume fraction and diffusivity. DMI metrics showed improved performance in infarct core delineation compared to conventional ADC-derived segmentation.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Mariacristina Musso, David Huebner, Sarah Schwarzkopf, Maria Bernodusson, Pierre LeVan, Cornelius Weiller, Michael Tangermann
Summary: The authors describe a novel language training method for chronic stroke patients with aphasia. This method uses EEG technology to provide feedback and help patients process language stimuli appropriately, resulting in medium to large improvements in language ability. This brain-computer interface-based language training approach has significant potential for rehabilitation.
BRAIN COMMUNICATIONS
(2022)