Article
Cardiac & Cardiovascular Systems
Martina C. de Knegt, Alexia Rossi, Steffen E. Petersen, Andrew Wragg, Ruhaid Khurram, Mark Westwood, Bunny Saberwal, Anthony Mathur, Koen Nieman, Fabian Bamberg, Magnus T. Jensen, Francesca Pugliese
Summary: This study aimed to evaluate the diagnostic performance and incremental value of qualitative CMR perfusion and quantitative CT perfusion, when used in combination with CCTA, for the diagnosis of haemodynamically significant CAD. The results showed that visual CMR perfusion and relative CT-MBF outperformed visual CT perfusion, and combining these modalities with CCTA improved discrimination in diagnosing haemodynamically significant CAD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ronny R. Buechel, Domenico Ciancone, Adam Bakula, Elia von Felten, Gian-Andrea Schmidt, Dimitri Patriki, Christoph Graeni, Andreas Wahl, Robert Manka, Bettina Heidecker, Dominik C. Benz, Andreas A. Giannopoulos, Aju P. Pazhenkottil, Philipp A. Kaufmann
Summary: This study aimed to evaluate the effect of myocardial inflammation on myocardial blood flow (MBF) using 13N-ammonia positron emission tomography myocardial perfusion imaging (PET-MPI) in patients with a history of myocarditis. The results showed that patients with healed myocarditis had higher stress MBF, myocardial flow reserve (MFR), and ammonia washout compared to remote segments. Additionally, some patients were diagnosed with myocardial scar by PET-MPI without corresponding late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR).
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Louise A. E. Brown, Gaurav S. Gulsin, Sebastian C. Onciul, David A. Broadbent, Jian L. Yeo, Alice L. Wood, Christopher E. D. Saunderson, Arka Das, Nicholas Jex, Amrit Chowdhary, Sharmaine Thirunavukarasu, Noor Sharrack, Kristopher D. Knott, Eylem Levelt, Peter P. Swoboda, Hui Xue, John P. Greenwood, James C. Moon, David Adlam, Gerry P. McCann, Peter Kellman, Sven Plein
Summary: This study aimed to establish sex- and age-specific normal values for myocardial blood flow (MBF) in healthy volunteers. The results showed differences in MBF between males and females, and a decrease in MBF and myocardial perfusion reserve with advancing age.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Tanja Kero, Edvin Johansson, Mathias Engstrom, Kai M. Eggers, Lars Johansson, Hakan Ahlstrom, Mark Lubberink
Summary: The study evaluated the quantitative accuracy of cardiac perfusion measurements using dynamic contrast-enhanced MRI with simultaneous O-15-water PET as reference on a fully integrated PET-MR scanner. The results showed strong correlation but only moderate agreement between the two modalities, indicating that MRI-based quantitative MBF measurements are not yet ready for clinical use.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qi Huang, Ye Tian, Jason Mendes, Ravi Ranjan, Ganesh Adluru, Edward DiBella
Summary: The purpose of this study was to evaluate a new 2D simultaneous multi-slice myocardial perfusion acquisition and compare it directly to a published quantitative 3D stack-of-stars acquisition. The results showed that the alternating beat acquisition method resulted in comparable perfusion values for both the 2D SMS and 3D SoS sequences.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Biotechnology & Applied Microbiology
Marije E. Kamphuis, Henny Kuipers, H. Remco Liefers, Jan van Es, Frank F. J. Simonis, Marcel J. W. Greuter, Cornelis H. Slump, Riemer H. J. A. Slart
Summary: This study explores the application of a dedicated cardiac flow phantom for contrast measurements in multimodal myocardial perfusion imaging. Using clinical hardware and software, the phantom successfully completed quantitative measurements, showcasing its potential in multimodal imaging.
BIOENGINEERING-BASEL
(2022)
Review
Cardiac & Cardiovascular Systems
Russell Franks, Sven Plein, Amedeo Chiribiri
Summary: Dynamic contrast enhanced CMR perfusion imaging is a reliable non-invasive tool for the evaluation and risk stratification of patients with coronary artery disease. It offers high spatial and temporal resolution, and does not involve ionizing radiation, making it recommended by international guidelines.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Giulia Elena Mandoli, Flavio D'Ascenzi, Giulia Vinco, Giovanni Benfari, Fabrizio Ricci, Marta Focardi, Luna Cavigli, Maria Concetta Pastore, Nicolo Sisti, Oreste De Vivo, Ciro Santoro, Sergio Mondillo, Matteo Cameli
Summary: Advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, providing valuable insights into specific disease processes. The diagnostic accuracy, incremental yield, and prognostic value of speckle tracking echocardiography, late gadolinium enhancement, and parametric mapping modules by cardiac magnetic resonance and cardiac computed tomography have been validated against tissue samples, offering relevant clinical information to cardiologists.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Amit R. Patel, Michael Salerno, Raymond Y. Kwong, Amita Singh, Bobak Heydari, Christopher M. Kramer
Summary: Stress cardiovascular magnetic resonance imaging (CMR) is a cost-effective and noninvasive method that accurately evaluates myocardial ischemia, viability, and function. It has been shown to have higher diagnostic sensitivity compared to other imaging modalities, making it particularly valuable for patients with suspected or known cardiovascular disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-hai Zhao, Wei-feng Guo, Zhi-feng Yao, Shan Yang, Hong Yun, Yin-yin Chen, Tong-tong Han, Xiao-yue Zhou, Cai-xia Fu, Meng-su Zeng, Chen-guang Li, Cui-zhen Pan, Hang Jin
Summary: In this study, a fully automated pixel-wise post-processing framework was used to evaluate quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). The study aimed to assess the additional value of coronary magnetic resonance angiography (CMRA) in the diagnostic performance of fully automated pixel-wise quantitative CMR-MPI for detecting hemodynamically significant coronary artery disease (CAD). The results showed that the fully automated pixel-wise quantitative CMR-MPI can accurately detect hemodynamically significant CAD, but the integration of CMRA did not provide significantly additive value.
EUROPEAN RADIOLOGY
(2023)
Article
Computer Science, Information Systems
Matthew Jacobs, Mitchel Benovoy, Lin-Ching Chang, David Corcoran, Colin Berry, Andrew E. Arai, Li-Yueh Hsu
Summary: A fully automatic method of segmenting left ventricular myocardium from MBF pixel maps was developed and validated on a dataset of clinical CMR perfusion studies. The automated segmentation method showed high consistency and accuracy when compared to manually defined reference standards, with good correlation and minimal bias in sector-wise MBF and MPR values. This validated method has the potential to aid in quantitative assessment of myocardial perfusion in CMR studies.
Article
Medicine, General & Internal
Jun Ye, Wenxia Zong, Xing Wu, Xiaonan Shao, Yue Wu
Summary: The study evaluated the value of feature-tracking cardiac magnetic resonance (FT-CMR) imaging in the quantitative assessment of acute myocardial infarction (AMI). The results demonstrated that FT-CMR could effectively evaluate myocardial strain parameters in AMI patients and predict the occurrence of ST-elevation myocardial infarction (STEMI). Therefore, FT-CMR has a high diagnostic value and can be helpful for the prevention and intervention of ventricular remodeling after myocardial infarctions.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew E. Arai, Jeanette Schulz-Menger, Dipan J. Shah, Yuchi Han, W. Patricia Bandettini, Arun Abraham, Pamela K. Woodard, Joseph B. Selvanayagam, Christian Hamilton-Craig, Ru-San Tan, James Carr, Lynette Teo, Christopher M. Kramer, Bernd J. Wintersperger, Mukesh G. Harisinghani, Scott D. Flamm, Matthias G. Friedrich, Igor Klem, Subha Raman, Daniel Haverstock, Zheyu Liu, Guenther Brueggenwerth, Marta Santiuste, Daniel S. Berman, Dudley J. Pennell
Summary: The study demonstrates that vasodilator stress perfusion cardiovascular magnetic resonance (CMR) performed with gadobutrol has superior diagnostic accuracy for the diagnosis and exclusion of significant coronary artery disease (CAD) compared to gated single-photon emission computed tomography (SPECT).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pei-Lun Han, Xue-Ming Li, Li Jiang, Wei-Feng Yan, Ying-Kun Guo, Yuan Li, Kang Li, Zhi-Gang Yang
Summary: This study investigated the impact of obesity on myocardial microcirculation and left ventricular deformation in hypertensive patients using cardiac magnetic resonance. The findings suggest that obesity has adverse effects on microvascular changes and subclinical left ventricular dysfunction in hypertension, and body mass index is independently associated with both myocardial perfusion and left ventricular deformation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ronald Mooiweer, Radhouene Neji, Sarah McElroy, Muhummad Sohaib Nazir, Reza Razavi, Amedeo Chiribiri, Sebastien Roujol
Summary: A fast respiratory navigator called fastNAV was developed for cardiac MR perfusion imaging, showing improved image quality and reduced heart displacement in real-time respiratory tracking.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael Hock, Maxim Terekhov, Maria Roxana Stefanescu, David Lohr, Stefan Herz, Theresa Reiter, Markus Ankenbrand, Aleksander Kosmala, Tobias Gassenmaier, Christoph Juchem, Laura Maria Schreiber
Summary: Inhomogeneities of the static magnetic B(0) field in cardiac MRI at ultrahigh field lead to signal loss and image distortions. A methodology for spherical harmonics shimming of the B(0) field within the human myocardium is proposed, using third-order spherical harmonics terms for better results. Challenges in state-of-the-art B(0) shimming of the human heart at 7T were described, with cardiac phase-specific shimming strategies found to be superior.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Markus J. Ankenbrand, Liliia Shainberg, Michael Hock, David Lohr, Laura M. Schreiber
Summary: This paper introduces a method for interpreting segmentation models called sensitivity analysis. By modifying the model input in a controlled manner and evaluating the effect of these modifications on the model output, this method can reveal insights into the model's sensitivity to changes and the importance of specific features in segmentation performance. The authors demonstrate the applicability of this method for practical questions in segmentation models, particularly in the field of cardiac magnetic resonance imaging, using an open-source Python library.
BMC MEDICAL IMAGING
(2021)
Article
Medicine, General & Internal
Julia Masomi-Bornwasser, Axel Heimann, Christian Schneider, Tristan Klodt, Hammoud Elmehdawi, Andrea Kronfeld, Harald Krenzlin, Yasemin Tanyildizi, Karl-Friedrich Kreitner, Oliver Kempski, Clemens Sommer, Florian Ringel, Naureen Keric
Summary: The combined therapy of drainage, rtPA, and ultrasound is a safe and effective technique for hematoma reduction and protection of the perihematomal tissue in regard to ultra-early effects, leading to a significantly higher hematoma reduction compared to other treatment groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
L. A. R. Righesso, M. Terekhov, H. Goetz, M. Ackermann, T. Emrich, L. M. Schreiber, W. E. G. Mueller, J. Jung, J. P. Rojas, B. Al-Nawas
Summary: The study found that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to monitor neovascularization, but does not predict bone regeneration. Blood perfusion showed potential value in evaluating the efficacy of osteoplastic materials in the experiment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Markus Johannes Ankenbrand, David Lohr, Wiebke Schloetelburg, Theresa Reiter, Tobias Wech, Laura Maria Schreiber
Summary: This study demonstrates the benefits of transfer learning for cardiac cine image segmentation and provides practical guidelines for researchers planning transfer learning projects in cardiac MRI.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biophysics
Irvin Teh, William A. R. Romero, Jordan Boyle, Jaume Coll-Font, Erica Dall'Armellina, Daniel B. Ennis, Pedro F. Ferreira, Prateek Kalra, Arunark Kolipaka, Sebastian Kozerke, David Lohr, Francois-Pierre Mongeon, Kevin Moulin, Christopher Nguyen, Sonia Nielles-Vallespin, Brian Raterman, Laura M. Schreiber, Andrew D. Scott, David E. Sosnovik, Christian T. Stoeck, Cyril Tous, Elizabeth M. Tunnicliffe, Andreas M. Weng, Pierre Croisille, Magalie Viallon, Jurgen E. Schneider
Summary: Cardiac diffusion tensor imaging (DTI) is an emerging technique for characterizing myocardial microstructure. This study validated and standardized state-of-the-art pulse sequences for cardiac DTI among 10 international centers. The results showed that custom sequences for cardiac DTI provide accurate, precise, repeatable, and reproducible measurements.
NMR IN BIOMEDICINE
(2022)
Article
Biophysics
Ibrahim A. Elabyad, Maxim Terekhov, David Lohr, Maya Bille, Michael Hock, Laura M. Schreiber
Summary: A dedicated dipole antenna array was designed to improve parallel transmit and receive performance for cardiac MRI in pigs at 7 T. The array demonstrated improved decoupling and additional degrees of freedom for B shimming. Experimental results showed good transmit and receive characteristics of the novel array design in imaging experiments conducted in pig hearts.
NMR IN BIOMEDICINE
(2022)
Article
Biophysics
Yun Shang, Sebastian Theilenberg, Maxim Terekhov, Wolfram Mattar, Boyu Peng, Sachin R. Jambawalikar, Laura M. Schreiber, Christoph Juchem
Summary: This study used clinical CT images to simulate the B-0 conditions in the human heart at high spatial resolution, enabling the development of subject- and population-specific B-0 shim strategies.
NMR IN BIOMEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
David Lohr, Arne Thiele, Max Stahnke, Vera Braun, Elia Smeir, Joachim Spranger, Sebastian Brachs, Robert Klopfleisch, Anna Foryst-Ludwig, Laura M. Schreiber, Ulrich Kintscher, Niklas Beyhoff
Summary: This study aimed to characterize myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction. The results showed that a high-fat diet induced alterations in myocardial diffusion properties, but did not lead to remodeling of the three-dimensional myofiber arrangement of the left ventricle. Obese mice exhibited reduced diastolic function and longitudinal strain, emphasizing the need for further investigation into the significance of regional patterns in obesity-related cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Stefan Herz, Maria R. Stefanescu, David Lohr, Patrick Vogel, Aleksander Kosmala, Maxim Terekhov, Andreas M. Weng, Jan-Peter Grunz, Thorsten A. Bley, Laura M. Schreiber
Summary: This study investigates the effects of B-1-shimming and RF parallel transmission on the visualization and quantification of coronary artery stenosis using 7 Tesla MRI. The results demonstrate that B-1-shimming and pTX significantly improve image homogeneity and provide more accurate MR image analysis.
Article
Cardiac & Cardiovascular Systems
Laura M. Schreiber, David Lohr, Steffen Baltes, Ulrich Vogel, Ibrahim A. Elabyad, Maya Bille, Theresa Reiter, Aleksander Kosmala, Tobias Gassenmaier, Maria R. Stefanescu, Alena Kollmann, Julia Aures, Florian Schnitter, Mihaela Pali, Yuichiro Ueda, Tatiana Williams, Martin Christa, Ulrich Hofmann, Wolfgang Bauer, Brenda Gerull, Alma Zernecke, Sueleyman Erguen, Maxim Terekhov
Summary: A key step in translational cardiovascular research is the use of large animal models to understand physiology, test drugs, and perform studies unethical in humans. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is increasingly used for imaging the heart, offering better image quality and information content. This study presents a solution to the dual use problem of UHF-MRI systems, demonstrating its potential in translational cardiovascular research across different scales.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Shang, Sebastian Theilenberg, Martin Gajdosik, Laura M. Schreiber, Christoph Juchem
Summary: This study aims to simulate and validate the B-0 distribution in the human heart across the cardiac cycle using structural MRI images. Cardiac phase-specific B-0 field maps were acquired and simulated based on tissue masks created from structural images and anatomical images. The results show a strong correlation between the simulations and in vivo measurements.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Lei Li, Fuping Wu, Sihan Wang, Xinzhe Luo, Carlos Martin-Isla, Shuwei Zhai, Jianpeng Zhang, Yanfei Liu, Zhen Zhang, Markus J. Ankenbrand, Haochuan Jiang, Xiaoran Zhang, Linhong Wang, Tewodros Weldebirhan Arega, Elif Altunok, Zhou Zhao, Feiyan Li, Jun Ma, Xiaoping Yang, Elodie Puybareau, Ilkay Oksuz, Stephanie Bricq, Weisheng Li, Kumaradevan Punithakumar, Sotirios A. Tsaftaris, Laura M. Schreiber, Mingjing Yang, Guocai Liu, Yong Xia, Guotai Wang, Sergio Escalera, Xiahai Zhuang
Summary: Assessment of myocardial viability is crucial in myocardial infarction diagnosis and treatment. This study introduces a new task of myocardial pathology segmentation (MyoPS) using three-sequence cardiac magnetic resonance images. The challenge provided 45 paired and pre-aligned CMR images for algorithms to segment pathology. The average Dice scores for myocardial scars and edema were 0.614 +/- 0.231 and 0.644 +/- 0.153, respectively.
MEDICAL IMAGE ANALYSIS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mark E. Ladd, Harald H. Quick, Oliver Speck, Michael Bock, Arnd Doerfler, Michael Forsting, Juergen Hennig, Bernd Ittermann, Harald E. Moeller, Armin M. Nagel, Thoralf Niendorf, Stefan Remy, Tobias Schaeffter, Klaus Scheffler, Heinz-Peter Schlemmer, Sebastian Schmitter, Laura Schreiber, N. Jon Shah, Tony Stoecker, Michael Uder, Arno Villringer, Nikolaus Weiskopf, Moritz Zaiss, Maxim Zaitsev
Summary: Multiple sites in Germany operate human MRI systems at 7 Tesla or 9.4 Tesla. The German Ultrahigh Field Imaging (GUFI) network was established in 2013 to facilitate research cooperation and make this technology available to a larger community of researchers and clinicians worldwide. This paper summarizes the history, current status, motivation, and challenges of pursuing MRI at higher magnetic field strengths, focusing on the perspective in Germany.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maxim Terekhov, Ibrahim A. A. Elabyad, David Lohr, Ulrich Hofmann, Laura M. M. Schreiber
Summary: In this study, a custom-built, multiple-element transceiver array was used for high-resolution imaging of excised hearts. The array demonstrated high efficiency in parallel transmit and receive, and successfully obtained ultra-high-resolution images and myocardial fiber orientation information.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)