Article
Radiology, Nuclear Medicine & Medical Imaging
Dion G. Thomas, Petrik Galvosas, Yu-Chieh Tzeng, Freya G. Harrison, Mary J. Berry, Paul D. Teal, Graham A. Wright, Sergei Obruchkov
Summary: This study explores the feasibility of blood oximetry at low magnetic fields and shows that despite small, the change in blood T-2 due to oxygenation is detectable at low B-0 fields. The data measured at low fields are also in agreement with theoretical models for the oxy-deoxy T-2 effect.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilana R. Leppert, Daniel A. Andrews, Jennifer S. W. Campbell, Daniel J. Park, G. Bruce Pike, Jonathan R. Polimeni, Christine L. Tardif
Summary: The study demonstrates the feasibility of measuring tract-specific T-1 values in the whole brain using slice-shuffled IR-DWI at 3T, showing accurate and precise results through simulations and experiments. This technique has the potential to improve the characterization of specific tracts involved in neurodevelopment, aging, and demyelinating disorders.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jana Hutter, Alison Ho, Laurence H. Jackson, Paddy J. Slator, Lucy C. Chappell, Joseph V. Hajnal, Mary A. Rutherford
Summary: The study introduces a new method for jointly assessing microstructural and molecular properties of the human placenta in vivo. It demonstrates the ability to obtain robust and fast T1-ADC measurements, with initial evidence in cohorts of healthy pregnancies and those affected by pre-eclampsia. Future work will focus on expanding the field-of-view using multi-band acceleration techniques and larger patient groups.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Muhamed Barakovic, Chantal M. W. Tax, Umesh Rudrapatna, Maxime Chamberland, Jonathan Rafael-Patino, Cristina Granziera, Jean-Philippe Thiran, Alessandro Daducci, Erick J. Canales-Rodriguez, Derek K. Jones
Summary: A novel framework named COMMIT-T-2 is proposed to estimate multiple intra-axonal T-2 values within a voxel using tractography-based spatial regularization with diffusion-relaxometry data. Unlike previous methods, COMMIT-T-2 can recover specific T-2 values for each unique fiber population passing through the voxel.
Article
Biochemistry & Molecular Biology
Steffen Merz, Jie Wang, Petrik Galvosas, Josef Granwehr
Summary: This study investigates the dynamics of ILs in carbon black and confirms the relationship between alkyl length and cation aggregation behavior, providing important insights for optimizing IL-based electrolytes. A different aggregation behavior was found for ILs in CB compared to neat IL, highlighting the potential use of the porous electrode surface as an additional parameter for optimization. The suitability of MAS for studying this class of samples was also critically discussed.
Article
Surgery
Alejandro Zulbaran-Rojas, Rasha O. Bara, Myeounggon Lee, Areli Flores-Camargo, Ramkinker Mishra, Sebastian Winocour, Alastair Thompson, Bijan Najafi
Summary: This study explored the feasibility of using continuous diffusion of oxygen (CDO) in bilateral reduction mammoplasty (BRM) procedures. The results showed that CDO may enhance breast tissue oxygenation in a proper wound environment. However, it is unclear whether CDO leads to decreased wound dehiscence. This study demonstrated the reproducibility for larger randomized trials.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biochemical Research Methods
Michael M. B. Ross, Grant R. Wilbur, Prisciliano F. de J. Cano Barrita, Bruce J. Balcom
Summary: The Proteus magnet is a new portable magnet designed for a wide range of MR measurements, especially for H-1 measurements of liquids, fabricated from low-cost commercial NdFeB magnets. Its performance was evaluated through a series of measurements.
JOURNAL OF MAGNETIC RESONANCE
(2021)
Article
Materials Science, Multidisciplinary
Patrick Bottke, Katharina Hogrefe, Julia Kohl, Suliman Nakhal, Alexandra Wilkening, Paul Heitjans, Martin Lerch, H. Martin R. Wilkening
Summary: The visualization of atomic or ionic jump processes on a nanometer length scale is important for understanding diffusion pathways in solid electrolytes. This study used high-resolution 6Li nuclear magnetic resonance (NMR) spectroscopy to investigate Li+ exchange processes in Li3VF6. The results confirmed the preferred diffusion pathways and provided further insights into ion dynamics between corner-shared Li-bearing polyhedra.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Martin Kunth, Leif Schroeder
Summary: The study simplifies the behavior of spin-spin relaxation rates in different chemical environments using hyperpolarized Xe-129 as a reporter ligand. It was found that even in a diamagnetic system, detection of analyte concentrations can be achieved through large Larmor frequency jumps. This approach provides a way to measure exchange rates even in systems where direct measurements are challenging.
Article
Chemistry, Inorganic & Nuclear
Yongqing Wang, Jiangshuai Chen, Keli Liu, Mingyuan Wang, Dongxing Song, Ke Wang
Summary: Doping transition metal elements in La2NiO4+delta compounds at the Ni site significantly reduces the formation and migration energies of interstitial oxygen, enabling the screening of promising cathode materials for solid oxide fuel cells. Fe-doped structures of x=0.25, Ru-doped structures of x=0.25 and x=0.375, Rh-doped structures of x=0.50, and Pd-doped structures of x=0.375 and x=0.50 exhibit favorable interstitial oxygen formation energy and migration barrier. Additionally, doping enhances electron conductivity in La2NiO4+delta. This work provides a theoretical guideline for the optimization and design of doped La2NiO4+delta-based cathode materials.
INORGANIC CHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter J. Niedbalski, Chase S. Hall, Mario Castro, Rachel L. Eddy, Jonathan H. Rayment, Sarah Svenningsen, Grace Parraga, Brandon Zanette, Giles E. Santyr, Robert P. Thomen, Neil J. Stewart, Guilhem J. Collier, Ho-Fung Chan, Jim M. Wild, Sean B. Fain, G. Wilson Miller, Jaime F. Mata, John P. Mugler, Bastiaan Driehuys, Matthew M. Willmering, Zackary Cleveland, Jason C. Woods
Summary: Standard protocols for harmonizing methods of image acquisition in HP Xe-129 MRI have been recommended to promote consistency in imaging studies and facilitate wider adoption of HP Xe-129 MRI in translational research, multi-site trials, and clinical practice. Recommendations have been made for the most common HP gas MRI techniques and Xe-129 dose volumes to enhance imaging study consistency. Additionally, a roadmap for technical developments has been provided to further improve image quality and efficiency in HP Xe-129 MRI.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Physics, Applied
Armin Afrough, Florea Marica, Bryce MacMillan, Bruce J. Balcom
Summary: Non-ground eigenvalues in magnetic resonance relaxation measurements provide information about the pore size and surface relaxivity of porous media, without the need for calibration through independent measurements. Analysis of non-ground eigenvalues in T1-T2 measurements can yield consistent results with other measurement methods.
PHYSICAL REVIEW APPLIED
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Indira Laothamatas, Haitham Al Mubarak, Arthi Reddy, Rebecca Wax, Ketan Badani, Bachir Taouli, Octavia Bane, Sara Lewis
Summary: Solid renal masses (SRMs) include both benign and malignant masses, with renal cell carcinoma (RCC) being the most common malignant SRM. Noninvasively diagnosing and characterizing RCCs is important due to variability in clinical behavior and management options. Cross-sectional imaging, such as magnetic resonance imaging (MRI), can provide insight into tumor biology using multiparametric (mp) MRI techniques. This review discusses mpMRI methods and their roles in assessing SRMs, with the goal of enabling personalized management in the era of precision medicine.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Engineering, Biomedical
Bingbing Cheng, Chenchen Bing, Tak Ho Chu, Saud Alzahrani, Samuel Pichardo, G. Bruce Pike
Summary: The study demonstrated the feasibility and safety of achieving precise brain hyperthermia at significantly reduced power and simultaneous localized blood-brain barrier opening through transcranial MR-guided focused ultrasound and microbubbles, providing a new synergistic method for brain drug delivery with clinical translation potential.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Clinical Neurology
Andrew E. Beaudin, Cheryl R. McCreary, Erin L. Mazerolle, Myrlene Gee, Breni Sharma, Arsenije Subotic, Angela M. Zwiers, Emily Cox, Krista Nelles, Anna Charlton, Richard Frayne, Zahinoor Ismail, Christian Beaulieu, Glen C. Jickling, Richard M. Camicioli, G. Bruce Pike, Eric E. Smith
Summary: This study found that reduced cerebrovascular reactivity is a core feature of cerebral amyloid angiopathy (CAA), and it is associated with white matter hyperintensity volume and cognitive function. This finding could provide additional biomarkers for assessing the severity of the disease and cognitive impairment.
Article
Neurosciences
Olayinka Oladosu, Wei-Qiao Liu, Lenora Brown, Bruce G. Pike, Luanne M. Metz, Yunyan Zhang
Summary: This study investigates the differences in brain structure between relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) using diffusion magnetic resonance imaging (MRI) and image texture analysis. The study finds that diffusion and texture features can differentiate between RRMS and SPMS, with the extent and number of lesions significantly increased in SPMS. The results contribute to a better understanding of the pathological mechanisms in multiple sclerosis.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Arash Aghamohammadi-Sereshki, Carly A. McMorris, W. Ben Gibbard, Christina Tortorelli, G. Bruce Pike, Catherine Lebel
Summary: Prenatal alcohol exposure may affect the neurobehavioral development of the pregenual ACC and anterior MCC in children and adolescents, leading to emotional and behavioral problems.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ian J. Tagge, Ilana R. Leppert, Dumitru Fetco, Jennifer Sw Campbell, David A. Rudko, Robert A. Brown, Nikola Stikov, G. Bruce Pike, Paul S. Giacomini, Douglas L. Arnold, Sridar Narayanan
Summary: This study investigates the relationship between MRI measures of axonal and myelin volume fractions in normal-appearing white matter (NAWM) and the development of black-hole (BH) and non-BH lesions in people with MS. The results show that pre-lesion abnormalities are associated with worse long-term lesion-level outcomes, but no significant pre-lesion abnormalities were found in non-BH lesions.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Oncology
Runze Yang, A. Max Hamilton, Hongfu Sun, Khalil S. Rawji, Susobhan Sarkar, Reza Mirzaei, G. Bruce Pike, V. Wee Yong, Jeff F. Dunn
Summary: This study demonstrates that MRI with USPIO injection can detect therapeutic responses of innate immune stimulating agents, providing a potential imaging technique for monitoring cancer immunotherapies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemical Research Methods
Zahra Hosseinpour, Laura Jonkman, Olayinka Oladosu, Glen Pridham, G. Bruce Pike, Matilde Inglese, Jeroen J. Geurts, Yunyan Zhang
Summary: This study developed a new texture analysis and machine learning method that can better identify and classify pathology subtypes in multiple sclerosis.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Neurosciences
Seyedmohammad Shams, Prokopis Prokopiou, Azin Esmaelbeigi, Georgios D. Mitsis, J. Jean Chen
Summary: Conventionally, cerebrovascular reactivity (CVR) is estimated as the amplitude of the hemodynamic response to vascular stimuli, most commonly carbon dioxide (CO2). While the CVR amplitude has established clinical utility, the temporal characteristics of CVR (dCVR) have been increasingly explored and may yield even more pathology-sensitive parameters. This work compares several model-based deconvolution approaches for estimating the CO2 response function and proposes a novel simulation framework to aid the comparison. The findings suggest that model-based methods can accurately estimate dCVR even amidst high noise and provide a quantitative basis for methodological choices.
Article
Neurosciences
Abdoljalil Addeh, Fernando Vega, Prathistith Raj Medi, Rebecca J. Williams, G. Bruce Pike, M. Ethan MacDonald
Summary: A deep learning-based method is proposed to directly reconstruct respiratory variation waveforms from BOLD fMRI data in pediatric participants without the need for respiratory measurement devices. A convolutional neural network (CNN) was trained and evaluated using the Lifespan Human Connectome Project in Development (HCP-D) dataset. The results demonstrate that the CNN can capture informative features from the BOLD signal and accurately reconstruct respiratory variation timeseries, especially during prominent respiratory events.
Article
Multidisciplinary Sciences
Qing Wang, Meshal Aljassar, Nikhil Bhagwat, Yashar Zeighami, Alan C. Evans, Alain Dagher, G. Bruce Pike, Abbas F. Sadikot, Jean-Baptiste Poline
Summary: This study analyzed the structural differences in the cerebellum in ET using a large dataset and found that the results varied with different methods, suggesting that the current estimation of cerebellar involvement in ET may be overemphasized in MRI studies. It highlights the importance of methods sensitivity analysis on results interpretation.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Catherine A. Swytink-Binnema, Conrad P. Rockel, Davide Martino, Sean P. Dukelow, G. Bruce Pike, Zelma H. T. Kiss
Summary: Magnetic resonance-guided focused-ultrasound (MRgFUS) thalamotomy is an effective treatment for essential and other tremors. This study used the Kinarm exoskeleton robot to quantitatively measure the effects of MRgFUS on proprioception and limb use in patients with essential tremor, and found that MRgFUS did not degrade proprioception but altered limb preference.
MOVEMENT DISORDERS
(2023)
Article
Endocrinology & Metabolism
Arjun Patel, Jordan A. A. Chad, J. Jean Chen
Summary: This study explores the relationship between obesity and brain health, specifically focusing on the differences between males and females. The findings suggest that there are sex differences in the association between adiposity and intelligence as well as white matter microstructure. This highlights the importance of considering sex-driven differences when studying the impact of obesity on brain degeneration.
Article
Biology
Ford Burles, Rebecca Williams, Lila Berger, G. Bruce Pike, Catherine Lebel, Giuseppe Iaria
Summary: After spaceflight, astronauts experience upward shifting of the brain and redistribution of cerebrospinal fluid. Brain volume changes observed in astronauts are contaminated by preprocessing errors and may not be direct evidence of neuroplastic adaptation. New preprocessing methods or experimental paradigms are needed to resolve this issue in space health research.
Article
Engineering, Biomedical
Carly Pellow, Siyun Li, Sagid Delgado, G. Bruce Pike, Laura Curiel, Samuel Pichardo
Summary: In this study, a single-element biaxially driven ring transducer was applied for the first time in vivo for blood-brain barrier opening in mice, and compared to a conventional single-element highly focused spherical transducer. The opening volume achieved with the biaxial ring transducer was 35% smaller than that achieved with the spherical transducer, while the axial refocusing capability of the biaxial ring transducer resulted in a deeper and larger opening volume. The biaxial ring transducer allowed for more localized and dynamic axial refocusing with a smaller fabrication footprint compared to the spherical transducer.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Clinical Neurology
Catherine A. Swytink-Binnema, Conrad P. Rockel, Davide Martino, Sean P. Dukelow, G. Bruce Pike, Zelma H. T. Kiss
Summary: This study quantitatively measured the effects of MRgFUS on proprioception and limb use. The results suggest that MRgFUS thalamotomy does not degrade proprioception but alters limb preference.
MOVEMENT DISORDERS
(2023)
