Article
Chemistry, Multidisciplinary
Zhiyong Peng, Xiao-Qin Xu, Xu-Qing Wang, Xueliang Shi, Wei Wang, Hai-Bo Yang
Summary: The precise synthesis of novel rotaxane-branched radical dendrimers with multiple TEMPO radicals as termini was successfully achieved. Nanoparticles with a good longitudinal relaxivity were prepared, making them potential candidates for contrast agents in magnetic resonance imaging.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Connor M. Ellis, Daohe Yuan, Ferenc E. Mozes, Jack J. Miller, Jason J. Davis
Summary: Paramagnetically-doped polymer micelles with ionizable poly(acrylic acid) (PAA) block enable high-contrast MR imaging at clinically relevant field strengths with strong pH sensitivity. The reversible switch in polymer strand charge directly affects the local rigidity and rotational correlation time characteristics of the integrated Gd-chelate, resulting in a 50% amplitude switch in positive contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Songbai Zhang, Vega Lloveras, Silvia Lope-Piedrafita, Pilar Calero-Perez, Shuang Wu, Silvia Lope-Piedrafita, Ana Paula Candiota, Jose Vidal-Gancedo
Summary: MRI is a highly required imaging approach for the early diagnosis and follow-up of tumors, especially brain cancer. Organic radicals anchored on a dendrimer macromolecule surface show promising potential as alternatives to traditional Gd-based contrast agents, with similar contrast enhancement effects, lower toxicity, and longer biological stability.
Review
Nanoscience & Nanotechnology
Anna Kastelik-Hryniewiecka, Pawel Jewula, Karolina Bakalorz, Gabriela Kramer-Marek, Nikodem Kuznik
Summary: The demand for hybrid PET/MRI imaging techniques has increased significantly in recent years, driving research into new methods to track multiple molecular targets simultaneously and improve the localization and expression of biochemical markers. Multimodal imaging probes have emerged as powerful tools for enhancing detection sensitivity and accuracy, but only a limited number of bimodal probes have been studied in preclinical models. This article briefly describes the strengths and limitations of PET and MRI modalities, emphasizing the need for the development of multimodal molecularly-targeted agents.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Siavash Iravani, Rajender S. Varma
Summary: Magnetic resonance imaging (MRI) is a widely used noninvasive clinical imaging modality in bio- and nanomedicine, especially for tumor detection and high-quality three-dimensional imaging. The design of efficient nanoscale contrast agents (NCAs) is crucial for specific detection and imaging of tumors. However, there are still challenges to be addressed in the clinical applications of these agents, including nanotoxicology and biosafety issues.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sihan Ma, Lin Wang, Zongjunlin Liu, Xian Luo, Zonglang Zhou, Jun Xie, Yipeng Li, Shuo Cong, Min Zhou, Yang Xu, Guang Ran
Summary: This study successfully synthesized a multi-functional theranostic agent BiNS@NaLnF(4) with excellent imaging and therapeutic effects, providing new insights for synergistic theranostics of tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Emily G. Pedrick, Darryl B. Sneag, Philip G. Colucci, Mylinh Duong, Ek T. Tan
Summary: This pilot study aimed to evaluate the effects of low-dose ferumoxytol on vascular suppression and nerve visualization in 3D brachial plexus MR neurography. The results showed that the use of ferumoxytol significantly improved vascular suppression and nerve visualization compared to imaging without ferumoxytol, indicating its potential clinical application for enhancing imaging quality.
Review
Chemistry, Physical
Huan Zhang, Xiao Li Liu, Hai Ming Fan
Summary: Magnetic resonance imaging (MRI) has revolutionized medical imaging diagnostics. However, the clinical use of Gd-based contrast agents (CAs) still has limitations, making the development of magnetic nanoparticle-based CAs a promising avenue for research.
Article
Materials Science, Biomaterials
Thi Kim Dung Doan, Masakazu Umezawa, Kyohei Okubo, Masao Kamimura, Masayuki Yamaguchi, Hirofumi Fujii, Kohei Soga
Summary: Multimodal imaging, combining over one-thousand-nanometer near-infrared (OTN-NIR) fluorescence and magnetic resonance (MR) imaging, is attractive for biomedical research. In this study, a bimodal OTN-NIR/MRI probe was developed by encapsulating IR-1061 in a gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA) conjugated poly(lactic-co-glycolic acid)-block-poly(ethylene glycol) copolymer (PLGA-b-PEG) micelle at two different locations. The probe structure with Gd-DOTA at the border of PLGA/PEG showed stable fluorescence and signal distribution, indicating enhanced structural stability and performance.
BIOMATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Svetlana Fedorenko, Alexey Stepanov, Olga Bochkova, Kirill Kholin, Irek Nizameev, Alexandra Voloshina, Oksana Tyapkina, Dmitry Samigullin, Sofiya Kleshnina, Bulat Akhmadeev, Alexander Romashchenko, Evgenii Zavjalov, Rustem Amirov, Asiya Mustafina
Summary: The co-doped silica nanoparticles with paramagnetic and luminescent complexes were successfully synthesized. The specific distribution of the paramagnetic complex within the nanoparticles significantly enhanced the magnetic relaxivities compared to those in solutions. The leaching of paramagnetic complex from the shell was minimized by co-doping luminescent complex into the core of the nanoparticles. The co-doped nanoparticles exhibited colloid stability in aqueous solutions, including blood serum. The cytotoxicity, hemoagglutination, and hemolytic activities of the co-doped nanoparticles were suitable for in vivo studies.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Physiology
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, James Duffin
Summary: This study compared the use of transfer function analysis (TFA) and conventional arterial input function (AIF) analysis in calculating cerebral perfusion metrics. The results showed that the metrics obtained through TFA were congruent with those obtained through conventional analysis, and TFA provided improved regional discrimination.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chu Hyun Kim, Ji Hyun Lee, Ji Won Lee, Eunju Kim, Sang-Hee Choi
Summary: This study aimed to evaluate the feasibility of using the BOLD technique to assess the response to NChT in osteosarcoma patients. The R2* values were found to have better correlation with the pathologic grade in the extraosseous portion. The BOLD MRI technique may be a useful biomarker for evaluating treatment response in osteosarcoma treated with NchT.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Alex A. Bhogal, Ece Su Sayin, Julien Poublanc, James Duffin, Joseph A. Fisher, Olivia Sobcyzk, David J. Mikulis
Summary: Cerebral blood arrival and tissue transit times are sensitive measures of tissue perfusion efficiency. Utilizing the SHOCS method, arterial blood arrival times throughout the brain were quantified with different onset times in gray and white matter. The average whole brain transit time was approximately 4.5 seconds. Additionally, SHOCS showed potential in assessing collateral blood flow in patients with vascular diseases.
Review
Biochemistry & Molecular Biology
Shangjun Chen, Lu An, Shiping Yang
Summary: This mini-review summarizes the recent progress on low-molecular-weight Fe(III) complexes, which are considered as promising alternatives to clinically used Gd(III)-based contrast agents in MRI. The relationships between the structure of the complexes and their relaxivity and thermodynamic stability are highlighted. Future perspectives for the design of low-molecular-weight Fe(III) complexes for MRI contrast agents are also suggested.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey M. Dendy, Sean G. Hughes, Jonathan H. Soslow, Daniel E. Clark, Cynthia B. Paschal, John C. Gore
Summary: We propose a method for quantitatively measuring drug-induced microvascular volume changes and blood oxygenation using calibrated blood oxygen level-dependent MRI. Through the examination of healthy rats, we demonstrate the potential of this method to examine microvascular disease in different disease states without the use of radiopharmaceuticals or gadolinium-based contrast agents.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Psychology, Developmental
Boris William Boettinger, Sarah Baumeister, Sabina Millenet, Gareth J. Barker, Arun L. W. Bokde, Christian Buechel, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Tobias Banaschewski, Daniel Brandeis, Frauke Nees
Summary: The study found that brain responses during negative affective face processing in healthy adolescents are influenced by the CP dimension. Specifically, there was a linear increase in left orbitofrontal cortex activity with increasing CP up to the clinical range in the full sample, while a significant inverted U-shaped effect was observed in individuals with high CP.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Clinical
Francesca Biondo, Charlotte Nymberg Thunell, Bing Xu, Congying Chu, Tianye Jia, Alex Ing, Erin Burke Quinlan, Nicole Tay, Tobias Banaschewski, Arun L. W. Bokde, Christian Buechel, Sylvane Desrivieres, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Herve Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Edward D. Barker, Gunter Schumann
Summary: This study revealed sex differences in the neural correlates of hyperactivity/inattention symptoms in adolescents, with boys showing lower grey matter volume in specific brain regions and girls showing higher grey matter volume in certain regions. These findings underscore the importance of considering sex when examining mechanisms underlying psychopathology in adolescence.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Laurent Elkrief, Bochao Lin, Mattia Marchi, Mohammad H. Afzali, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jurjen Luykx, Marco P. Boks, Patricia J. Conrod
Summary: This study examines the relationship between cannabis use, genetic risk for schizophrenia, and psychotic-like experiences. The results suggest that cannabis use remains a risk factor for psychotic-like experiences, above and beyond genetic vulnerability for schizophrenia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Lisa J. Pijnenburg, Anais Kaplun, Lieuwe de Haan, Magdalena Janecka, Lauren Smith, Abraham Reichenberg, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Eva Velthorst
Summary: This study suggests that autistic traits are associated with less frequent and lower quantity of alcohol use during adolescence. Adolescents with higher levels of autistic traits, including social impairment, detail orientation, and anxiety, were found to consume less alcohol and engage in less binge drinking.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Helene Vulser, Herve S. Lemaitre, Stella Guldner, Pauline Bezivin-Frere, Martin Loffler, Anna S. Sarvasmaa, Jessica Massicotte-Marquez, Eric Artiges, Marie-Laure Paillere Martinot, Irina Filippi, Ruben Miranda, Argyris Stringaris, Betteke Maria van Noort, Jani Penttila, Yvonne Grimmer, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Juliane H. Frohner, Hugh Garavan, Antoine Grigis, Penny A. Gowland, Andreas Heinz, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Philip A. Spechler, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Jean-Luc Martinot, Frauke Nees
Summary: Adolescence is a critical period for circadian rhythm, with a shift toward eveningness. Eveningness in adolescence predicts later onset of depressive symptoms. This study investigates the structural variations associated with chronotype in early adolescence and its contribution to the development of depressive symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Raka Maitra, Charlotte M. Horne, Owen O'Daly, Evangelos Papanastasiou, Christian Gaser, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne M. Winterer, Robert Whelan, Erin Burke Quinlan, Alex Ing, Gunter Schumann, Sukhi Shergill
Summary: The study found that Psychotic Like Experiences (PLEs) in adolescents are associated with changes in cortical gyrification, indicating abnormal neurodevelopment. Adolescents with higher PLEs had lower cortical gyrification in the fronto-temporal regions in the left hemisphere, and higher cortical gyrification in the right parietal cortex during late adolescence. The study also revealed that adolescents with high PLEs were 5.6 times more likely to develop psychosis by age 23.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Multidisciplinary Sciences
Jana Hutter, Vikram Kohli, Neele Dellschaft, Alena Uus, Lisa Story, Johannes K. Steinweg, Penny Gowland, Joseph Hajnal, Mary A. Rutherford
Summary: This study provides a qualitative and quantitative MRI assessment of pre-labour uterine contractions, aiming to contribute to the understanding of this important phenomenon and provide a tool for in-vivo study.
SCIENTIFIC REPORTS
(2022)
Article
Neuroimaging
Gita Thapaliya, Sally Eldeghaidy, Michael Asghar, Jordan McGing, Shellie Radford, Susan Francis, Gordon William Moran
Summary: This study investigates brain morphometry in patients with Crohn's disease and finds that there are alterations in brain structure, including reduced volume in certain regions, increased volume in others, and atrophy of the supplementary motor area. These structural changes are likely a result of chronic inflammation, abdominal pain, extraintestinal manifestations, and fatigue.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Computer Science, Interdisciplinary Applications
J. Thewlis, D. Stevens, H. Power, D. Giddings, P. Gowland, M. Vloeberghs
Summary: This study introduces a four-dimensional local radial basis function interpolation method for reconstructing complex flow phenomena in medical image velocimetry datasets. The proposed method shows promising results in both experiments and applications, offering a potential tool for medical diagnoses and drug delivery.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhipeng Cao, Renata B. Cupertino, Jonatan Ottino-Gonzalez, Alistair Murphy, Devarshi Pancholi, Anthony Juliano, Bader Chaarani, Matthew Albaugh, Dekang Yuan, Nathan Schwab, James Stafford, Anna E. Goudriaan, Kent Hutchison, Chiang-Shan R. Li, Maartje Luijten, Martine Groefsema, Reza Momenan, Lianne Schmaal, Rajita Sinha, Ruth J. van Holst, Dick J. Veltman, Reinout W. Wiers, Bernice Porjesz, Tristram Lett, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rudiger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Gunter Schumann, Robert Whelan, Ravi R. Bhatt, Alyssa Zhu, Patricia Conrod, Neda Jahanshad, Paul M. Thompson, Scott Mackey, Hugh Garavan
Summary: In this study, researchers identified a shared spatial pattern of cortical thickness (CT) in normative development and several psychiatric and neurological disorders. Further analysis revealed significant spatial correspondences between this pattern and widespread lower CT observed in psychiatric disorders, as well as the spatial pattern of normative maturation and aging. Transcriptional analysis also identified a set of genes closely related to this pattern, indicating disrupted neurodevelopment in the pathogenesis of psychiatric diseases emerging during adolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Alice Chavanne, Marie Laure Paillere Martinot, Jani Penttilae, Yvonne Grimmer, Patricia Conrod, Argyris Stringaris, Betteke van Noort, Corinna Isensee, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah S. Hohmann, Sabina Millenet, Juliane Froehner, Michael Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jean-Luc Martinot, Eric Artiges
Summary: Recent studies have found MRI correlates of prospective anxiety symptoms in youth, but their predictive value is still uncertain. This study used machine-learning algorithms to predict clinical anxiety using MRI data and psychometric scores. The results showed that psychometric features were the main predictors for overall anxiety disorders, while MRI regional volumes were more valuable for predicting GAD. In conclusion, future clinical anxiety in non-anxious 14-year-old adolescents can be individually predicted using psychometric features, and including neuroanatomical data improves the prediction of GAD.
MOLECULAR PSYCHIATRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Harshvardhan Gazula, Kelly Rootes-Murdy, Bharath Holla, Sunitha Basodi, Zuo Zhang, Eric Verner, Ross Kelly, Pratima Murthy, Amit Chakrabarti, Debasish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kumaran Kalyanaraman, Krishnaveni Ghattu, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivieres, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Mireille Toledano, Nilakshi Vaidya, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruhl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Juliane H. Frohner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Jessica A. Turner, Anand D. Sarwate, Sergey M. Plis, Vivek Benegal, Gunter Schumann, Vince D. Calhoun
Summary: With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks.
Article
Cardiac & Cardiovascular Systems
Bryan Haddock, Kasper B. B. Kristensen, Mahvish Tayyab, Henrik B. W. Larsson, Ulrich Lindberg, Mark Vestergaard, Susan Francis, Boye L. L. Jensen, Ulrik B. B. Andersen, Ali Asmar
Summary: GLP-1 receptor agonists have beneficial effects on cardiovascular and renal outcomes. GLP-1 can increase renal medullary and cortical perfusion in healthy humans, while maintaining renal oxygenation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Meshari T. Alshammari, Ali S. Alyami, Victoria Wilkinson-Smith, Robin C. Spiller, Penny Gowland, Luca Marciani, Gordon W. Moran, Caroline L. Hoad
Summary: This study evaluated the reliability and variability of MRI tagging techniques for assessing colonic chyme mixing. The results showed that this technique can accurately assess the mixing of food in the colon and has high inter-rater agreement. Furthermore, the reliability of the technique did not significantly vary over time.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Neurosciences
Radu Tanasescu, Olivier Mougin, I-Jun Chou, Ali Al-Radaideh, Oltita P. Jerca, Su-Yin Lim, Penny Gowland, Cris S. Constantinescu
Summary: Natalizumab can prevent the progression of microstructural tissue damage in patients with multiple sclerosis, as shown by high-field MRI.
