期刊
MAGNETIC RESONANCE IN MEDICINE
卷 59, 期 5, 页码 1111-1119出版社
WILEY
DOI: 10.1002/mrm.21575
关键词
injection shape; pharmacokinetic model; system identification; DCE-MRI; arterial input function; AIF; tracer distribution model; TDM; tumor perfusion
Optimization of experimental settings of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), like the contrast administration protocol, is of great importance for reliable quantification of the microcirculatory properties, such as the volume transfer-constant K-trans. Using system identification theory and computer simulations, the confounding effects of volume, rate and multiplicity of a contrast injection on the reliability of Ktrans estimation was assessed. A new tracer-distribution model (TDM), based on in vivo data from rectal cancer patients, served to describe the relationship between the contrast agent injection and the blood time-course. A pharmaco-kinetic model (PKM) was used to describe the relation between the blood and tumor tissue time-courses. By means of TDM and PKM in series, the tissue-transfer function of the PKM was analyzed. As both the TDM and PKM represented low-frequency-pass filters, the energy-density at low frequencies of the blood and tissue time-courses was larger than at high frequencies. The simulations, based on measurements in humans, predict that the Ktrans is most reliable with a high injection volume administered in a single injection, where high rates only modestly improve Ktrans.
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