期刊
MAGNETIC RESONANCE IN MEDICINE
卷 60, 期 1, 页码 213-219出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21596
关键词
relaxation; measurement; spinal cord; 3 Tesla T1; T2
资金
- NCRR NIH HHS [RR 015241, P41 RR015241, P41 RR015241-08] Funding Source: Medline
- NIBIB NIH HHS [P41 EB015909, R21 EB000991, EB 000991] Funding Source: Medline
T-1 and T-2 were measured for white matter (WM) and gray matter (GM) in the human cervical spinal cord at 3T. T-1 values were calculated using an inversion-recovery (IR) and Bi-corrected double flip angle gradient echo (GRE) and show significant differences (p = 0.002) between WM (IR = 876 +/- 27 ms, GRE = 838 +/- 54 ms) and GM (IR = 973 +/- 33 ms, GRE 994 +/- 54 ms). IR showed significant difference between lateral and dorsal column WM (863 +/- 23 ms and 899 +/- 18 ms, respectively, p = 0.01) but GRE did not (p = 0.40). There was no significant difference (p = 0.31) in T-2 between WM (73 +/- 6 ms) and GM (76 +/- 3 ms) or between lateral and dorsal columns (lateral: 73 +/- 6 ms, dorsal: 72 +/- 7 ms, p = 0.59). WM relaxation times were similar to brain structures with very dense fiber packing (e.g., corpus callosum), while GM values resembled deep GM in brain. Optimized sequence parameters for maximal contrast between WM and GM, and between WM and cerebrospinal fluid (CSF) were derived. Since the spinal cord has rostral-caudal symmetry, we expect these findings to be applicable to the wholecord.
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