Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaodong Zhong, Houchun H. Hu, Tess Armstrong, Xinzhou Li, Yu-Hsiu Lee, Tsu-Chin Tsao, Marcel D. Nickel, Stephan A. R. Kannengiesser, Brian M. Dale, Vibhas Deshpande, Berthold Kiefer, Holden H. Wu
Summary: The stack-of-radial MRI with self-gating motion compensation has shown potential for free-breathing liver R2* and PDFF quantification in children. The study results demonstrated good consistency between two observers in subject inclusion decisions and high agreement in measurements and phantom results. Interobserver agreement was excellent for both PDFF and R2* measurements.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Engineering, Biomedical
Martijn M. A. Dietze, Britt Kunnen, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
Summary: The study aimed to evaluate the performance of a respiratory motion compensation technique in phantom experiments for fluoroscopy-guided interventional procedures. The results demonstrated that motion compensation improved the visual quality of nuclear projections and SPECT reconstructions, leading to a significant reduction in mean error in activity recovery.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Shenghui Yang, Shiqiang Li, Xiaoxue Jia, Yonghua Cai, Yifei Liu
Summary: This paper proposes a translational motion compensation method for rapidly spinning targets by analyzing the correlation between echoes, achieving high-precision envelope alignment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Henrik von Kleist, Martin Buehrer, Sebastian Kozerke, Kwannapas Saengsin, Jamie K. Harrington, Andrew J. Powell, Mehdi H. Moghari
Summary: The newly developed self-gating algorithm using blind source separation for 2D cine SSFP imaging showed comparable results to the standard ECG-gating method in terms of cardiac cycle length, image quality metrics, and ventricular volume measurements. This technique may simplify patient preparation, be more robust in cases of arrhythmia, and enable cardiac gating at higher field strengths.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin G. Wagner, Sarvesh Periyasamy, Colin Longhurst, Matthew J. McLachlan, Joseph F. Whitehead, Michael A. Speidel, Paul F. Laeseke
Summary: The study aimed to develop a dynamic respiratory motion compensated device guidance system and evaluate its accuracy and real-time performance in an in vivo porcine liver model. The results showed that the system increased the accuracy of the displayed device position relative to the hepatic vasculature.
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Hendrik Pretorius, Michael A. King
Summary: The study aimed to recover a surrogate respiratory signal from SPECT projection data using a data-driven approach and evaluated the clinical efficacy of this method. Results showed potential for automated correction of cardiac respiratory motion with the COM method, although it may not be equivalent to the traditional VTS methodology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Mayer, Thomas-Heinrich Wurster, Tobias Schaeffter, Ulf Landmesser, Andreas Morguet, Boris Bigalke, Bernd Hamm, Winfried Brenner, Marcus R. Makowski, Christoph Kolbitsch
Summary: The study aimed to apply an MR-based motion compensation framework to [F-18]NaF data for high-resolution motion-compensated PET and MR images. The results showed that MR-based motion models successfully improved target-to-background ratios, contrast-to-background ratios, and plaque diameter in the coronary system. Dynamic attenuation correction effectively reduced attenuation correction artifacts and enabled more reliable plaque localization.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juliane Ludwig, Peter Speier, Frank Seifert, Tobias Schaeffter, Christoph Kolbitsch
Summary: Prospective motion correction using the pilot tone as a respiratory motion signal improved image quality and scan efficiency for cardiac cine imaging, with significant improvement in contrast-to-noise ratio and sharpness of endocardium.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ronald Mooiweer, Radhouene Neji, Sarah McElroy, Muhummad Sohaib Nazir, Reza Razavi, Amedeo Chiribiri, Sebastien Roujol
Summary: A fast respiratory navigator called fastNAV was developed for cardiac MR perfusion imaging, showing improved image quality and reduced heart displacement in real-time respiratory tracking.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chong Chen, Preethi Chandrasekaran, Yingmin Liu, Orlando P. Simonetti, Matthew Tong, Rizwan Ahmad
Summary: A new automatic method for selecting heartbeats with consistent respiratory phase in real-time cardiac MRI has been developed, improving the accuracy of cardiac function quantification. Results show high positive correlation between the extracted respiratory signal using this method and the reference, particularly enhancing right ventricular function quantification.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tinsu Pan, M. Allan Thomas, Dershan Luo
Summary: A new automated DDG CT method was developed to address misregistration and tumor motion issues in PET/CT imaging. DDG CT showed greater consistency in selecting end-expiratory phase images compared to the clinical standard of 4D CT. It appeared to be more robust in regions prone to misregistration and tumor motion, and provided improved attenuation correction for DDG PET relative to D4D CT. DDG CT offered the benefits of 4D CT without the need for external device gating, making it a promising tool in PET/CT imaging.
Article
Biochemical Research Methods
Ruizhi Zuo, Kristina Irsch, Jin U. Kang
Summary: This study proposes an OCT system for real-time 3D motion compensation of corneal tissue using higher-order regression. By comparing reference and volumetric images, a surface detection algorithm and higher-order polynomials are used to remove motion artifacts.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joscha Maier, Sergej Lebedev, Julien Erath, Elias Eulig, Stefan Sawall, Eric Fournie, Karl Stierstorfer, Michael Lell, Marc Kachelriess
Summary: Deep PAMoCo is a method for estimating and compensating coronary artery motion, which uses a deep neural network to enhance computational performance and quality of motion-compensated reconstructions. The results demonstrate that Deep PAMoCo can effectively remove motion artifacts and improve the diagnostic value of cardiac CT scans, outperforming other approaches in terms of processing time and accuracy.
Article
Engineering, Biomedical
M. P. Reymann, A. H. Vija, A. Maier
Summary: This study aims to analyze the application of data driven gating (DDG) algorithms in single photon emission computed tomography (SPECT). By performing Monte Carlo simulation of phantoms, we evaluated the accuracy of two DDG algorithms and found that view angle, object size, count rate density, and contrast have significant impact on the algorithms.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Physics, Multidisciplinary
Patrick Metze, Hanna Frantz, Fabian Straubmueller, Tobias Speidel, Kilian Stumpf, Meinrad Beer, Wolfgang Rottbauer, Volker Rasche
Summary: The purpose of this study was to adapt the non-uniform self-gating (nuSG) method and compare it to established self-gating approaches for lung imaging. The results showed that nuSG is capable of reconstructing high-quality images for both uniform and non-uniform breathing patterns, and can resolve additional motion or lack of clear motion surrogate.
FRONTIERS IN PHYSICS
(2022)
Article
Cardiac & Cardiovascular Systems
Muhummad Sohaib Nazir, Joy Shome, Adriana D. M. Villa, Matthew Ryan, Ziyan Kassam, Reza Razavi, Sebastian Kozerke, Tevfik F. Ismail, Divaka Perera, Amedeo Chiribiri, Sven Plein
Summary: 2D high resolution and 3D whole heart myocardial perfusion stress CMR are comparable for detection of ischaemia. 2D high resolution gives higher values for myocardial ischaemic burden compared with 3D whole heart, suggesting that 2D high resolution is more sensitive for detection of ischaemia.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Malgorzata Polacin, Mihaly Karolyi, Christian Bluthgen, Nik Pilz, Matthias Eberhard, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Summary: This study found that late gadolinium enhancement with fixed short inversion time (LGE(short)) provides better visibility of ischemic scars compared to clinically established LGE (LGE(standard)) and shows equivalent visibility of non-ischemic LGE. Less experienced readers can diagnose ischemic and non-ischemic LGE faster in LGE(short).
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robbert J. H. van Gorkum, Christian Guenthner, Andreas Koethe, Christian T. Stoeck, Sebastian Kozerke
Summary: The study aims to characterize system nonlinearity induced by diffusion gradients and propose a correction method for improving image quality in motion-compensated cardiac DTI using echo-planar and spiral trajectories.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobias Hoh, Valery Vishnevskiy, Malgorzata Polacin, Robert Manka, Maximilian Fuetterer, Sebastian Kozerke
Summary: This study proposes the respiratory motion-informed locally low-rank reconstruction (MI-LLR) for robust free-breathing 3D myocardial perfusion CMR imaging. The results show that MI-LLR achieves improved uniformity and stability compared to other reconstruction methods under rest and stress conditions.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sophie M. Peereboom, Sebastian Kozerke
Summary: This study proposes a method that combines echo-planar spectroscopic imaging (EPSI) with motion-adapted gating, weighted acquisition, and metabolite cycling to detect triglyceride-to-water ratios in different regions of the human heart. The scan time is reduced to less than 10 minutes while maintaining the quality of triglyceride fitting constant. The method is compared to single-voxel measurements and conventional acquisition methods.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Thomas Joyce, Stefano Buoso, Christian T. Stoeck, Sebastian Kozerke
Summary: In this paper, a differentiable volumetric mesh voxelization technique based on deformation of a shape model is proposed. It can directly predict left-ventricular anatomies from magnetic resonance image slice data, producing volumetric meshes suitable for biophysical simulations. The method does not require paired training data and is able to accurately predict and combine information from images acquired in different views, while also being faster and more robust than a state-of-the-art registration based method.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Arka Das, Christopher Kelly, Irvin Teh, Christian T. Stoeck, Sebastian Kozerke, Noor Sharrack, Peter P. Swoboda, John P. Greenwood, Jurgen E. Schneider, Sven Plein, Erica Dall'Armellina
Summary: This study used diffusion tensor cardiac magnetic resonance (DT-CMR) to evaluate the left ventricular remodeling in patients with ST-segment elevation myocardial infarction (STEMI), and found potential associations between DT-CMR parameters and adverse remodeling.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Computer Science, Artificial Intelligence
Ezgi Berberoglu, Christian T. Stoeck, Sebastian Kozerke, Martin Genet
Summary: Cardiovascular magnetic resonance (CMR) imaging is the gold standard for assessing left-ventricular (LV) function non-invasively. Previous studies have shown the prognostic value of deformation metrics extracted from regular SSFP CMR images, although they have limitations in detecting myocardial torsion. Tagged CMR allows for the assessment of local myocardial deformation, including torsion, but is limited in quantifying radial strain. To overcome these limitations, a fusion of global shape motion from SSFP images and local deformation from tagged images is proposed. Joint analysis of SSFP and 3DTAG images provides better quantification of LV strain and twist compared to using either data source alone.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Pietro Dirix, Stefano Buoso, Eva S. Peper, Sebastian Kozerke
Summary: This study proposes a method to synthesize patient-specific 4D flow MRI datasets of turbulent flow paired with ground truth flow data for training of inference methods. The results demonstrate the importance of paired ground truth and 4D flow MRI data for accurately assessing turbulent flow inference using 4D flow MRI exams.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Traechtler, Maximilian Fuetterer, Mohammed M. Albannay, Tobias Hoh, Sebastian Kozerke
Summary: In hyperpolarized MR, signal-to-noise ratio (SNR) is not linearly dependent on field strength. Lower fields alleviate field inhomogeneity-induced artifacts and practical limitations associated with stronger fields. The potential of hyperpolarized 13C spectroscopy and imaging at 1.5T versus 3T is demonstrated for clinical applications.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Sophie M. Peereboom, Christian Guenthner, Mohammed M. Albannay, Sebastian Kozerke
Summary: This study aimed to investigate the scaling of signal-to-noise ratio (SNR) of point-resolved spectroscopy with field strength and to test the feasibility of proton MRS of triglycerides (TGs) in human myocardium at 0.75 T. The results showed that proton MRS of TGs in myocardium is feasible at 0.75 T.
NMR IN BIOMEDICINE
(2023)
Article
Physiology
Johanna Stimm, David A. Nordsletten, Javiera Jilberto, Renee Miller, Ezgi Berberoglu, Sebastian Kozerke, Christian T. Stoeck
Summary: Simulations of cardiac electrophysiology and mechanics are sensitive to the microstructural anisotropy of the myocardium. Personalized cardiac models based on in-vivo cDTI data can reduce bias in simulation results.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mihaly Karolyi, Alexander Gotschy, Malgorzata Polacin, Sven Plein, Ingo Paetsch, Cosima Jahnke, Michael Frick, Rolf Gebker, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Summary: This study aimed to test the accuracy of 3D cardiac magnetic resonance stress perfusion in the elderly population compared to reference standard fractional flow reserve (FFR). The results showed that 3D CMR perfusion has excellent diagnostic accuracy for the detection of hemodynamically relevant coronary stenosis, independent of patient age.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander Gotschy, Suzana Jordan, Christian T. Stoeck, Constantin von Deuster, Tatiana Peer, Mareike Gastl, Valery Vishnevskiy, Lukas Wissmann, Rucsandra Dobrota, Carina Mihai, Mike O. Becker, Britta Maurer, Sebastian Kozerke, Frank Ruschitzka, Oliver Distler, Robert Manka
Summary: In this study, cardiovascular magnetic resonance (CMR) was used to investigate the temporal onset of myocardial involvement and its prognostic value in patients with systemic sclerosis (SSc). The results showed that subclinical functional impairment first manifests as diffuse myocardial fibrosis in patients with very early diagnosis of SSc (VEDOSS), while established SSc patients exhibit subtle ventricular dysfunction. Elevated native T1 and reduced GLS were associated with increased risk of death, with native T1 being predictive for cardiovascular mortality.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Malgorzata Polacin, Mihaly Karolyi, Verena Wilzeck, Matthias Eberhard, Alexander Gotschy, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Summary: This study aims to compare the differences in measuring bilayered myocardium in LVNC using three-dimensional whole-heart MRI and standard two-dimensional cine MRI. The results showed that three-dimensional whole-heart MRI has higher image quality, better structure discrimination, and better interobserver agreement compared to standard two-dimensional cine MRI.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2022)