期刊
MAGNETIC RESONANCE IN CHEMISTRY
卷 51, 期 6, 页码 358-363出版社
WILEY
DOI: 10.1002/mrc.3958
关键词
focused library; natural product scaffold; polyandrocarpamine; microwave chemistry; physicochemical parameters; 2-aminoimidazolone
资金
- Griffith University
- Eskitis Institute
A focused library based on the marine natural products polyandrocarpamines A (1) and B (2) has been designed and synthesised using parallel solution-phase chemistry. In silico physicochemical property calculations were performed on synthetic candidates in order to optimise the library for drug discovery and chemical biology. A library of ten 2-aminoimidazolone products (3-12) was prepared by coupling glycocyamidine and a variety of aldehydes using a one-step stereoselective aldol condensation reaction under microwave conditions. All analogues were characterised by NMR, UV, IR and MS. The library was evaluated for cytotoxicity towards the prostate cancer cell lines, LNCaP, PC-3 and 22Rv1. Copyright (C) 2013 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据