Article
Biochemistry & Molecular Biology
Kara M. Edwards, Aishwarya Badiger, Dennis R. Heldman, Matthias S. Klein
Summary: This study investigates the impact of storage temperature and time on the concentration of key metabolites in milk, providing insights into the factors affecting milk stability. Different metabolites exhibit varying responses to storage time and temperature, with potential implications for real-time shelf-life monitoring and reduction of milk waste.
Article
Environmental Sciences
Mark Annunziato, Muhamed N. H. Eeza, Narmin Bashirova, Ariel Lawson, Joerg Matysik, Daniel Benetti, Martin Grosell, John D. Stieglitz, A. Alia, John P. Berry
Summary: Brevetoxins are neurotoxins associated with harmful algal blooms, with research on toxicity mechanisms and biomarkers aiding in understanding environmental impacts. Metabolic profiling using HRMAS NMR on zebrafish embryos exposed to PbTx-2 revealed acute embryotoxicity in both zebrafish and mahi-mahi at environmentally relevant concentrations. Metabolomics studies provided insight into potential biomarkers and toxicity pathways at environmentally relevant toxin levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Polymer Science
Luis M. Araque, Claudio J. Perez, Antonia Infantes-Molina, Enrique Rodriguez-Castellon, Guillermo J. Copello, Juan M. Lazaro-Martinez
Summary: Two responsive PEI hydrogels (P1.5E and P2E) with different cross-linking degrees were synthesized using a click reaction and without organic solvents. The hydrogel's swelling and rheological behavior were dependent on the cross-linking degree, and the hydrogels showed stimuli-responsive behavior to pH or ionic strength changes. The hydrogels also exhibited adsorption capacity for methyl orange (MO) dye and Cu2+ ions, with P1.5E showing higher sorption capacities. Germination experiments with lettuce seeds confirmed that the hydrogels did not release toxic molecules.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Oncology
Mohammad Alwahsh, Robert Knitsch, Rosemarie Marchan, Joerg Lambert, Christian Hoerner, Xiaonan Zhang, Berthold Schalke, De-Hyung Lee, Elena Bulut, Thomas Graeter, German Ott, Katrin S. Kurz, Gerhard Preissler, Sebastian Schoelch, Joviana Farhat, Zhihan Yao, Carsten Sticht, Philipp Stroebel, Roland Hergenroeder, Alexander Marx, Djeda Belharazem
Summary: This study is the first metabolomics investigation on thymic epithelial tumors, which identified differential metabolic profiles among different subtypes and predicted activated metabolic pathways. These findings provide new insights for the treatment of aggressive thymomas and thymic carcinomas.
Article
Microbiology
Gaia Meoni, Veronica Ghini, Laura Maggi, Alessia Vignoli, Alessio Mazzoni, Lorenzo Salvati, Manuela Capone, Anna Vanni, Leonardo Tenori, Paolo Fontanari, Federico Lavorini, Adriano Peris, Alessandro Bartoloni, Francesco Liotta, Lorenzo Cosmi, Claudio Luchinat, Francesco Annunziato, Paola Turano
Summary: The research analyzed the metabolites of COVID-19 patients and controls using NMR, finding common plasma metabolomic and lipidomic signatures in COVID-19 patients. Tocilizumab treatment was shown to partially reverse the metabolic alterations caused by SARS-CoV-2 infection.
Article
Chemistry, Multidisciplinary
Francesca Nardelli, Emilia Bramanti, Alessandro Lavacchi, Silvia Pizzanelli, Beatrice Campanella, Claudia Forte, Enrico Berretti, Angelo Freni
Summary: This study investigated the thermal stability and corrosion effects of a promising ionic liquid (IL) to be used as an advanced heat transfer fluid in solar thermal energy applications. Degradation tests were conducted on IL samples in contact with different metals, and various analytical techniques were employed to verify the occurrence of degradation processes due to aging.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Kathryn E. Anderssen, Evan R. McCarney
Summary: This article discusses the applications of nuclear magnetic resonance in studying meat and seafood products, highlighting the challenges in interpreting transverse relaxation in muscle tissue. The research delves into the relaxation mechanisms in muscle tissue, identifying the source of different T-2 peaks in the spectrum and how they relate to changes in tissue microstructure.
Article
Biochemistry & Molecular Biology
Nicola Cavallini, Francesco Savorani, Rasmus Bro, Marina Cocchi
Summary: With the increasing interest of consumers in beer consumption, the field of beeromics is continuously growing, requiring quick and exhaustive analytical methods. This study proposed a combination of nuclear magnetic resonance spectroscopy and chemometrics to characterize beer, demonstrating that the resolved information is comparable with the full spectrum information but with improved interpretability.
Article
Biochemistry & Molecular Biology
Serafina Perrone, Simona Negro, Elisa Laschi, Marco Calderisi, Maurizio Giordano, Giuseppe De Bernardo, Gianni Parigi, Anna Laura Toni, Susanna Esposito, Giuseppe Buonocore
Summary: Metabolomics can assess and compare the metabolomic profiles of individuals born preterm and at term, showing that the urinary spectra of preterm young adults are different from those born at term and resemble the profiles at birth. The Random Forest algorithm with an accuracy of 82% identified specific metabolites responsible for the classification, indicating the potential of using urine spectra for early identification of neonates at risk of adult diseases.
Article
Food Science & Technology
Federica Barbieri, Luca Laghi, Chiara Montanari, Qiuyu Lan, Alessia Levante, Fausto Gardini, Giulia Tabanelli
Summary: In this study, a metabolomic approach was used to compare five different strains of Latilactobacillus sakei. The results showed that the metabolic diversity of L. sakei is related to its functionality in fermented sausages, and nuclear magnetic resonance (H-1-NMR) is an effective method for the rapid identification of different classes of compounds.
Article
Environmental Sciences
Chiara Roberta Girelli, Francesca Serio, Rita Accogli, Federica Angile, Antonella De Donno, Francesco Paolo Fanizzi
Summary: The H-1-NMR based characterization of Salento chicory varieties allowed us to determine the potential usefulness and nutraceutical properties of the product, also providing a method to guarantee its authenticity on a molecular scale. Results showed differences in free amino acids and organic acids content among the varieties, with Leccese variety exhibiting high levels of cichoric and monocaffeoyl tartaric acid. The presence of secondary metabolites in Cichorium intybus adds significant interest in its investigation for potential health benefits.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Dietrich Knorr, Mary Ann Augustin
Summary: This paper highlights uncertainties and conscious ignorance in food science, driving scientists to ask better research questions. Various illustrations are provided to demonstrate gaps in knowledge and uncertainties, with opportunities for future research suggested. The importance of gaining deeper insights into food systems through long-term research is emphasized.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuya Zhang, Xu Qiu, Yue Zhang, Caihua Huang, Donghai Lin
Summary: Trehalose treatment and pretreatment were found to modulate oxidant metabolism and amino acid metabolism, as revealed by NMR-based metabolomics analysis. Additionally, trehalose upregulated the expression of P62 and Nrf2 proteins, activating the Nrf2-NQO1 axis and effectively reducing oxidative stress. These findings suggest that trehalose supplementation could be a promising strategy for alleviating oxidative stress in skeletal muscle and have potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Penuelas, Jesus Ruiz-Cabello, Jose L. Izquierdo-Garcia
Summary: This study compared the metabolic alterations induced by COVID-19 and Influenza A pneumonia (IAP) in ARDS patients, finding that these two conditions lead to different regulation of metabolic pathways. COVID-19 patients experience a significant energy supply deficit, while IAP patients exhibit more marked inflammatory and oxidative stress responses. The findings suggest a potential biomarker for diagnosing, prognosticating, and managing ARDS patients with different etiologies.
Article
Dentistry, Oral Surgery & Medicine
Oscar Musalem-Dominguez, Jose Maria Montiel-Company, Veronica Ausina-Marquez, Jose Manuel Morales-Tatay, Jose Manuel Almerich-Silla
Summary: This study identified metabolomic differences in saliva between healthy children and children with active carious lesions, and developed a predictive model based on the salivary metabolomic profile. The results showed differences in metabolites, particularly saccharides and amino acids, between the two groups, suggesting their association with caries risk. These findings contribute to the research of salivary biomarkers, caries risk assessment, and personalized prevention strategies.
JOURNAL OF DENTISTRY
(2023)
Article
Food Science & Technology
Vito Gallo, Rosa Ragone, Biagia Musio, Stefano Todisco, Antonino Rizzuti, Piero Mastrorilli, Stefania Pontrelli, Nicola Intini, Pasquale Scapicchio, Maurizio Triggiani, Antonello Pascazio, Carlos Cobas, Silvia Mari, Cristiano Garino, Marco Arlorio, Domenico Acquotti, Cristina Airoldi, Fabio Arnesano, Michael Assfalg, Andersson Barison, Francesca Benevelli, Anna Borioni, Laura Ruth Cagliani, Luca Casadei, Flaminia Cesare Marincola, Kim Colson, Roberto Consonni, Gabriele Costantino, Mauro Andrea Cremonini, Silvia Davalli, Iola Duarte, Sophie Guyader, Erwann Hamon, Maren Hegmanns, Raffaele Lamanna, Francesco Longobardi, Domenico Mallamace, Stefano Mammi, Michelle Markus, Leociley Rocha Alencar Menezes, Salvatore Milone, Dolores Molero-Vilchez, Adele Mucci, Claudia Napoli, Maria Cecilia Rossi, Elena Saez-Barajas, Francesco Savorani, Elisabetta Schievano, Fabio Sciubba, Anatoly Sobolev, Panteleimon G. Takis, Freddy Thomas, Palmira Villa-Valverde, Mario Latronico
FOOD ANALYTICAL METHODS
(2020)
Article
Multidisciplinary Sciences
Raquel Gonzalez-Blazquez, Martin Alcala, Maria S. Fernandez-Alfonso, Palmira Villa-Valverde, Marta Viana, Marta Gil-Ortega, Beatriz Somoza
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Ana Rey, Jose Francisco Segura, David Castejon, Encarnacion Fernandez-Valle, Ma Isabel Cambero, Luis Calvo
Article
Agriculture, Dairy & Animal Science
Maria Jose Ruiz-Fernandez, Sara Jimenez, Encarnacion Fernandez-Valle, M. Isabel Garcia-Real, David Castejon, Nerea Moreno, Maria Ardiaca, Andres Montesinos, Salvador Ariza, Juncal Gonzalez-Soriano
Article
Nanoscience & Nanotechnology
Juan Manuel Arango, Daniel Padro, Jorge Blanco, Sonia Lopez-Fernandez, Pilar Castellnou, Palmira Villa-Valverde, Jesus Ruiz-Cabello, Abraham Martin, Monica Carril
Summary: A novel fluorine labeling strategy was proposed in this study, which successfully synthesized potential fluorinated nanoparticles through conjugation of small fluorinated building blocks with gold nanoparticles. These nanoparticles exhibited potential applications in biological imaging in vivo using F-19 magnetic resonance spectroscopy in mice.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pediatrics
Aaron Del Pozo, Maria Villa, Carlos Vargas, David Castejon, M. Encarnacion Fernandez-Valle, Ana Gutierrez-Rodriguez, Jose Martinez-Orgado
Summary: This study successfully replicated the features of brain damage in extremely low birth weight newborns using a new rat model. Inflammation associated with blood-brain barrier dysfunction was identified as a potential therapeutic target for preventing brain damage.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Diego Rodriguez-Munoz, Angela Sanchez, Susana Perez-Benavente, Constanza Contreras-Jurado, Ana Montero-Pedrazuela, Marta Toledo-Castillo, Maria Gutierrez-Hernandez, Raquel Rodrigues-Diez, Cintia Folgueira, Ana M. Briones, Guadalupe Sabio, Ignacio Monedero-Cobeta, Irene Chavez-Coira, David Castejon, Encarnacion Fernandez-Valle, Javier Regadera, Jose M. Bautista, Ana Aranda, Susana Alemany
Summary: Thyroid hormones play a role in protecting mice from cerebral malaria by inducing disease tolerance. The activation of Sirtuin 1 is involved in this protection, suggesting it as a potential target for cerebral malaria treatment.
Article
Chemistry, Multidisciplinary
Ignacio Rodriguez, Jose Luis Izquierdo-Garcia, Ehsan Yazdanparast, David Castejon, Jesus Ruiz-Cabello
Summary: Magnetic resonance imaging (MRI) is a valuable diagnostic tool for providing detailed information about the human body. Accurate computation of relaxation time mapping is critical for clinical diagnosis and treatment planning. This article compares the performance of different algorithms, showing that the RD-NLS algorithm outperforms others in computing relaxation times in MRI, particularly for T1 maps.
APPLIED SCIENCES-BASEL
(2023)
Article
Agriculture, Dairy & Animal Science
Claudio Alba, David Castejon, Victor Remiro, Juan M. Rodriguez, Odon J. Sobrino, Julian de Maria, Pilar Fumanal, Antonio Fumanal, M. Isabel Cambero
Summary: Antibiotic usage in swine husbandry contributes to the emergence and dissemination of antibiotic-resistant bacteria, posing a serious threat to public health. In this study, the substitution of metaphylactic antimicrobials with the administration of the probiotic strain Ligilactobacillus salivarius MP100 showed beneficial productivity and quality outcomes. The probiotic intake did not negatively affect the meat composition and was associated with an increase in inosine concentration and a slight tendency for increasing the intramuscular fat content, which are considered as biomarkers of meat quality.
Article
Agriculture, Dairy & Animal Science
Lidia Blazquez-Llorca, Lubna Morales de Paz, Rosario Martin-Orti, Inmaculada Santos-Alvarez, Maria E. Fernandez-Valle, David Castejon, Maria I. Garcia-Real, Raquel Salguero-Fernandez, Pilar Perez-Lloret, Nerea Moreno, Sara Jimenez, Maria J. Herrero-Fernandez, Juncal Gonzalez-Soriano
Summary: Anatomy is crucial in medical and veterinary education, but neuroanatomy poses particular challenges. A new teaching tool has been developed using 3D reconstructions of magnetic resonance images to aid in the understanding of clinical neurology and practice. This tool combines neuroanatomy and neuropathology, providing valuable insights for anatomists and clinicians.
Meeting Abstract
Endocrinology & Metabolism
C. Granados Martinez, L. Alzamora, N. Alfageme, M. Fernandez-Valle, D. Castejon, D. Sevillano, G. Di, P. Calleja-Castano, J. Garcia-Segura, M. Moro, I. Lizasoain, J. Pradillo
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Critical Care Medicine
Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Penuelas, Jesus Ruiz-Cabello, Jose L. Izquierdo-Garcia
Summary: This study compared the metabolic alterations induced by COVID-19 and Influenza A pneumonia (IAP) in ARDS patients, finding that these two conditions lead to different regulation of metabolic pathways. COVID-19 patients experience a significant energy supply deficit, while IAP patients exhibit more marked inflammatory and oxidative stress responses. The findings suggest a potential biomarker for diagnosing, prognosticating, and managing ARDS patients with different etiologies.
Article
Chemistry, Physical
Julia Villalva, Sara Moreno-Da Silva, Palmira Villa, Luisa Ruiz-Gonzalez, Cristina Navio, Saul Garcia-Orrit, Victor Vega-Mayoral, Juan Cabanillas-Gonzalez, Andres Castellanos-Gomez, Emerson Giovanelli, Emilio M. Perez
Summary: The construction of van der Waals heterostructures and the decoration of 2D materials with organic molecules aim to obtain ultrathin materials with tailored properties. Utilizing controlled chemistry on van der Waals heterostructures can lead to complex mixed-dimensional heterostructures. Experimental results demonstrate that thiol-ene-like click chemistry can be applied to decorate franckeite, confirming the chemical mechanism and product structure through various analyses.
NANOSCALE HORIZONS
(2021)
Article
Chemistry, Multidisciplinary
Hugo Groult, Susana Carregal-Romero, David Castejon, Mikel Azkargorta, Ana-Beatriz Miguel-Coello, Krishna Reddy Pulagam, Vanessa Gomez-Vallejo, Remi Cousin, Maria Munoz-Caffarel, Charles H. Lawrie, Jordi Llop, Jean-Marie Piot, Felix Elortza, Thierry Maugard, Jesus Ruiz-Cabello, Ingrid Fruitier-Arnaudin
Summary: This study successfully prepared HEP-ESIONP probes with excellent MRI contrast using a one-pot microwave method with heparin oligosaccharides (HO) of different lengths as coatings, demonstrating anticoagulant properties and/or specific antitumor activity based on the length of HO used. In vivo distribution study showed significant changes in probe behaviors and renal clearance with shortening of HO length, while in vitro characterization of protein coronas provided insight into the crucial impact of HO length on opsonization-mediated immune response and elimination. The precise HO length identified in this study resulted in ESIONP probes with prolonged vascular lifetime, moderate tumor accumulation, low uptake by non-specific organs, and favorable urinary clearance, meeting prerequisites for advanced theranostic medical applications with dual MRI/PET hot spot capability and potential antitumor activity.
Article
Food Science & Technology
A. B. Garcia-Garcia, M. I. Cambero, D. Castejon, R. Escudero, M. E. Fernandez-Valle
FOOD STRUCTURE-NETHERLANDS
(2019)