期刊
MAGNETIC RESONANCE IMAGING
卷 31, 期 7, 页码 1068-1073出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2013.04.015
关键词
Iron deposition; Parkinson's disease; Enhanced 12 star weighted angiography; Magnetic resonance imaging; Phase value
资金
- National Science Foundation of China [81171327]
Conventional magnetic resonance imaging (MRI) assesses neurodegenerative structural changes in the cerebral anatomy of Parkinson's disease (PD) patients but cannot detect non-structural abnormalities; however, enhanced T2 star weighted angiography (ESWAN) can precisely indicate PD-related substantia nigra (SN) iron deposition. The differences in ESWAN-based parameters between different PD stages were assessed using midbrain iron deposits of 20 PD patients aged 64.3 +/- 12.7 (41-85) years grouped by Hoehn and Yahr staging into minimal (stages <= 2.5) or moderate to severe (stages >= 3.0) motor impairment groups and 14 healthy control subjects. Conventional MRI and ESWAN measurements of mean phase value (MPV) and midbrain dimensions (width and diameter) revealed similar anatomical characteristics; however, ESWAN revealed the presence of smaller MPVs and SN pars compacta (SNc) (P < 0.01) and a negative correlation between reduction extent and motor impairment (P < 0.01). SNc width to midbrain diameter was reduced in moderate to severe impairment patients versus control and minimal impairment patients (both P < 0.01). A positive correlation was found between MPV and width or SNc width to midbrain diameter ratio (P < 0.01 and P < 0.05, respectively). Minimal impairment group mean MPV and substantia nigra pars reticulata (SNr) width evidenced no significant reduction, unlike significant reductions in the moderate to severe impairment group (P < 0.01). No significant changes were observed in MPV or width in the RN region (P > 0.05). ESWAN allows for early and accurate iron deposition determination in PD patients, particularly useful as a supplement to conventional MRI in early-stage PD patients. Crown Copyright (c) 2013 Published by Elsevier Inc. All rights reserved.
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