期刊
MAGNETIC RESONANCE IMAGING
卷 31, 期 5, 页码 783-788出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2012.11.005
关键词
MRI; fMRI; Medical device safety; DES; Deep brain stimulation; 3.0 T
资金
- National Institute of Health [K08 NS 52232, R01 NS 70872]
Purpose: To present preliminary, in vivo temperature measurements during MRI of a pig implanted with a deep brain stimulation (DBS) system. Materials and Methods: DBS system (Medtronic Inc., Minneapolis, MN) was implanted in the brain of an anesthetized pig. 3.0-T MRI was performed with a T/R head coil using the low-SAR GRE EPI and IR-prepped GRE sequences (SAR: 0.42 and 0.39 W/kg, respectively), and the high-SAR 4-echo RF spin echo (SAR: 2.9 W/kg). Fluoroptic thermometry was used to directly measure RF-related heating at the DBS electrodes, and at the implantable pulse generator (IPG). For reference the measurements were repeated in the same pig at 1.5 T and, at both field strengths, in a phantom. Results: At 3.0 T, the maximal temperature elevations at DBS electrodes were 0.46 degrees C and 2.3 degrees C, for the low- and high-SAR sequences, respectively. No heating was observed on the implanted IPG during any of the measurements. Measurements of in vivo heating differed from those obtained in the phantom. Conclusion: The 3.0-T MRI using GRE EPI and IR-prepped GRE sequences resulted in local temperature elevations at DBS electrodes of no more than 0.46 degrees C. Although no extrapolation should be made to human exams and much further study will be needed, these preliminary data are encouraging for the future use 3.0-T MM in patients with DES. (C) 2013 Elsevier Inc. All rights reserved.
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